Patents by Inventor Ching SHANG
Ching SHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11981711Abstract: Provided herein are compositions, systems, kits, and methods for treating nervous system injuries caused by trauma or neurodegeneration or aging in a subject by administering a CSPG or SOCS3 reduction peptide (CRP and SRP respectively), or a nucleic acid sequence encoding the CRP or SRP, wherein both the CRP and SRP comprise a cell membrane penetrating domain, and a lysosome targeting domain, and the CRP further comprises a chondroitin sulfate proteoglycan (CSPG) binding domain, and the SRP further comprises a suppressor of cytokine signaling-3 (SOCS3) binding domain.Type: GrantFiled: December 30, 2020Date of Patent: May 14, 2024Assignee: The Cleveland Clinic FoundationInventors: Yu-Shang Lee, Ching-Yi Lin
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Patent number: 11961891Abstract: A semiconductor device includes a channel component of a transistor and a gate component disposed over the channel component. The gate component includes: a dielectric layer, a first work function metal layer disposed over the dielectric layer, a fill-metal layer disposed over the first work function metal layer, and a second work function metal layer disposed over the fill-metal layer.Type: GrantFiled: March 21, 2022Date of Patent: April 16, 2024Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING CO., LTDInventors: Ru-Shang Hsiao, Ching-Hwanq Su, Pohan Kung, Ying Hsin Lu, I-Shan Huang
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Patent number: 11949000Abstract: A method includes forming a dummy gate stack over a fin protruding from a semiconductor substrate, forming gate spacers on sidewalls of the dummy gate stack, forming source/features over portions of the fin, forming a gate trench between the gate spacers, which includes trimming top portions of the gate spacers to form a funnel-like opening in the gate trench, and forming a metal gate structure in the gate trench. A semiconductor structure includes a fin protruding from a substrate, a metal gate structure disposed over the fin, gate spacers disposed on sidewalls of the metal gate structure, where a top surface of each gate spacer is angled toward the semiconductor fin, a dielectric layer disposed over the top surface of each gate spacer, and a conductive feature disposed between the gate spacers to contact the metal gate structure, where sidewalls of the conductive feature contact the dielectric layer.Type: GrantFiled: July 27, 2022Date of Patent: April 2, 2024Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING CO., LTD.Inventors: Ru-Shang Hsiao, Ching-Hwanq Su, Pin Chia Su, Ying Hsin Lu, I-Shan Huang
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Patent number: 10149783Abstract: This invention provides an oral apparatus and method capable of alleviating or curing snore and obstructive sleep apnea by applying a negative pressure through a mini oral interface to the oral cavity. The mini oral interface creates a secure connection between the interface and mouth or teeth and prevents the interface from falling off. The oral interface also provides fixation between upper and lower lips (or tooth) and prevents opening of patient's mouth during sleeping. The negative pressure pulls the tongue toward upper palate and also pulls the soft palate forward as well. By moving the tongue and the soft palate in a forward direction, the patentcy of the upper airway near the pharynx is maintained to prevent sleep-disordered breathing. The negative pressure will pull the lips inward to close the mouth ad prevent air from entering the oral cavity from atmosphere.Type: GrantFiled: February 22, 2016Date of Patent: December 11, 2018Assignee: Somnics, Inc.Inventors: Chung-Chu Chen, Ching Shang, Marina Sirota, Zhen Yao
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Patent number: 9387117Abstract: This invention provides an oral apparatus and method capable of alleviating or curing snore and obstructive sleep apnea by applying a negative pressure through a mini oral interface to the oral cavity. The mini oral interface creates a secure connection between the interface and mouth or teeth and prevents the interface from falling off. The oral interface also provides fixation between upper and lower lips (or tooth) and prevents opening of patient's mouth during sleeping. The negative pressure pulls the tongue toward upper palate and also pulls the soft palate forward as well. By moving the tongue and the soft palate in a forward direction, the patency of the upper airway near the pharynx is maintained to prevent sleep-disordered breathing. The negative pressure will pull the lips inward to close the mouth ad prevent air from entering the oral cavity from atmosphere.Type: GrantFiled: September 27, 2010Date of Patent: July 12, 2016Assignee: Somnics, Inc.Inventors: Chung-Chu Chen, Ching Shang, Marina Sirota, Zhen Yao
