Patents by Inventor Ching-Fu Tu

Ching-Fu Tu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRECISE BREEDING METHODS FOR GENE-EDITED NON-HUMAN ANIMALS
    Publication number: 20230292720
    Abstract: The present invention relates to a breeding method for generating gene-edited non-human animals. In particular, the method of the present invention features simultaneous reprograming and gene-editing carried out in somatic cells and subsequent subcloning and genotyping conducted at the in vitro cell stage to obtain precisely gene-edited induced pluripotency stem cells (iPSCs) which are then used in somatic nuclear transfer (SCNT) to generate a precisely gene-edited non-human animal embryo and a resultant gene-edited non-human animal.
    Type: Application
    Filed: March 15, 2023
    Publication date: September 21, 2023
    Applicant: Agricultural Technology Research Institute
    Inventors: Ching-Fu Tu, Chin-Kai Chuang, Shu-Hui Peng, Yu-Hsiu Su
  • Transgenic pigs carrying both hHO-1 and hDAF transgenes for xenotransplantation
    Patent number: 7378569
    Abstract: The invention provides a transgenic animal carrying two transgenes, one encoding a human decay accelerating factor (hDAF) and the other encoding a human heme oxygenase-1 (hHO)-1, which are useful for providing cells, tissues or organs therefrom for xenotransplantation.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: May 27, 2008
    Assignee: Animal Technology Institute Taiwan
    Inventors: Ching-Fu Tu, Chi-Kai Yang, Ming-Shing Liu, Lin-Lin Ho, Kuei-Feng Huang, Chun-Jean Lee, Hao-Chih Tai
  • Expression vector for hirudin and transformed cells and transgenic animals containing said vector
    Publication number: 20070016969
    Abstract: The present invention relates to a nucleic acid construct encoding hirudin and a transgenic mammal whose genome comprises the nucleic acid construct as well as a process for producing hirudin from the transgenic mammal.
    Type: Application
    Filed: December 3, 2003
    Publication date: January 18, 2007
    Inventors: Ching-Fu Tu, Chi-Kai Yang, Chich-Sheng Lin, Chon-Ho Yen, I-Chung Chen, Shinn-Chih Wu, Yu-Ling Sun, Ming-Shing Liu, Ping-Cheng Yang
  • Transgenic pig containing heat shock protein 70 transgene
    Patent number: 7115796
    Abstract: The invention provides a transgenic pig having incorporated into its genome a HSP70 gene or fragment thereof, whereby the transgenic pig overexpresses HSP70. The transgenic pig of the invention can be used in the production of HSP in large quantities, as a xenograft source for transplantation and as an animal model close to human for illustrating the protective roles of HSP. Furthermore, the transgenic pig of the invention has a better meat quality and exhibits an increased growth rate and a reduced backfat thickness.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: October 3, 2006
    Assignee: Animal Technology Institute
    Inventors: Bor-Show Tzang, Ching-Fu Tu, Wen-Chuan Lee, Ming-Yu Chen, San-Yuan Huang, Jyh-Hung Lin
  • Transgenic pigs carrying both hHO-1 and hDAF transgenes for xenotransplantation
    Publication number: 20050268347
    Abstract: The invention provides a transgenic animal carrying two transgenes, one encoding a human decay accelerating factor (hDAF) and the other encoding a human heme oxygenase-1 (hHO)-1, which are useful for providing cells, tissues or organs therefrom for xenotransplantation.
    Type: Application
    Filed: June 1, 2004
    Publication date: December 1, 2005
    Applicant: Animal Technology Institute Taiwan
    Inventors: Ching-Fu Tu, Chi-Kai Yang, Ming-Shing Liu, Lin-Lin Ho, Kuei-Fen Huang, Chun-Jean Lee, Hao-Chih Tai
  • Method for generating non-human mammalian chimeric embryo
    Publication number: 20050138680
    Abstract: The present invention relates to a method for generating non-human mammalian chimeric embryo. The method involves coculturing denuded non-human mammalian embryos with cells in an Eppendorf micro test tube. The chimeric embryo obtained is then transferred into a non-human recipient mammal so as to develop into a non-human chimeric fetus, non-human chimeric mammal, an embryonic stem cell-derived fetus or an embryonic stem cell-derived mammal.
    Type: Application
    Filed: June 25, 2004
    Publication date: June 23, 2005
    Applicant: ANIMAL TECHNOLOGY INSTITUTE TAIWAN
    Inventors: Kun-Hsiung Lee, Hut-Wen Wang, Hui-Rong Chang, Ching-Fu Tu, Chih-Jen Lin
  • Transgenic pig containing heat shock protein 70 transgene
    Publication number: 20030208786
    Abstract: The invention provides a transgenic pig having incorporated into its genome a HSP70 gene or fragment thereof, whereby said transgenic pig overexpresses HSP70. The transgenic pig of the invention can be used in the production of HSP in large quantities, as a xenograft source for transplation and as an animal model close to human for illustrating the protective roles of HSP. Furthermore, the transgenic pig of the invention has a better meat quality and exhibits an increased growth rate and a reduced backfat thickness.
    Type: Application
    Filed: January 24, 2003
    Publication date: November 6, 2003
    Inventors: Bor-Show Tzang, Ching-Fu Tu, Wen-Chuan Lee, Ming-Yu Chen, San-Yuan Huang, Jyh-Hung Lin
  • Transgenic pig containing heat shock protein 70 transgene
    Publication number: 20030208785
    Abstract: The invention provides a transgenic pig having incorporated into its genome a HSP70 gene or the fragment thereof, whereby said transgenic pig overexpresses HSP70. The transgenic pig of the invention can be used in the production of HSP in large quantity and used as a xenograft source for transplation and an animal model close to human for illustrating the protective roles of HSP. Furthermore, the transgenic pig of the invention has a better meat quality and exhibits an increased growth rate and a reduced backfat thickness.
    Type: Application
    Filed: May 6, 2002
    Publication date: November 6, 2003
    Applicant: Animal Technology Institute Taiwan
    Inventors: Bor-Show Tzang, Ching-Fu Tu, Wen-Chuan Lee, Ming-Yu Chen, San-Yuan Huang, Jyh-Hung Lin
  • Transgenic swine having HLA-D gene, swine cells thereof and xenografts therefrom
    Patent number: 6639122
    Abstract: The invention provides a transgenic swine having a transgene encoding a human HLA-DQ or HLA-DR protein, and the swine cells thereof. The invention also provides a graft derived from the transgenic swine, in particular a graft-organ or a graft-tissue, which is useful for grafting into a human recipient.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: October 28, 2003
    Assignee: Animal Technology Institute Taiwan
    Inventors: Ching-Fu Tu, Chun-Jean Lee, Jang-Ming Lee, Kimiyoshi Tsuji