Abstract: A method of managing cancer in a patient’s cerebrospinal fluid (“CSF”) forms a fluid circuit by fluidly communicating a set of catheters (“a catheter”) with the patient’s brain ventricle and the patient’s lumbar and, while controlling the flow rate of the CSF through the CSF fluid circuit, filters cancer cells from the CSF through the fluid circuit. The method also determines both a variable indicative of cancer cell concentration in the CSF, and at some point, that the variable has attained or passed through a threshold value (e.g., greater than a maximum threshold value or below a minimum threshold value). The method stops controlling the CSF flow rate in response to the variable attaining and/or passing through the threshold value. The CSF flow rate therefore preferably returns to a natural CSF flow rate of the patient after stopping control of the CSF flow rate. A system preferably performs these acts.

Abstract: Cerebrospinal fluid (CSF) and other fluid amelioration systems completely or partially implantable within a mammalian subject and associated methods include a substrate and an agent for amelioration of a toxic biomolecule present in the CSF or fluid, wherein the agent is disposed on or within the substrate.

Abstract: Cerebrospinal fluid (CSF) and other fluid amelioration systems completely or partially implantable within a mammalian subject and associated methods include a substrate and an agent for amelioration of a toxic biomolecule present in the CSF or fluid, wherein the agent is disposed on or within the substrate.

Abstract: Cerebrospinal fluid (CSF) and other fluid amelioration systems completely or partially implantable within a mammalian subject and associated methods include a substrate and an agent for amelioration of a toxic biomolecule present in the CSF or fluid, wherein the agent is disposed on or within the substrate.

Abstract: A fishing line winder is disclosed. The line winder is combined with a line reel, so that a fishing line is sequentially reeled and unreeled. The line winder is a machine for preventing reverse winding and tangling, where a base of the fishing line winder is provided with a shaft, and a driving member drives the shaft to rotate, while a spindle is provided with a line spool, an abutment wheel and an unidirectional bearing; a resistance against the rotation of the abutment wheel is formed by means of a brake pad, thus preventing reverse winding and tangling when the fishing line is reeled onto and unreeled from the line reel.

Abstract: Methods and apparatus for analyzing the material properties and behavior of cement as it hydrates under simulated downhole conditions. A wellbore cement simulator includes a temperature and pressure controlled innermost oil-filled container; an annulus in contact with the innermost container configured to hold a cement sample; a mesh sleeve in contact with the annulus wherein the mesh sleeve is water permeable to permit hydration of the cement sample; a steel sleeve in contact with the mesh sleeve; an elastomeric bladder surrounding the steel sleeve; and a temperature and pressure controlled outermost oil-filled container.

Abstract: Methods and apparatus for analyzing the material properties and behavior of cement as it hydrates under simulated downhole conditions are disclosed. A wellbore cement simulator includes a temperature and pressure controlled innermost oil-filled container; an annulus in contact with the innermost container configured to hold a cement sample; a mesh sleeve in contact with the annulus wherein the mesh sleeve is water permeable to permit hydration of the cement sample; a steel sleeve in contact with the mesh sleeve; an elastomeric bladder surrounding the steel sleeve; and a temperature and pressure controlled outermost oil-filled container.

Abstract: A fishing line winder is disclosed. The line winder is combined with a line reel, so that a fishing line is sequentially reeled and unreeled. The line winder is a machine for preventing reverse winding and tangling, where a base of the fishing line winder is provided with a shaft, and a driving member drives the shaft to rotate, while a spindle is provided with a line spool, an abutment wheel and an unidirectional bearing; a resistance against the rotation of the abutment wheel is formed by means of a brake pad, thus preventing reverse winding and tangling when the fishing line is reeled onto and unreeled from the line reel.

Abstract: Provided herein are materials with angle-dependent solar radiation absorptivity, reflectivity, or emissivity. In some embodiments, the material exhibits angle-dependent reflectivity and angle-dependent emissivity. The material can appear as one color or a uniform color to an observer. In some embodiments, the material appears to have different colors from different angles of viewing.

Abstract: Quantum simulation methods are used to encode the quantum response of a molecular system so as to improve the sensitivity for detection of a target material, while rejecting background. The perturbation and response information may be used to discover the system function of a quantum system, or more generally, of a complex system, such as a physiological system. The approach may be applied to medical non-invasive, real-time, continuous molecular detection and quantification techniques through coherent Raman spectroscopy to enable a significantly more attractive course of therapy than existing protocols.

Abstract: System and methods are provided to perform non-invasive, real-time, continuous molecular detection and quantification of molecular species in a sample or animal subject using Raman spectroscopy. Such systems and methods may be applied to identify and quantify molecular species found in the body, which may be useful for prenatal diagnosis, detecting deep skin infections, performing cerebral spinal fluid assessment, measuring arterial blood gases, blood glucose, cardiac biomarkers, creatinine flow rates. The non-invasive, quantification of such molecular species continuously in real time enables a significantly more attractive course of therapy than existing protocols.

Abstract: An eye injector for transferring a substance across the surface of the eye of an animal includes a needle-free injector and a patient positioning mechanism. The needle-free injector includes a reservoir for storing the substance to be transferred, a nozzle in fluid communication with the reservoir; and a controllable electromagnetic actuator in communication with the reservoir. The eye injector can also include a targeting light source for directing a beam of light into a pupil of the eye. The needle-free injector can be positioned adjacent to the lens of the eye, therefore producing a jet that intersects with the beam of light at a point in the retina.