Patents by Inventor Ching-Shih Chen
Ching-Shih Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110054002Abstract: Compounds and methods for treating cancer or inducing apoptosis in proliferating cells. The compounds are shown in formula I: wherein X is selected from hydroxyl, thiol, and amino; Y is selected from carboxyl and sulfonyl; R1, R2, R3, and R4 are selected from hydrogen, lower alkyl, and combinations thereof; R5, R6, and R7 are selected from hydrogen, halo, nitro, amino, methoxy, and combinations thereof; and pharmaceutically acceptable salts thereof.Type: ApplicationFiled: August 25, 2009Publication date: March 3, 2011Applicant: The Ohio State University Research FoundationInventors: Ching-Shih Chen, Jing-Ru Weng
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Publication number: 20110015242Abstract: Use of a new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I for inducing apoptosis in unwanted rapidly proliferating cells, for treating, inhibiting, or delaying the onset of cancer, and for preventing restenosis in a subject that has undergone an angioplasty or stent: wherein X is selected from the group consisting of alkyl and haloalkyl; Ar is an aryl radical selected from the group consisting of phenyl, biphenyl, naphthyl, anthryl, phenanthryl, and fluorenyl; and wherein Ar is optionally substituted with one or more radicals selected from the group consisting of halo, C1-C4 alkyl, C1-C4 haloalkyl, azido, C1-C4 azidoalkyl, aryl, akylaryl, haloaryl, haloalkylaryl, and combinations thereof; and R is selected from the group consisting of nitrile, acetonitrile, ethylnitrile, propylnitrile, carboxamide, amidine, tetrazole, oxime, hydrazone, acetamidine, aminoacetamide, guanidine, and urea.Type: ApplicationFiled: September 23, 2010Publication date: January 20, 2011Applicant: The Ohio State University Research FoundationInventor: Ching-Shih Chen
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Publication number: 20100273871Abstract: Compounds of formula I: wherein X is selected from oxygen, nitrogen and sulfur; n is 0 or 1; R1 is selected from alkyl, carboxylic acid, carboxylate, carboxamide, ester and combinations thereof; R2 is selected from alkyl, substituted alkyl, carboxylic acid, carboxylate, carboxamide, sulfonyl, sulfonamide and combinations thereof; and derivatives and metabolites thereof. Further provided are methods of using a compound of formula I to prevent and/or treat a subject having a condition characterized by unwanted cell proliferation. Also provided are pharmaceutical compounds comprising one or more compounds of formula I, or derivatives or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: April 27, 2010Publication date: October 28, 2010Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Ching-Shih Chen, Dasheng Wang
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Publication number: 20100267820Abstract: Vitamin E succinate derivatives according to formula I: are described. These compounds can be included in pharmaceutical compositions, and can be used for the treatment of cancers such as metastatic cancer and as antiadhesive agents.Type: ApplicationFiled: April 16, 2010Publication date: October 21, 2010Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Ching-Shih Chen, Dasheng Wang, Samuel K. Kulp
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Publication number: 20100267673Abstract: Tocopheryl succinate derivatives according to formula I: are described. These compounds increase the activity of protein phosphatase 2A, can be included in pharmaceutical compositions, and can be used for the treatment of androgen receptor-dependent cancers such as prostate cancer.Type: ApplicationFiled: April 13, 2010Publication date: October 21, 2010Applicant: THE OHIO SATE UNIVERSITY RESEARCH FOUNDATIONInventors: Ching-Shih Chen, Dasheng Wang, Samuel K. Kulp
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Publication number: 20100256072Abstract: The invention provides for methods of treating a mammal who has a BCR/ABL-mediated leukemia, including chronic myelogenous leukemia (CML), particularly the blast crisis stage of CML, Philadelphia-positive acute lymphoblastic leukemia (Ph?-ALL), and refractory leukemias. The invention also provides for compounds for the treatment of these leukemias and methods of identifying anti-leukemic agents.Type: ApplicationFiled: March 24, 2006Publication date: October 7, 2010Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Danilo Perrotti, Paolo Neviani, Ramasamy Santhanam, John C. Byrd, Guido Marcucci, Natarajan Muthusamy, Ching-Shih Chen
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Patent number: 7807705Abstract: Compounds and methods for treating cancer and inducing apoptosis in unwanted rapidly proliferating cells. The compounds are shown in formula I: wherein X is hydroxyl or amino; Y is carboxyl or sulfonyl; R1, R2, R3, and R4 can be the same or different and are selected from hydrogen, halogen, methoxy, trifluoromethyl, hydroxyl and combinations thereof, R5, R6, and R7 may be the same or different and are selected from hydrogen, chloro, bromo, nitro, phenyl, amino, methoxy, and combinations thereof, and derivatives or metabolites thereof.Type: GrantFiled: May 9, 2008Date of Patent: October 5, 2010Assignee: The Ohio State University Research FoundationInventors: Ching-Shih Chen, Dasheng Wang, Jing-Ru Weng
