Abstract: The present disclosure relates to systems and methods for cellular imaging and identification through the use of a light sheet flow cytometer. In one implementation, a light sheet flow cytometer may include a light source configured to emit light having one or more wavelengths, at least one optical element configured to form a light sheet from the emitted light, a microfluidic channel configured to hold a sample, and an imaging device. The imaging device may be adapted to forming 3-D images of the sample such that identification tags attached to the sample are visible.

Abstract: Systems and methods for acquiring images of a sample are provided. According to an aspect of the invention, a system includes a first light source that emits first light having a first wavelength as a temporally continuous beam; a second light source that emits second light having a second wavelength as a temporally modulated beam; and a scanning mirror that raster scans the first light across a sample during a raster scan period, and projects a structured light pattern of the second light onto the sample during the raster scan period. A first image of the sample is generated from at least a portion of the first light that is backscattered from the sample during the raster scan period, and a second image of the sample is generated from at least a portion of the second light that is backscattered from the sample during the raster scan period.

Abstract: The technology described herein is directed to a fundus camera and, more specifically, to a fundus camera having a display that projects active visual alignment stimuli onto an eye of an examinee via one or more components of an optimal assembly. The active visual alignment stimuli are dynamically adjusted to guide an examinee toward optical alignment for fundus imaging.

Abstract: Embodiments may include a method to estimate motion data based on test image data sets. The method may include receiving a training data set comprising a plurality of training data elements. Each element may include an image data set and a motion data set. The method may include training a machine learning model using the training data set, resulting in identifying one or more parameters of a function in the machine learning model based on correspondences between the image data sets and the motion data sets. The method may further include receiving a test image data set. The test image data set may include intensities of pixels in a deep-tissue image. The method may include using the trained machine learning model and the test image data set to generate output data for the test image data set. The output data may characterize motion represented in the test image data set.

Abstract: A solid state electronic spin system contains electronic spins disposed within a solid state lattice and coupled to an electronic spin bath and a nuclear spin bath, where the electronic spin bath composed of electronic spin impurities and the nuclear spin bath composed of nuclear spin impurities. The concentration of nuclear spin impurities in the nuclear spin bath is controlled to a value chosen so as to allow the nuclear spin impurities to effect a suppression of spin fluctuations and spin decoherence caused by the electronic spin bath. Sensing devices such as magnetic field detectors can exploit such a spin bath suppression effect, by applying optical radiation to the electronic spins for initialization and readout, and applying RF pulses to dynamically decouple the electronic spins from the electronic spin bath and the nuclear spin bath.

Abstract: A solid state electronic spin system contains electronic spins disposed within a solid state lattice and coupled to an electronic spin bath and a nuclear spin bath, where the electronic spin bath composed of electronic spin impurities and the nuclear spin bath composed of nuclear spin impurities. The concentration of nuclear spin impurities in the nuclear spin bath is controlled to a value chosen so as to allow the nuclear spin impurities to effect a suppression of spin fluctuations and spin decoherence caused by the electronic spin bath. Sensing devices such as magnetic field detectors can exploit such a spin bath suppression effect, by applying optical radiation to the electronic spins for initialization and readout, and applying RF pulses to dynamically decouple the electronic spins from the electronic spin bath and the nuclear spin bath.

Abstract: A device and a method to measure the concentrations of oxygenated and deoxygenated hemoglobin in tissue around a tumor via near-infrared (NIR) spectroscopy with a photonic mixer device (PMD) is described.

Abstract: Systems and methods are provided for cytometric measurement of blood cells traversing microvasculature single-file in the eye of a subject. A miniature imaging device, having cellular resolution, records image data that can be rendered into a microcirculation time sequence and analyzed to provide useful biological information.

Abstract: A device and a method to measure the concentrations of oxygenated and deoxygenated hemoglobin in tissue around a tumor via near-infrared (NIR) spectroscopy with a photonic mixer device (PMD) is described.

Abstract: A solid state electronic spin system contains electronic spins disposed within a solid state lattice and coupled to an electronic spin bath and a nuclear spin bath, where the electronic spin bath composed of electronic spin impurities and the nuclear spin bath composed of nuclear spin impurities. The concentration of nuclear spin impurities in the nuclear spin bath is controlled to a value chosen so as to allow the nuclear spin impurities to effect a suppression of spin fluctuations and spin decoherence caused by the electronic spin bath. Sensing devices such as magnetic field detectors can exploit such a spin bath suppression effect, by applying optical radiation to the electronic spins for initialization and readout, and applying RF pulses to dynamically decouple the electronic spins from the electronic spin bath and the nuclear spin bath.

Abstract: A device and a method to measure the concentrations of oxygenated and deoxygenated hemoglobin in tissue around a tumor via near-infrared (NIR) spectroscopy with a photonic mixer device (PMD) is described.

