Abstract: A light source device includes a light guide plate, an optical adhesive, and a light source element. The light guide plate includes a light guide substrate and an enhancement layer. The light guide substrate has a light incident surface, a first surface, and a second surface. The first surface is opposite to the second surface, and the light incident surface extends between the first surface and the second surface. The enhancement layer is disposed on the light guide substrate. A thickness of the enhancement layer is from 1 micrometer to 25 micrometers and a first refractive index of the light guide substrate is greater than a second refractive index of the enhancement layer. The optical adhesive is interposed between the first surface of the light guide substrate and the optical adhesive. The light source element is disposed beside the light incident surface to emit light toward the light incident surface.

Abstract: Disclosed are methods and compositions for inducing proliferation in cardiomyocyte cells or for high-throughput assays.

Abstract: Disclosed are methods of detecting myocardial enhancer RNA levels in mammalian cardiomyocytes. In a further embodiment, a method of disrupting assembly of an enhancer DNA-Myh6 promoter-Myh7 promoter complex, is provided wherein the method comprises providing enhancer RNA to a cardiomyocyte.

Abstract: Methods are disclosed herein for administering a FoxM1 inhibitor for preventing, treating, and/or reducing cardiac hypertrophy and/or cardiac failure. Particularly, the methods are directed to the use of a FoxM1 inhibitor to block the function of FoxM1-Brg1 complex, thereby reversing the ACE/ACE2 expression ratio such to protect the heart from hypertrophy and failure.

Abstract: A vehicle tutorial system includes a data storage device having at least one vehicle tutorial, an on-board identification sensor, an on-board vehicle communication device, a tutorial manager device located in a cloud computer and/or the remote device, and an on-board vehicle controller. The on-board vehicle controller is programmed to identify the user of the vehicle based on information from the on-board identification sensor, select the vehicle tutorial, select the remote device associated with the user of the vehicle, offer the vehicle tutorial to the user at a first time, and upon the user declining the offer at the first time, send the vehicle tutorial to the tutorial manager device. The tutorial manager device includes a processor programmed to offer the vehicle tutorial to the user at a time later than the first time on the on-board vehicle display or on the remote device.

Abstract: A vehicle tutorial system includes a data storage device having at least one vehicle tutorial, an on-board identification sensor, an on-board vehicle communication device, a tutorial manager device located in a cloud computer and/or the remote device, and an on-board vehicle controller. The on-board vehicle controller is programmed to identify the user of the vehicle based on information from the on-board identification sensor, select the vehicle tutorial, select the remote device associated with the user of the vehicle, offer the vehicle tutorial to the user at a first time, and upon the user declining the offer at the first time, send the vehicle tutorial to the tutorial manager device. The tutorial manager device includes a processor programmed to offer the vehicle tutorial to the user at a time later than the first time on the on-board vehicle display or on the remote device.

Abstract: Nucleic acids encoding modified myosin heavy-chain-associated RNA transcripts are provided. The modified myosin heavy-chain-associated RNA transcripts belongs to a cluster of long noncoding RNAs (lncRNA) and bind to chromatin remodeler Brg1 to inhibit Brg1's genomic targeting and gene regulation function. The modified myosin heavy-chain-associated RNA transcripts expressed in an individual inhibit Brg1's gene regulation function and protect the heart of the individual from myopathy and failure. One of the modified heavy-chain-associated RNAs is a 400 base pair fragment segmented from a natural 779 base pair sequence of Mhrt (Mhrt779) and has the same cardioprotective effects as the Mhrt779.

Abstract: Methods are disclosed herein for administering a FoxM1 inhibitor for preventing, treating, and/or reducing cardiac hypertrophy and/or cardiac failure. Particularly, the methods are directed to the use of a FoxM1 inhibitor to block the function of FoxM1-Brg1 complex, thereby reversing the ACE/ACE2 expression ratio such to protect the heart from hypertrophy and failure.

Abstract: Nucleic acids encoding modified myosin heavy-chain-associated RNA transcripts are provided. The modified myosin heavy-chain-associated RNA transcripts belongs to a cluster of long noncoding RNAs (lncRNA) and bind to chromatin remodeler Brg1 to inhibit Brg1's genomic targeting and gene regulation function. The modified myosin heavy-chain-associated RNA transcripts expressed in an individual inhibit Brg1's gene regulation function and protect the heart of the individual from myopathy and failure. One of the modified heavy-chain-associated RNAs is a 400 base pair fragment segmented from a natural 779 base pair sequence of Mhrt (Mhrt779) and has the same cardioprotective effects as the Mhrt779.

Abstract: A vehicle window assembly includes a vehicle structure, a window panel and a light source. The vehicle structure defines a viewing aperture. The window panel is mounted to the vehicle structure and covers the viewing aperture. The window panel has a peripheral edge surrounding a first window surface and a second window surface opposite the first window surface. The first window surface includes an etched section. The light source is mounted to the vehicle structure adjacent to a portion of the peripheral edge of the window panel such that light from the light source is directed to the portion of the peripheral edge of the window panel. The light travels in a lateral direction through the window panel selectively illuminating the etched section.

Abstract: Methods and compositions are provided for the diagnosis and treatment of heart diseases relating to cardiac hypertrophy, and for the regulation of proliferation and differentiation of cardiomyocyte progenitors in vitro. The detection of expression of components of the BAF complex, including, without limitation, detection of expression of Brg1, provides useful methods for early detection, diagnosis, staging, and monitoring of conditions leading to hypertrophy and enlargement of the heart. Manipulation of Brg1 activity provides for therapeutic intervention in the development of cardiac hypertrophy, where methods of decreasing Brg1 activity, e.g. through inhibition of binding, decreasing expression, and the like, reduces cardiac hypertrophy.

Abstract: A vehicle window assembly includes a vehicle structure, a window panel and a proximity switch. The vehicle structure defines a passenger compartment of a vehicle and a viewing aperture. The window panel is mounted to the vehicle structure and covers the viewing aperture such that a first surface of the window panel faces the passenger compartment of the vehicle structure. The proximity switch overlays a portion of the first surface of the window panel.

Abstract: A vehicle window assembly includes a vehicle structure, a window panel and a proximity switch. The vehicle structure defines a passenger compartment of a vehicle and a viewing aperture. The window panel is mounted to the vehicle structure and covers the viewing aperture such that a first surface of the window panel faces the passenger compartment of the vehicle structure. The proximity switch overlays a portion of the first surface of the window panel.

Abstract: A vehicle window assembly includes a vehicle structure, a window panel and a light source. The vehicle structure defines a viewing aperture. The window panel is mounted to the vehicle structure and covers the viewing aperture. The window panel has a peripheral edge surrounding a first window surface and a second window surface opposite the first window surface. The first window surface includes an etched section. The light source is mounted to the vehicle structure adjacent to a portion of the peripheral edge of the window panel such that light from the light source is directed to the portion of the peripheral edge of the window panel. The light travels in a lateral direction through the window panel selectively illuminating the etched section.

Abstract: The present invention discloses a method of applying micro-protection in defect analysis. The method includes providing a substrate having at least one defect thereon, forming the micro-protection on the surface of the defect, confirming the site of the defect, and forming a specimen of the defect by utilizing a focused ion beam microscope.

Abstract: The present invention discloses a method of applying micro-protection in defect analysis. The method includes providing a substrate having at least one defect thereon, forming the micro-protection on the surface of the defect, confirming the site of the defect, and forming a specimen of the defect by utilizing a focused ion beam microscope.