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Publication number: 20100168184Abstract: Bcl-xL/Bcl-2 binding inhibitors useful in the treatment of unwanted proliferating cells, including cancers and precancers, in subjects in need of such treatment. Also provided are methods of treating a subject having unwanted proliferating cells comprising administering a therapeutically effective amount of a Bcl-xL/Bcl-2 binding inhibitor described herein to a subject in need of such treatment. Also provided are methods of preventing the proliferation of unwanted proliferating cells, such as cancers and precancers, in a subject comprising the step of administering a therapeutically effective amount of a Bcl-xL/Bcl-2 binding inhibitor described herein to a subject at risk of developing a condition characterized by unwanted proliferating cells.Type: ApplicationFiled: January 5, 2010Publication date: July 1, 2010Inventors: Ching-Shih Chen, Chung-Wai Shiau
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Patent number: 7746626Abstract: A moving element having secondary keyboard for a portable electronic device is placed between a first member and a second member of the device for providing different keyboard sets to improve readability of text when in different operating configurations. When the second member slides out laterally relative to the first member, the moving element remains stayed in the first member, not moving with the second member. When the second member slides out vertically relative to the first member, the moving element slides with the second member along the sliding groove on the first member, and the moving element is exposed on top of the second member to present a concise dialing keyboard. The secondary keyboard contacts corresponding buttons of a primary keyboard directly. Thus, there is no need to provide additional circuit module exclusively for the secondary keyboard such that the cost and volume can be reduced.Type: GrantFiled: October 23, 2008Date of Patent: June 29, 2010Assignee: HTC CorporationInventors: Chih-Kuang Wang, Ching-Shih Chen
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Patent number: 7714005Abstract: Bcl-xL/Bcl-2 binding inhibitors useful in the treatment of unwanted proliferating cells, including cancers and precancers, in subjects in need of such treatment. Also provided are methods of treating a subject having unwanted proliferating cells comprising administering a therapeutically effective amount of a Bcl-xL/Bcl-2 binding inhibitor described herein to a subject in need of such treatment. Also provided are methods of preventing the proliferation of unwanted proliferating cells, such as cancers and precancers, in a subject comprising the step of administering a therapeutically effective amount of a Bcl-xL/Bcl-2 binding inhibitor described herein to a subject at risk of developing a condition characterized by unwanted proliferating cells.Type: GrantFiled: December 22, 2005Date of Patent: May 11, 2010Assignee: The Ohio State University Research FoundationInventors: Ching-Shih Chen, Chung-Wai Shiau
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Publication number: 20100087232Abstract: A portable electronic device having a first body, a second body, and a moving mechanism is provided. The moving mechanism is disposed between the first body and the second body such that the second body is moveable between a first position and a second position. In the first position, the second body is stacked on the first body. In the second position, top surfaces of the first body and second body are substantially coplanar.Type: ApplicationFiled: April 6, 2009Publication date: April 8, 2010Applicant: HTC CORPORATIONInventors: Chih-Shan Yeh, Ching-Shih Chen
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Patent number: 7669289Abstract: A dual-axis hinge includes at least a connecting section, an upper hinge and a lower hinge. The connecting section has two sides orthogonally connected to the upper and lower hinges respectively. The connecting section has a circuit cavity that communicates with circuit outlets of the upper and lower hinges to form a passage for accommodating a transmission circuit. The upper hinge is connected to a first sleeve for joining the top cover of a folding electronic product, and the lower hinge is connected to a second sleeve for joining the body of the folding electronic product. These connections enable the top cover to rotate in at least two different directions.Type: GrantFiled: September 7, 2006Date of Patent: March 2, 2010Assignee: HTC CorporationInventors: Chin-Chung Shih, Yi-Shen Wang, Ching-Shih Chen, Yun-Long Tun, Ming-San Huang, John C. Wang
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Publication number: 20100027224Abstract: An electronic device including a first body, a second body, a connecting mechanism, and an input unit is provided. The second body is movably disposed on the first body. The connecting mechanism is disposed in the first body. The input unit is movably disposed on the first body, wherein the connecting mechanism connects the input unit and the second body. When the second body moves from a first position to a second position relative to the first body, the second body drives the input unit to move from a third position to a fourth position relative to the first body through the connecting mechanism.Type: ApplicationFiled: February 27, 2009Publication date: February 4, 2010Applicant: HTC CORPORATIONInventors: Chih-Kuang Wang, Ching-Liang Chiang, Ching-Shih Chen
