Patents by Inventor Ching-yun Chen
Ching-yun Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240034979Abstract: Provided is a bioreactor apparatus including: a liquid storage chamber for storing a culture medium; a pump for providing pressure to drive the flow of the culture medium; a plurality of culture chambers providing an accommodating space to accommodate the culture medium and a cell to be cultured; and a pipeline connecting the liquid storage chamber, the pump, and the culture chamber to form a closed loop. Also provided is a bioreactor system including the bioreactor apparatus of the present disclosure, the culture medium, and a cell. Further provided is a method for culturing a cell or an organoid by the bioreactor apparatus of the present disclosure. The bioreactor apparatus, bioreactor system, and method of the present disclosure can form a biomimetic circulatory system, which is beneficial for simulating and evaluating the complex microenvironment and physiological mechanism in the living body.Type: ApplicationFiled: July 26, 2023Publication date: February 1, 2024Applicant: NATIONAL CENTRAL UNIVERSITYInventors: Ching-Yun CHEN, Feng-Huei LIN, Jui-Sheng SUN, Cherng-Jyh KE, Fu-Chiang YEH, Chun-Yi PENG, Jia-Ci JHANG, Kai-Wei LIN, Qi-Hong HONG, Yu-Syuan DING
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Publication number: 20240024868Abstract: Provided is a microfluidic detection device, including a base with a microfluidic channel structure formed on the base and a lid covering the base. The microfluidic channel structure includes a sample well for loading a sample, a detection well having a first reagent for reacting with the sample, and a channel connecting the sample well and the detection well. The detection well has a recess deeper than the channel, and the base includes a protrusion corresponding to the recess to form a space between the protrusion and the recess. Also provided is a method for rapid diagnostic testing by the microfluidic detection device.Type: ApplicationFiled: July 25, 2023Publication date: January 25, 2024Inventors: Ching-Yun Chen, Cherng-Jyh Ke, Shih-Tien Hsu, Ching-Wen Tsai, Si-Ting Wu, Yi-Hsuan Tung, Hsin-I Chiu, Sheng-Wen Chang, Jing-Ke Chen, Yueh-Teng Tsai, Ching Yu, Jian-Hua Chang
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Publication number: 20230201266Abstract: The present disclosure provides a method for treating arthritis by using a stem cell preparation. The stem cell preparation of the present disclosure can effectively delay cartilage degeneration caused by arthritis, and it is confirmed by whole blood analysis and blood biochemical analysis that the stem cell preparation in the form of three-dimensional stem cell spheres provides a safe treatment for arthritis. The present disclosure also provides a method for preparing the stem cell preparation.Type: ApplicationFiled: September 9, 2021Publication date: June 29, 2023Inventors: Feng-Huei Lin, Che-Yung Kuan, Yu-Ying Lin, Ching-Yun Chen, Zhi-Yu Chen, I-Hsuan Yang, Ming-Hsi Chuang, Po-Cheng Lin, Chia-Hsin Lee, Kai-Ling Zhang, Pei-Syuan Chao, Wan-Sin Syu, Chun-Hung Chen, Ting-Ju Wang
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Publication number: 20230131120Abstract: The present invention relates to a method for body weight control in a subject in need thereof, comprising administering an effective amount of a thiolated chitosan to the subject. In particular, the thiolated chitosan of the present invention comprises a plurality of thiol groups covalently bonded to a chitosan moiety thereof. The thiolated chitosan of the present invention can be orally administered, which is effective in slowing down body weight gain and has good biocompatibility.Type: ApplicationFiled: October 24, 2022Publication date: April 27, 2023Applicant: National Health Research InstitutesInventors: Feng-Huei LIN, Ching-Yun Chen
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Publication number: 20230012279Abstract: A hydrogel composition, a hydrogel biomedical material, a method for facilitating regeneration of a bone and a manufacturing method of a hydrogel composition are provided. The hydrogel composition includes a first deionized water, a gel powder, a transglutaminase mixture and a hyaluronic acid powder. The gel powder includes gelatin and alginic acid. The first deionized water, the gel powder, the transglutaminase mixture and the hyaluronic acid powder are evenly mixed. Based on the hydrogel composition being 100 wt %, the first deionized water is 95 wt % to 98.46 wt %, the gel powder is 1 wt % to 3 wt %, the transglutaminase mixture is 0.04 wt % to 0.15 wt %, and the hyaluronic acid powder is 0.5 wt % to 1.5 wt %.Type: ApplicationFiled: June 30, 2022Publication date: January 12, 2023Applicant: China Medical UniversityInventors: Cherng-Jyh Ke, Feng-Huei Lin, Chun-Hsu Yao, Jui-Sheng Sun, Ching-Yun Chen
