Abstract: Provided is a method of inhibiting tumor progression in a subject suffering from gastric cancer, including administering to said subject a pharmaceutical composition including an inhibitor of targeting PHF8-c-Jun-PKC?-Src-PTEN axis, or a pharmaceutically acceptable salt thereof. A method of determining a tumor progression state in a subject suffering from gastric cancer is also provided, which comprises providing a sample from the subject; detecting PHF8 expression level in the sample from the subject; and determining the tumor progression state of gastric cancer by the PHF8 expression level, wherein the PHF8 expression level is positively detected from moderate to strong expression indicating the subject suffering a late stage of gastric cancer.

Abstract: The present invention is related to a method for inducing the cancer cell apoptosis or inhibiting the cancer cell migration by inhibiting the expression of ribose-5-phosphate isomerase A.

Abstract: Disclosed is a method for early diagnosis of liver cancer. The method comprises the steps of:(A) providing a sample obtained from a subject; (B) assessing the expression level of four subtypes of ?-mannosidase genes consisting of MAN1C1 in the sample; (C) comparing the expression level of ?-mannosidase genes in the sample with a normal control; and (D) determining whether the subject having a risk of suffering liver cancer in accordance with the result of step (C); wherein while the MAN1C1 expression level of the sample is lower than that in the normal control, the subject is determined to have a risk of suffering liver cancer. Additionally, while MAN1A1, MAN1A2 and MAN1B1 expression levels in the sample are higher than those in control group, the subject is determined to suffer from liver cancer and has a risk of metastasis. In the future, MAN1C1 can be applied to early diagnosis of liver cancer and metastasis, suppression of liver metastasis, and screening agents for treating liver cancer.

Abstract: Disclosed is a method for early diagnosis of liver cancer. The method comprises the steps of: (A) providing a sample obtained from a subject; (B) assessing the expression level of four subtypes of ?-mannosidase genes consisting of MAN1C1 in the sample; (C) comparing the expression level of ?-mannosidase genes in the sample with a normal control; and (D) determining whether the subject having a risk of suffering liver cancer in accordance with the result of step (C); wherein while the MAN1C1 expression level of the sample is lower than that in the normal control, the subject is determined to have a risk of suffering liver cancer. Additionally, while MAN1A1, MAN1A2 and MAN1B1 expression levels in the sample are higher than those in control group, the subject is determined to suffer from liver cancer and has a risk of metastasis.

Abstract: Disclosed is a method for early diagnosis of liver cancer. The method comprises the steps of: (A) providing a sample obtained from a subject; (B) assessing the expression level of four subtypes of ?-mannosidase genes consisting of MAN1C1 in the sample; (C) comparing the expression level of ?-mannosidase genes in the sample with a normal control; and (D) determining whether the subject having a risk of suffering liver cancer in accordance with the result of step (C); wherein while the MAN1C1 expression level of the sample is lower than that in the normal control, the subject is determined to have a risk of suffering liver cancer. Additionally, while MAN1A1, MAN1A2 and MAN1B1 expression levels in the sample are higher than those in control group, the subject is determined to suffer from liver cancer and has a risk of metastasis.

Abstract: The present invention is related to a method for inducing the cancer cell apoptosis or inhibiting the cancer cell migration by inhibiting the expression of ribose-5-phosphate isomerase A.

Abstract: Disclosed is a method for extending lifespan in a subject. By screening for mutations that enhance resistance to multiple stresses, the invention identified multiple alleles of alpha-1, 2-mannosidase I (mas1) which, in addition to promoting stress resistance, also extended longevity. Meanwhile, longevity enhancement of a subject is also observed when either the expression of mas1 or its downstream gene Edm1 is reduced. Furthermore, this invention also found that the down-regulating mas1 and Edm1 may extend longevity by modulating DR (Dietary Restriction). Thus, via molecular biology techniques, the expression of the target genes such as mas1 and Edm1 can be regulated, and the lifespan extension for a subject also can be achieved.