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Publication number: 20100022655Abstract: Methods—for treatment and prevention of lymphoid malignancies, including, but not limited to acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), B-cell lymphoma, Acute Myeloid leukemia (AML), and mantle cell lymphoma (MCL). The methods include administration of a therapeutically effective amount of FTY720 (2-Amino-2-[2-(4-octylphenyl)ethyl]propane 1,3-diol hydrochloride) or a derivative, pharmaceutically acceptable salt thereof, or a prodrug thereof to a subject.Type: ApplicationFiled: June 1, 2007Publication date: January 28, 2010Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: John C. Byrd, Danilo Perrotti, Ching-Shih Chen, James T. Dalton, Frank Frissora, Xiaobin Zhao, Qing Liu, Natarajan Muthusamy
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Publication number: 20090291992Abstract: Compounds of the thiazolidinedione family are provided and shown to be effective androgen receptor ablative agents that can be used in methods of treating or preventing cancer or precancer, including prostate cancer. Also provided are methods of treating or preventing cancer by administering a therapeutically effective amount of one of the androgen receptor ablative agents to a subject in need of such treatment.Type: ApplicationFiled: February 20, 2009Publication date: November 26, 2009Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Ching-Shih Chen, Dasheng Wang, Jian Yang
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Publication number: 20090281328Abstract: A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I: wherein X is selected from the group consisting of alkyl and haloalkyl; Ar is an aryl radical selected from the group consisting of phenyl, biphenyl, naphthyl, anthryl, phenanthryl, and fluorenyl; and wherein Ar is optionally substituted with one or more radicals selected from the group consisting of halo, C1-C4 alkyl, C1-C4 haloalkyl, azido, C1-C4 azidoalkyl, aryl, alkylaryl, haloaryl, haloalkylaryl, and combinations thereof; and R is selected from the group consisting of nitrile, acetonitrile, ethylnitrile, propylnitrile, carboxamide, amidine, tetrazole, oxime, hydrazone, acetamidine, aminoacetamide, guanidine, and urea. Also provided are methods of using the compounds for the treatment and prevention of cancer in humans.Type: ApplicationFiled: June 2, 2009Publication date: November 12, 2009Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventor: Ching-Shih Chen
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Patent number: 7595980Abstract: A multi-configuration portable electronic device including a first body, a second body, a dual-axis hinge and at least a guiding module is provided. The dual-axis hinge has a first axis pivotally coupled to the first body and a second axis pivotally coupled to the second body. The guiding module prevents the first axis and the second axis from acting simultaneously. The guiding module includes a track disposed in the first body and a slide connected with the second body. The slide has an interaction force with the track so that the slide can move from the second body to couple with the track.Type: GrantFiled: October 3, 2006Date of Patent: September 29, 2009Assignee: HTC CorporationInventors: John C. Wang, Ching-Shih Chen, Chin-Chung Shih, Yun-Long Tun, Yi-Shen Wang, Ming-San Huang
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Patent number: 7576116Abstract: A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I: wherein X is selected from the group consisting of alkyl and haloalkyl; Ar is an aryl radical selected from the group consisting of phenyl, biphenyl, naphthyl, anthryl, phenanthryl, and fluorenyl; and wherein Ar is optionally substituted with one or more radicals selected from the group consisting of halo, C1-C4 alkyl, C1-C4 haloalkyl, azido, C1-C4 azidoalkyl, aryl, alkylaryl, haloaryl, haloalkylaryl, and combinations thereof, and R is selected from the group consisting of nitrile, acetonitrile, ethylnitrile, propylnitrile, carboxamide, amidine, tetrazole, oxime, hydrazone, acetamidine, aminoacetamide, guanidine, and urea. Also provided are methods of using the compounds for the treatment and prevention of cancer in humans.Type: GrantFiled: September 28, 2007Date of Patent: August 18, 2009Assignee: The Ohio State University Research FoundationInventor: Ching-Shih Chen
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Patent number: 7573728Abstract: A dual-axis circuit board is disclosed. The circuit board includes at least an upper circuit board, a lower circuit board, and a connecting circuit board. The upper circuit board connects to the circuit in a top cover of the folding electronic apparatus, and the lower circuit board connects to the circuit in the body of the folding electronic apparatus. The angle between the folding directions of the upper and lower circuit board is approximately 90 degrees.Type: GrantFiled: November 1, 2006Date of Patent: August 11, 2009Assignee: HTC CorporationInventors: Ching-Shih Chen, Chin-Chung Shih, Yun-Long Tun, Ming-San Huang, Yi-Shen Wang, John C. Wang
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Patent number: 7566787Abstract: Cyclin D1 ablative agents and methods of using these agents in the treatment of cancers, and particularly breast cancer. Also provided are methods of treating cancer, the method comprising administering a therapeutically effective amount of one of the cyclin D1 ablative agents described herein to a subject in need of such treatment. Also provided are methods of treating cancers comprising using the cyclin D1 ablative agents described herein in combination therapies with existing chemotherapeutic agents.Type: GrantFiled: December 22, 2005Date of Patent: July 28, 2009Assignee: The Ohio State UniversityInventor: Ching-Shih Chen