Abstract: A solid state electronic spin system contains electronic spins disposed within a solid state lattice and coupled to an electronic spin bath and a nuclear spin bath, where the electronic spin bath composed of electronic spin impurities and the nuclear spin bath composed of nuclear spin impurities. The concentration of nuclear spin impurities in the nuclear spin bath is controlled to a value chosen so as to allow the nuclear spin impurities to effect a suppression of spin fluctuations and spin decoherence caused by the electronic spin bath. Sensing devices such as magnetic field detectors can exploit such a spin bath suppression effect, by applying optical radiation to the electronic spins for initialization and readout, and apply-ing RF pulses to dynamically decouple the electronic spins from the electronic spin bath and the nuclear spin bath.

Abstract: A device and a method to measure the concentrations of oxygenated and deoxygenated hemoglobin in tissue around a tumor via near-infrared (NIR) spectroscopy with a photonic mixer device (PMD) is described.

Abstract: A solid state electronic spin system contains electronic spins disposed within a solid state lattice and coupled to an electronic spin bath and a nuclear spin bath, where the electronic spin bath composed of electronic spin impurities and the nuclear spin bath composed of nuclear spin impurities. The concentration of nuclear spin impurities in the nuclear spin bath is controlled to a value chosen so as to allow the nuclear spin impurities to effect a suppression of spin fluctuations and spin decoherence caused by the electronic spin bath. Sensing devices such as magnetic field detectors can exploit such a spin bath suppression effect, by applying optical radiation to the electronic spins for initialization and readout, and applying RF pulses to dynamically decouple the electronic spins from the electronic spin bath and the nuclear spin bath.

Abstract: Wearable devices configured to detect the presence, concentration, number, or other properties of nanoparticles disposed in subsurface vasculature of a person are provided. The wearable devices are configured to magnetize the nanoparticles at an upstream location of subsurface vasculature and to detect, using a magnetometer, magnetic fields produced by the magnetized nanoparticles at a downstream location of subsurface vasculature. In some embodiments, the nanoparticles are configured to bind to an analyte of interest and detected properties of the magnetized nanoparticles can be used to determine the presence, concentration, or other properties of the analyte.

Abstract: A solid state electronic spin system contains electronic spins disposed within a solid state lattice and coupled to an electronic spin bath and a nuclear spin bath, where the electronic spin bath composed of electronic spin impurities and the nuclear spin bath composed of nuclear spin impurities. The concentration of nuclear spin impurities in the nuclear spin bath is controlled to a value chosen so as to allow the nuclear spin impurities to effect a suppression of spin fluctuations and spin decoherence caused by the electronic spin bath. Sensing devices such as magnetic field detectors can exploit such a spin bath suppression effect, by applying optical radiation to the electronic spins for initialization and readout, and applying RF pulses to dynamically decouple the electronic spins from the electronic spin bath and the nuclear spin bath.

Abstract: A two-dimensional (2D) magneto-optical trap (MOT) for alkali neutral atoms establishes a zero magnetic field along the longitudinal symmetry axis. Two of three pairs of trapping laser beams do not follow the symmetry axes of the quadruple magnetic field and are aligned with a large non-zero degree angles to the longitudinal axis. In a dark-line 2D MOT configuration, there are two orthogonal repumping beams. In each repumping beam, an opaque line is imaged to the longitudinal axis, and the overlap of these two line images creates a dark line volume in the longitudinal axis where there is no repumping light. The zero magnetic field along the longitudinal axis allows the cold atoms maintain a long ground-state coherence time without switching off the MOT magnetic field, which makes it possible to operate the MOT at a high repetition rate and a high duty cycle.

Abstract: Methods and systems are described for spectral decomposition of composite solid-state spin environments through quantum control of electronic spin impurities. ? sequence of spin-control modulation pulses are applied to the electronic spin impurities in the solid-state spin systems. The spectral content of the spin bath that surrounds the electronic spin impurities within the solid-state spin system is extracted, by measuring the coherent evolution and associated decoherence of the spin impurities as a function of number of the applied modulation pulses, and the time-spacing between the pulses. Using these methods, fundamental properties of the spin environment such as the correlation times and the coupling strengths for both electronic and nuclear spins in the spin bath, can be determined.

Abstract: A two-dimensional (2D) magneto-optical trap (MOT) for alkali neutral atoms establishes a zero magnetic field along the longitudinal symmetry axis. Two of three pairs of trapping laser beams do not follow the symmetry axes of the quadruple magnetic field and are aligned with a large non-zero degree angles to the longitudinal axis. In a dark-line 2D MOT configuration, there are two orthogonal repumping beams. In each repumping beam, an opaque line is imaged to the longitudinal axis, and the overlap of these two line images creates a dark line volume in the longitudinal axis where there is no repumping light. The zero magnetic field along the longitudinal axis allows the cold atoms maintain a long ground-state coherence time without switching off the MOT magnetic field, which makes it possible to operate the MOT at a high repetition rate and a high duty cycle.