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Publication number: 20220356434Abstract: A magnetic cell biocarrier combined with a powerless bioreactor system comprising a biocarrier, a powerless bioreactor, and a magnetic field device. The biocarrier can detach the cells through temperature regulation and can be adsorbed by the magnetic field device to stabilize at the bottom of the gooseneck cell culture tank; the powerless bioreactor comprises a microinfusion element, a culture fluid collection element, and a gooseneck cell culture tank; the internal space of the gooseneck cell culture tank is interconnected with the microinfusion element and the culture fluid collection element, the microinfusion element slowly injects fresh culture medium When the culture medium in the gooseneck cell culture tank is above an overflow position, the cell metabolites can be automatically discharged to the culture fluid collection element by the interconnected vessels to reduce the risk of cell contamination.Type: ApplicationFiled: July 21, 2021Publication date: November 10, 2022Inventors: FENG-HUEI LIN, CHING-YUN CHEN, YUN-YI WANG, YUN-MING WANG
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Patent number: 11218482Abstract: A two-way information exchange system, which allows a requesting client employing an intelligent communication device to conduct information exchange with a target client, includes a communication module, a memory module, an authentication module, a selection module, a central processing module, an evaluation module, and an authorization module. The central processing module can search for one online client meeting the exchange condition provided from the requesting client to be served as a primary target client, and search the memory module for one or more clients meeting the exchange condition to be served as false target clients. The central processing module can send the identity data of the target clients to the intelligent communication device, and receive/send exchange information between the clients.Type: GrantFiled: December 27, 2017Date of Patent: January 4, 2022Assignee: Among Net Co., Ltd.Inventor: Ching-Yun Chen
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Publication number: 20210336957Abstract: A two-way information exchange system, which allows a requesting client employing an intelligent communication device to conduct information exchange with a target client, includes a communication module, a memory module, an authentication module, a selection module, a central processing module, an evaluation module, and an authorization module. The central processing module can search for one online client meeting the exchange condition provided from the requesting client to be served as a primary target client, and search the memory module for one or more clients meeting the exchange condition to be served as false target clients. The central processing module can send the identity data of the target clients to the intelligent communication device, and receive/send exchange information between the clients.Type: ApplicationFiled: December 27, 2017Publication date: October 28, 2021Inventor: Ching-Yun Chen
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Publication number: 20200197572Abstract: The present invention relates to a three-dimensional (3D) tissue-like implant for transplanting to a subject in need comprising a cell cluster comprising mesenchymal stem cells (MSCs) and specific cells differentiated therefrom. The present invention also relate to a method of preparing a 3D-tissue-like implant from MSCs, particularly by seeding MSCs in alginate scaffolds and culturing the alginate scaffolds with MSCs in a 3-D perfusion condition. Further, the present invention provides a method for treating a defect in a recipient patient in need by administering a 3D tissue-like implant as described herein to the patient at a defective site e.g. a bone defective site.Type: ApplicationFiled: December 24, 2018Publication date: June 25, 2020Applicant: National Health Research InstitutesInventors: Feng-Huei LIN, Jui-Sheng SUN, Ching-Yun CHEN, Chih-Ying CHI
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Patent number: 10066208Abstract: The present invention is related to a kit comprising: (a) a mesenchymal stem cell; (b) a gelatin-hyaluronan-chondroitin tri-copolymer scaffold; (c) a kartogenin; and (d) a bioreactor. The present invention is also related to a method for promoting differentiation of a mesenchymal stem cell into cartilage tissue, comprising: (a) culturing the mesenchymal stem cell on a gelatin- hyaluronan-chondroitin tri-copolymer scaffold in the presence of a kartogenin; and (b) culturing the mesenchymal stem cell and the gelatin-hyaluronan-chondroitin tri-copolymer scaffold in a bioreactor.Type: GrantFiled: April 30, 2015Date of Patent: September 4, 2018Assignee: NATIONAL TAIWAN UNIVERSITYInventors: Feng-Huei Lin, Jui-Sheng Sun, Chunching Li, Ching-Yun Chen, Cherng-Jyh Ke
