Abstract: A robust human cell culture model permissive to both SARS-COV-2 variants and MERS-COV is critical for assessment and validation of antivirals. Human alveolar A549 cells are regarded as a valuable model for respiratory virus infection. SARS-COV-2 uses the angiotensin converting enzyme 2 (ACE2) receptor for viral entry and the transmembrane serine protease 2 (TMPRSS2) to prime the SARS-COV-2 spike protein. By contrast, MERS-COV utilizes the dipeptidyl peptidase 4 receptor (DPP4) to enter the target cells. Three of which are negligibly expressed in A549. Disclosed herein is a generation of a robust human cell model that carries DPP4, ACE2, and TMPRSS2 receptor expressions. By transducing Dpp4 into A549-ACE2plusC3 cells (ACE2+/TMPRSS2+), the resulting cells expressing DPP4, ACE2 and TMPRSS2 (“ACE2plusC3D4”) are highly susceptible to MERS-COV and SARS-CoV-2 omicron infection. This ACE2plusC3D4 cell model can be applied for evaluation of antiviral drugs and potentially developed for high-throughput screening.

Abstract: A foaming apparatus for a paper container (90), including: a main body (10), a delivery mechanism, a plurality of supports (30), a heating mechanism (40), a cooling mechanism (50), a feeding mechanism (60), and a pick-up mechanism (70). The main body (10) is divided into a feeding and pick-up area (13), a preheating area (14), a heating area (15) and a cooling area (16) on a horizontal plane; the delivery mechanism includes a chain (21) in closed circulation; each of the supports (30) is provided with a supporting portion (32) and a base (31); the heating mechanism (40) is disposed on the preheating area (14) and the heating area (15) so as to heat same; the cooling mechanism (50) is disposed on the cooling area (16) so as to cool same; the feeding mechanism (60) and the pick-up mechanism (70) are separately disposed above the feeding and pick-up area (13).

Abstract: Disclosed are a heating culture device used to provide an environment with a vertical temperature difference and a method of using the heating culture device. The heating culture device is provided for accommodating and heating a cell separation device which carries living cells having flagella and capable of moving autonomously and has a film for passing through the living cells and partitioning the cell separating device into upper and lower chambers. The heating culture device includes a carrying assembly, a chip carrier box, a case assembly and a control assembly. When a cover of the heating culture device is covered during operation, the control assembly can control driving state of an upper electric heating plate at the cover according to the temperature of a heat spreader set on the cover; and control a fan at the bottom according to the temperature at the bottom of the chip carrier box.

Abstract: The invention provides a single-photon detector that includes a superconducting wire made from a high quality and uniform superconducting film with a higher critical temperature. A reflector or a multilayered reflector with high reflectivity, preferably a nitride-based distributed Bragg reflector, is provided to reflect an incident light to the superconducting wire. A surface-plasmon wavelength-selective surface may be further provided above the superconducting wire to resonantly transmits the incident light within a selective passband, making the single-photon detector operable in the ultraviolet, visible, and infrared wavelength bands. In addition, a large area of superconducting film with high level of uniformity is grown to achieve the up scaling of the single-photon detector and a single-photon detector array.

Abstract: The invention provides a single-photon detector that includes a superconducting wire made from a high quality and uniform superconducting film with a higher critical temperature. A reflector or a multilayered reflector with high reflectivity, preferably a nitride-based distributed Bragg reflector, is provided to reflect an incident light to the superconducting wire. A surface-plasmon wavelength-selective surface may be further provided above the superconducting wire to resonantly transmits the incident light within a selective passband, making the single-photon detector operable in the ultraviolet, visible, and infrared wavelength bands. In addition, a large area of superconducting film with high level of uniformity is grown to achieve the up scaling of the single-photon detector and a single-photon detector array.

Abstract: A detection system and method for the migrating cell is provided. The system is configured to detect a migrating cell combined with an immunomagnetic bead. The system includes a platform, a microchannel, a magnetic field source, a coherent light source and an optical sensing module. The microchannel is configured to allow the migrating cell to flow in it along a flow direction. The magnetic field source is configured to provide magnetic force to the migrating cell combined with the immunomagnetic bead. The magnetic force includes at least one magnetic force component and the magnetic force component is opposite to the flow direction of the microchannel. The coherent light source is configured to provide the microchannel with the coherent light. The optical sensing module is configured to receive the interference light caused by the coherent light being reflected by the sample inside the microchannel.

Abstract: A sperm sorting method is provided. The sperm sorting method includes the following steps: providing a porous layer with a first side and a second side opposite to the first side; disposing an unsorted sperm group at the second side; forming a temperature difference between the first side and the second side; and collecting a sorted sperm group which arrives the first side and passes through the porous layer from the second side based on the temperature difference and overcoming gravity.

Abstract: This disclosure relates to an apparatus and method for sorting motile sperms from crude semen. the enrichment of a population of spermatozoa with capacitated spermatozoa can be achieved by providing a 1-to-4-degree vertical temperature difference in combination with the swim-up method.

Abstract: A sperm sorting device adapted to collaborate with a temperature controlling component is provided. The sperm sorting device includes an upper portion, a lower portion and a porous layer. The upper portion is formed with an upper chamber. The lower portion is formed with a lower chamber. The upper chamber and the lower chamber are disposed vertically. The temperature controlling component is adapted to be disposed outside the upper portion or the lower portion to make the temperature of the upper chamber higher than the lower chamber. The porous layer is disposed between the upper chamber and the lower chamber. The porous layer is adapted to allow sperms to pass through from the lower chamber to the upper chamber and adapted to form a temperature difference between the upper chamber and the lower chamber. Besides, a temperature difference device adapted for the sperm sorting device is also provided.

