Patents by Inventor Ching-Fa Yao

Ching-Fa Yao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing indenoisoquinoline derivatives
    Patent number: 10336704
    Abstract: A method for preparing indenoisoquinoline derivatives represented by the following formula (I) is disclosed, which comprises the following steps: (A) providing a first reactant represented by the following formula (II) and a second reactant represented by the following formula (III): and (B) reacting the first reactant represented by the formula (II) and the second reactant represented by the formula (III) in a solvent and selectively adding R2NH2 therein, to obtain the indenoisoquinoline derivatives represented by the formula (I), wherein, R1, R2, R3, A, X, Y, Z, m and n are defined in the specification.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: July 2, 2019
    Assignee: NATIONAL TAIWAN NORMAL UNIVERSITY
    Inventor: Ching-Fa Yao
  • Method for Preparing Indenoisoquinoline Derivatives
    Publication number: 20190127330
    Abstract: A method for preparing indenoisoquinoline derivatives represented by the following formula (I) is disclosed, which comprises the following steps: (A) providing a first reactant represented by the following formula (II) and a second reactant represented by the following formula (III): and (B) reacting the first reactant represented by the formula (II) and the second reactant represented by the formula (III) in a solvent and selectively adding R2NH2 therein, to obtain the indenoisoquinoline derivatives represented by the formula (I), wherein, R1, R2, R3, A, X, Y, Z, m and n are defined in the specification.
    Type: Application
    Filed: December 29, 2017
    Publication date: May 2, 2019
    Inventor: Ching-Fa YAO
  • Method for treating abnormal ?-amyloid mediated diseases
    Patent number: 9795600
    Abstract: A method for treating abnormal ?-amyloid mediated diseases is disclosed, comprising administering a pharmaceutical composition to a subject in need, wherein the pharmaceutical composition comprises an indolylquinoline derivative represented by the following formula 1:
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: October 24, 2017
    Assignee: NATIONAL TAIWAN NORMAL UNIVERSITY
    Inventors: Guey-Jen Lee-Chen, Hsiu-Mei Hsieh, Ching-Fa Yao
  • Method for treating abnormal polyglutamine-mediated disease
    Patent number: 9393229
    Abstract: A method for treating an abnormal polyglutamine-mediated disease is disclosed, wherein indole and an indole-based compound contained in a pharmaceutical composition used in the method of the present invention can reduce the polyglutamine aggregation through decreasing reactive oxygen species production and increasing the activity of chaperone and autophagy.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: July 19, 2016
    Assignee: NATIONAL TAIWAN NORMAL UNIVERSITY
    Inventors: Guey-Jen Lee-Chen, Hsiu-Mei Hsieh, Ching-Fa Yao
  • METHOD FOR TREATING ABNORMAL B-AMYLOID MEDIATED DISEASES
    Publication number: 20160143899
    Abstract: A method for treating abnormal ?-amyloid mediated diseases is disclosed, comprising administering a pharmaceutical composition to a subject in need, wherein the pharmaceutical composition comprises an indolylquinoline derivative represented by the following formula 1:
    Type: Application
    Filed: May 12, 2015
    Publication date: May 26, 2016
    Inventors: Guey-Jen LEE-CHEN, Hsiu-Mei HSIEH, Ching-Fa YAO
  • METHOD FOR TREATING ABNORMAL POLYGLUTAMINE-MEDIATED DISEASE
    Publication number: 20140357689
    Abstract: A method for treating an abnormal polyglutamine-mediated disease is disclosed, wherein indole and an indole-based compound contained in a pharmaceutical composition used in the method of the present invention can reduce the polyglutamine aggregation through decreasing reactive oxygen species production and increasing the activity of chaperone and autophagy.
    Type: Application
    Filed: May 20, 2014
    Publication date: December 4, 2014
    Applicant: National Taiwan Normal University
    Inventors: Guey-Jen LEE-CHEN, Hsiu-Mei HSIEH, Ching-Fa YAO
  • Catalyzed Reaction for Forming Indole-Based Compounds and Their Application in Anticancer Agents
    Publication number: 20080139637
    Abstract: The present invention discloses a method for forming indole-based compounds, wherein the method comprises a reaction of ?,?-unsaturated ketone or aldehyde with indole or its derivative in the presence of at least one kind of Lewis acid. The Lewis acid comprises one of the following groups: metal halides, halogens, inorganic ammonia salts, organic sulfonate and sulfonic acid. Furthermore, this invention discloses 3-indole based compounds applied as anticancer agents.
    Type: Application
    Filed: December 6, 2006
    Publication date: June 12, 2008
    Applicant: NATIONAL TAIWAN NORMAL UNIVERSITY
    Inventors: Ching-Fa Yao, Yi-Ching Wang