Abstract: This application relates to modified influenza B hemagglutinin polypeptides and nucleic acids, such as messenger ribonucleic acids (mRNAs), encoding the same, as well as compositions comprising the same, vaccines comprising the same, and methods of using the same, such as in the prevention and/or treatment of diseases or conditions caused by influenza B viruses.

Abstract: Provided herein are antibodies or antigen binding fragments thereof having a binding specificity for p95HER2 or for CD73, bispecific antibodies comprising a first antigen binding region that binds to p95HER2 or CD73 and a second antigen binding region that binds to an immune checkpoint molecule or an immune stimulatory molecule, and antibody-drug conjugates thereof. Also provided herein are pharmaceutical compositions comprising the antibodies, antigen binding fragments thereof, bispecific antibodies or antibody drug conjugates thereof, and methods of use thereof. The methods of use include method of treating cancer.

Abstract: Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.

Abstract: Provided herein are antibodies and antibody fragments that bind to SARS-COV-2 spike protein. Methods of using these antibodies in in vitro methods are provided. Methods of using these antibodies in vivo to treat or prevent SARS-COV-2 infections are also provided.

Abstract: Provided herein are chimeric hMPV/RSV F proteins. In some aspects, the chimeric hMPV/RSV F proteins exhibit enhanced conformational stability, enhanced thermostability, and/or increased expression. Methods are also provided for use of the chimeric F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.

Abstract: Provided herein are antibodies and antibody fragments that bind to the S2 domains of SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins. Methods of using these antibodies in in vitro methods are provided. Methods of using these antibodies in vivo to treat or prevent SARS-CoV-2 infections are also provided.

Abstract: Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.

Abstract: Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.

Abstract: Hybrid positioning methods and electronic apparatuses are provided. A representative method includes: obtaining initial location information; computing initial moving information based upon the sensor readings; computing estimated location information based on the initial moving information and the initial location information; acquiring geographical location readings if a location update condition is satisfied; generating reference location information based on the geographical location readings acquired; comparing the estimated location information with the reference location information to obtain a deviation information; computing a calibrated moving information based on the estimated location information and the deviation information; and computing a calibrated location information based on the deviation information, calibrated moving information and the estimated location information.

Abstract: Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.

Abstract: Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.

Abstract: Provided herein are engineered protein comprising stabilized coronavirus S protein ectodomains, such as stabilized SARS-CoV-2 S protein ectodomains. In some aspects, the engineered S protein ectodomains exhibit enhanced antigenicity. Methods are also provided for use of the engineered S protein ectodomains as diagnostics, in screening platforms, and/or in vaccine compositions.

Abstract: Provided herein are engineered Coronavirus S proteins, such as engineered SARS-CoV-2 S proteins. In some aspects, the engineered S proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of engineered proteins as diagnostics, in screening platforms and/or in vaccine compositions.

Abstract: Systems and methods for facilitating exercise monitoring are provided. A representative method includes: using a processor, having processor circuitry, to: compute an orientation change of the single wearable device based on the motion readings; determine a current training type and a target status associated with the current training type based on the schedule of training types; select one of the computing models associated with the current training type; compare the set of matching orientation changes corresponding to the current training type and the orientation change of the single wearable device with respect to a determination threshold corresponding to the current training type until the target status associated with the current training type has been attained; and compute an exercise amount associated with the current training type based on the target status attained.

Abstract: Electronic devices and methods for providing location information are provided, of which a representative method includes: generating sensor readings corresponding to sensed motion of the electronic device; determining a reference location information; computing a GPS-fused location information based on the reference location information and the sensor readings; generating a GPS-required event based on a change of the GPS-fused location information; generating a GPS-not-required event responsive to the reference location information being determined; receiving the GPS-fused location information and one of either the GPS-required event or the GPS-not-required event; responsive to the GPS-required event being received, operating the GPS receiver in a location information-acquiring mode during which the GPS receiver generates geographical location readings; and responsive to the GPS-not-required event being received, operating the GPS receiver in a power-saving mode during which the GPS receiver is deactivated.

Abstract: Hybrid positioning methods and electronic apparatuses are provided. A representative method includes: obtaining initial location information; computing initial moving information based upon the sensor readings; computing estimated location information based on the initial moving information and the initial location information; acquiring geographical location readings if a location update condition is satisfied; generating reference location information based on the geographical location readings acquired; comparing the estimated location information with the reference location information to obtain a deviation information; computing a calibrated moving information based on the estimated location information and the deviation information; and computing a calibrated location information based on the deviation information, calibrated moving information and the estimated location information.

Abstract: Hybrid positioning methods and electronic apparatuses are provided. A representative method includes: obtaining initial location information; computing initial moving information based upon the sensor readings; computing estimated location information based on the initial moving information and the initial location information; acquiring geographical location readings if a location update condition is satisfied; generating reference location information based on the geographical location readings acquired; comparing the estimated location information with the reference location information to obtain a deviation information; computing a calibrated moving information based on the estimated location information and the deviation information; and computing a calibrated location information based on the deviation information, calibrated moving information and the estimated location information.

Abstract: Systems and methods for facilitating exercise monitoring are provided. A representative method includes: using a processor, having processor circuitry, to: compute an orientation change of the single wearable device based on the motion readings; determine a current training type and a target status associated with the current training type based on the schedule of training types; select one of the computing models associated with the current training type; compare the set of matching orientation changes corresponding to the current training type and the orientation change of the single wearable device with respect to a determination threshold corresponding to the current training type until the target status associated with the current training type has been attained; and compute an exercise amount associated with the current training type based on the target status attained.

Abstract: Systems and methods for facilitating exercise monitoring are provided.

Abstract: Systems and methods for facilitating exercise monitoring are provided.