Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the cell membrane of cells can be introduced into cells by applying an alternating electric field to the cell for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the cell membrane. Once the permeability of the cell membrane has been increased, the substance is able to cross the cell membrane. This approach is particularly useful in the context of cancer cells (e.g., glioblastoma).

Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the cell membrane of cells can be introduced into cells by applying an alternating electric field to the cell for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the cell membrane. Once the permeability of the cell membrane has been increased, the substance is able to cross the cell membrane. This approach is particularly useful in the context of cancer cells (e.g., glioblastoma).

Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the cell membrane of cells can be introduced into cells by applying an alternating electric field to the cell for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the cell membrane. Once the permeability of the cell membrane has been increased, the substance is able to cross the cell membrane. This approach is particularly useful in the context of cancer cells (e.g., glioblastoma).

Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the cell membrane of cells can be introduced into cells by applying an alternating electric field to the cell for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the cell membrane. Once the permeability of the cell membrane has been increased, the substance is able to cross the cell membrane. This approach is particularly useful in the context of cancer cells (e.g., glioblastoma).

Abstract: A method for analyzing a three-dimensional stress concentrating feature of a component (60), such as a borehole (62), using a two-dimensional probabilistic technique. A circumferentially-dependent stress concentration profile around the stress concentrating feature is determined, and then a probability of failure of the component is calculated using a 2D probabilistic failure analysis of the stress concentration profile. The probabilistic failure analysis may include a Monte Carlo theta integration approach.

Abstract: A method for operating a machine component under stress. The method comprises determining a probability of failure PoF(N) of the component as a function of N cycles, selecting a time-based acceptable risk limit for the component and selecting an operational profile for the component, converting the time-based acceptable risk limit to a cycle-based acceptable risk limit using the operational profile, comparing the cycle-based acceptable risk limit with the PoF(N) values to determine an operational status of the component, comparing the cycle-based acceptable risk limit with the PoF(N) values, and operating the machine component responsive to results of the comparing step.

Abstract: A device to route cooling air to a turbine blade is provided. The device includes a seal ring having an L-shaped cross section configured to abut a turbine disc. The seal ring includes a radial portion extending radially with respect to a rotor and an axial portion extending axially with respect to the rotor. The seal ring also includes a plurality of radial cooling holes disposed within the radial portion of the seal ring and arranged circumferentially around the seal ring. The plurality of cooling holes route cooling air from a device configured to impart tangential momentum to the cooling air to a turbine blade in order to cool the turbine blade. A system and a method to improve a flow of rotor cooling air to a turbine blade are also provided.

Abstract: A method for operating a machine component under stress. The method comprises determining a probability of failure PoF(N) of the component as a function of N cycles, selecting a time-based acceptable risk limit for the component and selecting an operational profile for the component, converting the time-based acceptable risk limit to a cycle-based acceptable risk limit using the operational profile, comparing the cycle-based acceptable risk limit with the PoF(N) values to determine an operational status of the component, comparing the cycle-based acceptable risk limit with the PoF(N) values, and operating the machine component responsive to results of the comparing step.

Abstract: A method for analyzing a three-dimensional stress concentrating feature of a component (60), such as a borehole (62), using a two-dimensional probabilistic technique. A circumferentially-dependent stress concentration profile around the stress concentrating feature is determined, and then a probability of failure of the component is calculated using a 2D probabilistic failure analysis of the stress concentration profile. The probabilistic failure analysis may include a Monte Carlo theta integration approach.