Patents by Inventor Ching-Jun Lai

Ching-Jun Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C-terminally truncated dengue and Japanese encephalitis virus envelope proteins
    Patent number: 5494671
    Abstract: The present invention relates to C-terminally truncated flavivirus envelope proteins 80-81% in size which are more immunogenic than their counterpart full-length proteins. The present invention further relates to recombinant viruses which encode the truncated protein and to host cells infected therewith. Host cells express the truncated protein on their outer membrane and secrete it into the medium. The present invention further relates to vaccines for use against flavivirus infection. The vaccines include either a recombinant vaccinia virus expressing the truncated envelope protein of the present invention, and the truncated envelope protein produced by a recombinant baculovinis.
    Type: Grant
    Filed: August 20, 1991
    Date of Patent: February 27, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Ching-Jun Lai, Ruhe Men, Lei-Ron Jan, Michael Bray