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Publication number: 20160166425Abstract: This invention provides an oral apparatus and method capable of alleviating or curing snore and obstructive sleep apnea by applying a negative pressure through a mini oral interface to the oral cavity. The mini oral interface creates a secure connection between the interface and mouth or teeth and prevents the interface from falling off. The oral interface also provides fixation between upper and lower lips (or tooth) and prevents opening of patient's mouth during sleeping. The negative pressure pulls the tongue toward upper palate and also pulls the soft palate forward as well. By moving the tongue and the soft palate in a forward direction, the patentcy of the upper airway near the pharynx is maintained to prevent sleep-disordered breathing. The negative pressure will pull the lips inward to close the mouth ad prevent air from entering the oral cavity from atmosphere.Type: ApplicationFiled: February 22, 2016Publication date: June 16, 2016Inventors: Chung-Chu Chen, Ching Shang, Marina Sirota, Zhen Yao
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Patent number: 8040102Abstract: A solar-powered LED street light that can immediately report its power data. The disclosed LED street light has a solar cell, a switch power supply unit, and a power cable data communicating unit. The mains power cable of the LED street light connects to the switch power supply unit for providing it with DC power. The solar cell has a solar board, a battery and a charge controller. The charge controller can also provide the LED street light with DC power. The charge controller has a power data digital output interface for connecting with the power cable data communicating unit, outputting the power data of the solar cell to the power cable data communicating unit. Through the mains power cable, the status of solar cell of each LED lamp is monitored.Type: GrantFiled: January 27, 2009Date of Patent: October 18, 2011Assignee: Acbel Polytech Inc.Inventors: Ching-Shang Kao, Wei-Liang Lin
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Publication number: 20110073119Abstract: This invention provides an oral apparatus and method capable of alleviating or curing snore and obstructive sleep apnea by applying a negative pressure through a mini oral interface to the oral cavity. The mini oral interface creates a secure connection between the interface and mouth or teeth and prevents the interface from falling off. The oral interface also provides fixation between upper and lower lips (or tooth) and prevents opening of patient's mouth during sleeping. The negative pressure pulls the tongue toward upper palate and also pulls the soft palate forward as well. By moving the tongue and the soft palate in a forward direction, the patentcy of the upper airway near the pharynx is maintained to prevent sleep-disordered breathing. The negative pressure will pull the lips inward to close the mouth ad prevent air from entering the oral cavity from atmosphere.Type: ApplicationFiled: September 27, 2010Publication date: March 31, 2011Applicant: SOMNICS, INC.Inventors: Chung-Chu CHEN, Ching SHANG, Marina SIROTA, Zhen YAO
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Patent number: 7825274Abstract: A bisbiphenylacylphosphine oxide of formula (I) and its preparation method are provided. The formula of —Ar— is First, 10-chloro-9,10-dihydro-9-oxa-10-phosphaphenanthrene (CDOP) is prepared by using 2-phenylphenol, and then is esterified to synthesize 6-methoxy-(6H)-dibenz[c,e][1,2]oxa-phosphorin (MDOP). Next, acid chloride compounds are added for performing the Arbuzov reaction to synthesize bisbiphenylacylphosphine oxide. CDOP is hydrolyzed to be derived into 9,10-dihydro-9-oxa-10-phosphaphen-anthrene-10-oxide (DOPO), and then DOPO reacts with arylaldehyde to form secondary alcohol. Therefore, bisbiphenylacylphosphine oxide is prepared by using secondary alcohol under oxidation. Also, under a coupling reaction, DOPO reacts with the acid chloride compounds by using a Lewis acid as a catalyst to prepare bisbiphenylacylphosphine oxide.Type: GrantFiled: June 18, 2008Date of Patent: November 2, 2010Assignee: Chung Shan Institute of Science and TechnologyInventors: Wen-Chiung Su, Chang-Chih Lin, Ching-Shang Sheng
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Patent number: 7741505Abstract: A bisbiphenylacylphosphine oxide of formula (I) and its preparation method are provided. The formula of —Ar— is First, 10-chloro-9,10-dihydro-9-oxa-10-phosphaphenanthrene (CDOP) is prepared by using 2-phenylphenol, and then is esterified to synthesize 6-methoxy-(6H)-dibenz[c,e][1,2]oxa-phosphorin (MDOP). Next, acid chloride compounds are added for performing the Arbuzov reaction to synthesize bisbiphenylacylphosphine oxide. CDOP is hydrolyzed to be derived into 9,10-dihydro-9-oxa-10-phosphaphen-anthrene-10-oxide (DOPO), and then DOPO reacts with arylaldehyde to form secondary alcohol. Therefore, bisbiphenylacylphosphine oxide is prepared by using secondary alcohol under oxidation. Also, under a coupling reaction, DOPO reacts with the acid chloride compounds by using a Lewis acid as a catalyst to prepare bisbiphenylacylphosphine oxide.Type: GrantFiled: June 18, 2008Date of Patent: June 22, 2010Assignee: Chung Shan Institute of Science and TechnologyInventors: Wen-Chiung Su, Chang-Chih Lin, Ching-Shang Sheng