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Publication number: 20160145574Abstract: The present invention is related to a kit comprising: (a) a mesenchymal stem cell; (b) a gelatin-hyaluronan-chondroitin tri-copolymer scaffold; (c) a kartogenin; and (d) a bioreactor. The present invention is also related to a method for promoting differentiation of a mesenchymal stem cell into cartilage tissue, comprising: (a) culturing the mesenchymal stem cell on a gelatin- hyaluronan-chondroitin tri-copolymer scaffold in the presence of a kartogenin; and (b) culturing the mesenchymal stem cell and the gelatin-hyaluronan-chondroitin tri-copolymer scaffold in a bioreactor.Type: ApplicationFiled: April 30, 2015Publication date: May 26, 2016Applicant: NATIONAL TAIWAN UNIVERSITYInventors: Feng-Huei Lin, Jui-Sheng Sun, Chunching Li, Ching-Yun Chen, Cherng-Jyh Ke
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Publication number: 20120241673Abstract: The present invention discloses a tunable fluorescent gold nanocluster. The tunable fluorescent gold nanocluster is formed by mixing gold trichloride (AuCl3) with toluene solvent without reductant. The tunable fluorescent gold nanocluster emits blue fluorescence that can be red shifted through ultrasonic vibration. The spectral region of the tunable fluorescent gold nanocluster is from 400 nm to 550 nm.Type: ApplicationFiled: April 30, 2012Publication date: September 27, 2012Applicant: CHUNG YUAN CHRISTIAN UNIVERSITYInventors: Walter H. Chang, Cherng-Jyh Ke, Cheng-An Lin, Ching-Yun Chen
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Patent number: 8263668Abstract: The present invention discloses a tunable fluorescent gold nanocluster. The tunable fluorescent gold nanocluster is formed by mixing gold trichloride (AuCl3) with toluene solvent without reductant. The tunable fluorescent gold nanocluster emits blue fluorescence that can be red shifted through ultrasonic vibration. The spectral region of the tunable fluorescent gold nanocluster is from 400 nm to 550 nm.Type: GrantFiled: July 8, 2009Date of Patent: September 11, 2012Assignee: Chung Yuan Christian UniversityInventors: Walter Hong-Shong Chang, Cherng-Jyh Ke, Cheng-An Lin, Ching-Yun Chen
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Publication number: 20100163806Abstract: The present invention discloses a tunable fluorescent gold nanocluster. The tunable fluorescent gold nanocluster is formed by mixing gold trichloride (AuCl3) with toluene solvent without reductant. The tunable fluorescent gold nanocluster emits blue fluorescence that can be red shifted through ultrasonic vibration. The spectral region of the tunable fluorescent gold nanocluster is from 400 nm to 550 nm.Type: ApplicationFiled: July 8, 2009Publication date: July 1, 2010Applicant: CHUNG YUAN CHRISTIAN UNIVERSITYInventors: Walter H. Chang, Cherng-Jyh Ke, Cheng-An Lin, Ching-Yun Chen
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Patent number: 7597530Abstract: A method for conveying an object and a conveying apparatus are provided. The method includes steps of loading a first object at a first position by a transmission apparatus, loading a second object onto a carrying platform, providing a supporter having a first holder and a second holder, unloading the second object by the transmission apparatus, and adjusting a position of the supporter relative to that of the carrying platform for locating the first object on the carrying platform. The provided method and conveying apparatus adopts a single supporter for conveying the objects. The object standby for being processed and the processed one can be loaded and unloaded with greater safety and stability thereby.Type: GrantFiled: December 2, 2004Date of Patent: October 6, 2009Assignee: Hannstar Display CorporationInventors: Po-nan Tai, Ching-yun Chen, Hung-wei Cheng
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Publication number: 20050281658Abstract: A method for conveying an object and a conveying apparatus are provided. The method includes steps of loading a first object at a first position by a transmission apparatus, loading a second object onto a carrying platform, providing a supporter having a first holder and a second holder, unloading the second object by the transmission apparatus, and adjusting a position of the supporter relative to that of the carrying platform for locating the first object on the carrying platform. The provided method and conveying apparatus adopts a single supporter for conveying the objects. The object standby for being processed and the processed one can be loaded and unloaded with greater safety and stability thereby.Type: ApplicationFiled: December 2, 2004Publication date: December 22, 2005Inventors: Po-nan Tai, Ching-yun Chen, Hung-wei Cheng
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Publication number: 20050134557Abstract: An ACF assembly apparatus for a display panel and an assembly method thereof. The ACF assembly method includes the following steps. An adhesive member with an ACF and a separator is first provided. The adhesive member is then attached to the display panel. The separator is removed from the adhesive member attached to the display panel while the ACF remained on the display panel is detected by a moveable sensor.Type: ApplicationFiled: December 19, 2003Publication date: June 23, 2005Inventors: Xu-Wen Feng, Ching-Yun Chen