Abstract: A prediction model training apparatus and method are provided. The apparatus classifies a plurality of data into a normal situation data set and a non-normal situation data set, wherein each of the data comprises a plurality of first features. The apparatus trains a first prediction model based on the normal situation data set and a plurality of third features among the first features. The apparatus inputs the non-normal situation data set to the first prediction model to generate a first stage prediction value. The apparatus adds the first stage prediction value to the non-normal situation data set. The apparatus trains a second prediction model based on the non-normal situation data set and the first features.

Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically bind to ?-toxin of Staphylococcal aureus. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by Staphylococcal aureus infection in a subject in need, and a method for detecting ?-toxin of Staphylococcal aureus in a sample.

Abstract: A foaming apparatus for a paper container (90), including: a main body (10), a delivery mechanism, a plurality of supports (30), a heating mechanism (40), a cooling mechanism (50), a feeding mechanism (60), and a pick-up mechanism (70). The main body (10) is divided into a feeding and pick-up area (13), a preheating area (14), a heating area (15) and a cooling area (16) on a horizontal plane; the delivery mechanism includes a chain (21) in closed circulation; each of the supports (30) is provided with a supporting portion (32) and a base (31); the heating mechanism (40) is disposed on the preheating area (14) and the heating area (15) so as to heat same; the cooling mechanism (50) is disposed on the cooling area (16) so as to cool same; the feeding mechanism (60) and the pick-up mechanism (70) are separately disposed above the feeding and pick-up area (13).

Abstract: A method of using Neoandrographolide for lowering blood sugar, lowering blood lipid, improving liver function and improving renal function. The method includes preparing a composition comprising Neoandrographolide as the active ingredient, and administering the composition to lower the blood sugar or blood lipid of a user, to prevent a decrease in liver function of a user, or to improve the renal function of a user. The Neoandrographolide is the only active ingredient in the composition.

Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically bind to ?-toxin of Staphylococcal aureus. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by Staphylococcal aureus infection in a subject in need, and a method for detecting ?-toxin of Staphylococcal aureus in a sample.

Abstract: An environmentally-friendly cup and method of making the same are provided. The environmentally-friendly cup includes a cup body and a cup base. The cup body is formed by curling a paper material that has a first and a second portion. The second portion has a first and a second straight side. The first portion is connected to the first straight side of the second portion and is curled into a straw. The straw is adhesively bonded to the second straight side of the second portion such that the second portion is curled into a tubular wall with a top opening and a bottom opening. The top end of the straw juts out of the top opening. The straw is directly formed on the cup body and therefore can be easily carried as an integral part of the environmentally-friendly cup without getting lost.

Abstract: A method of using Neoandrographolide for lowering blood sugar, lowering blood lipid, improving liver function and improving renal function. The method includes preparing a composition comprising Neoandrographolide as the active ingredient, and administering the composition to lower the blood sugar or blood lipid of a user, to prevent a decrease in liver function of a user, or to improve the renal function of a user. The Neoandrographolide is the only active ingredient in the composition.

Abstract: A lid is provided for covering or sealing a cup by engaging a rim flange of the cup. The lid includes a top portion and an annular side plate which extends downwardly from periphery of the top portion. The plate is formed with a hole. An engagement plate is disposed on the side plate. A bottom edge of the engagement plate is connected to the plate. A top edge of the engagement plate stretches upwardly along the hole, so that the engagement plate is located in the hole. The plates are flexible. As such, the engagement plate can be pressed and bent inwardly when the lid covers a cup. The engagement plate would then engage with the rim flange of the cup so as to enhance engagement of the lid and the cup.

Abstract: A flash memory storage device, a controller thereof, and a programming management method thereof are provide for the flash memory storage device including a flash memory chip, wherein at least a first thread and a second thread are to be implemented within the flash memory storage device. The method includes defining a predetermined programming unit and receiving a first write command sent by a host. The method also includes distributing a control right of the flash memory chip to the first thread if the first write command is determined to be executed by the first thread, and controlling the first thread to release the control right of the flash memory chip after the first thread finishes a programming operation of the predetermined programming unit.

Abstract: A temperature control equipment is capable of controlling a tested object to a predetermined temperature. The temperature control equipment includes a thermal conducting plate, a temperature regulating module, a carrier plate, and a thermoelectric cooling module. The temperature regulating module is thermally connected to the thermal conducting plate for regulating the thermal conducting plate to a reference temperature. The carrier plate is used to accommodate the tested object. The thermoelectric cooling module is thermally connected between the thermal conducting plate and the carrier plate for controlling the tested object to the predetermined temperature via the carrier plate based on the reference temperature.

Abstract: A lid is provided for covering or sealing a cup by engaging a rim flange of the cup. The lid includes a top portion and an annular side plate which extends downwardly from periphery of the top portion. The plate is formed with a hole. An engagement plate is disposed on the side plate. A bottom edge of the engagement plate is connected to the plate. A top edge of the engagement plate stretches upwardly along the hole, so that the engagement plate is located in the hole. The plates are flexible. As such, the engagement plate can be pressed and bent inwardly when the lid covers a cup. The engagement plate would then engage with the rim flange of the cup so as to enhance engagement of the lid and the cup.