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Publication number: 20090303703Abstract: A solar-powered LED street light that can immediately report its power data. The disclosed LED street light has a solar cell, a switch power supply unit, and a power cable data communicating unit. The mains power cable of the LED street light connects to the switch power supply unit for providing it with DC power. The solar cell has a solar board, a battery and a charge controller. The charge controller can also provide the LED street light with DC power. The charge controller has a power data digital output interface for connecting with the power cable data communicating unit, outputting the power data of the solar cell to the power cable data communicating unit. Through the mains power cable, the status of solar cell of each LED lamp is monitored.Type: ApplicationFiled: January 27, 2009Publication date: December 10, 2009Inventors: Ching-Shang Kao, Wei-Liang Lin
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Patent number: 7465819Abstract: A bisbiphenylacylphosphine oxide of formula (I) and its preparation method are provided. The formula of —Ar— is First, 10-chloro-9,10-dihydro-9-oxa-10-phosphaphenanthrene (CDOP) is prepared by using 2-phenylphenol, and then is esterified to synthesize 6-methoxy-(6H)-dibenz[c,e][1,2]oxa-phosphorin (MDOP). Next, acid chloride compounds are added for performing the Arbuzov reaction to synthesize bisbiphenylacylphosphine oxide. CDOP is hydrolyzed to be derived into 9,10-dihydro-9-oxa-10-phosphaphen-anthrene-10-oxide (DOPO), and then DOPO reacts with arylaldehyde to form secondary alcohol. Therefore, bisbiphenylacylphosphine oxide is prepared by using secondary alcohol under oxidation. Also, under a coupling reaction, DOPO reacts with the acid chloride compounds by using a Lewis acid as a catalyst to prepare bisbiphenylacylphosphine oxide.Type: GrantFiled: January 24, 2006Date of Patent: December 16, 2008Assignee: Chung Shan Institute of Science and TechnologyInventors: Wen-Chiung Su, Chang-Chih Lin, Ching-Shang Sheng
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Publication number: 20080287701Abstract: A bisbiphenylacylphosphine oxide of formula (I) and its preparation method are provided. The formula of —Ar— is First, 10-chloro-9,10-dihydro-9-oxa-10-phosphaphenanthrene (CDOP) is prepared by using 2-phenylphenol, and then is esterified to synthesize 6-methoxy-(6H)-dibenz[c,e][1,2]oxa-phosphorin (MDOP). Next, acid chloride compounds are added for performing the Arbuzov reaction to synthesize bisbiphenylacylphosphine oxide. CDOP is hydrolyzed to be derived into 9,10-dihydro-9-oxa-10-phosphaphen-anthrene-10-oxide (DOPO), and then DOPO reacts with arylaldehyde to form secondary alcohol. Therefore, bisbiphenylacylphosphine oxide is prepared by using secondary alcohol under oxidation. Also, under a coupling reaction, DOPO reacts with the acid chloride compounds by using a Lewis acid as a catalyst to prepare bisbiphenylacylphosphine oxide.Type: ApplicationFiled: June 18, 2008Publication date: November 20, 2008Applicant: CHUNG SHAN INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Wen-Chiung Su, Chang-Chih Lin, Ching-Shang Sheng
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Publication number: 20080255381Abstract: A bisbiphenylacylphosphine oxide of formula (I) and its preparation method are provided. The formula of —Ar— is First, 10-chloro-9,10-dihydro-9-oxa-10-phosphaphenanthrene (CDOP) is prepared by using 2-phenylphenol, and then is esterified to synthesize 6-methoxy-(6H)-dibenz[c,e][1,2]oxa-phosphorin (MDOP). Next, acid chloride compounds are added for performing the Arbuzov reaction to synthesize bisbiphenylacylphosphine oxide. CDOP is hydrolyzed to be derived into 9,10-dihydro-9-oxa-10-phosphaphen-anthrene-10-oxide (DOPO), and then DOPO reacts with arylaldehyde to form secondary alcohol. Therefore, bisbiphenylacylphosphine oxide is prepared by using secondary alcohol under oxidation. Also, under a coupling reaction, DOPO reacts with the acid chloride compounds by using a Lewis acid as a catalyst to prepare bisbiphenylacylphosphine oxide.Type: ApplicationFiled: June 18, 2008Publication date: October 16, 2008Applicant: CHUNG SHAN INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Wen-Chiung Su, Chang-Chih Lin, Ching-Shang Sheng
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Publication number: 20070173659Abstract: A bisbiphenylacylphosphine oxide of formula (I) and its preparation method are provided. The formula of —Ar— is First, 10-chloro-9,10-dihydro-9-oxa-10-phosphaphenanthrene (CDOP) is prepared by using 2-phenylphenol, and then is esterified to synthesize 6-methoxy-(6H)-dibenz[c,e][1,2]oxa-phosphorin (MDOP). Next, acid chloride compounds are added for performing the Arbuzov reaction to synthesize bisbiphenylacylphosphine oxide. CDOP is hydrolyzed to be derived into 9,10-dihydro-9-oxa-10-phosphaphen-anthrene-10-oxide (DOPO), and then DOPO reacts with arylaldehyde to form secondary alcohol. Therefore, bisbiphenylacylphosphine oxide is prepared by using secondary alcohol under oxidation. Also, under a coupling reaction, DOPO reacts with the acid chloride compounds by using a Lewis acid as a catalyst to prepare bisbiphenylacylphosphine oxide.Type: ApplicationFiled: January 24, 2006Publication date: July 26, 2007Inventors: Wen-Chiung Su, Chang-Chih Lin, Ching-Shang Sheng
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Patent number: D731419Type: GrantFiled: December 18, 2013Date of Patent: June 9, 2015Assignee: ACBEL POLYTECH INC.Inventors: Ching-Shang Kao, Chiu-Lih Chang, Sheng-Yung Lai, Wei-Qiang Li