Patents by Inventor Chirag B. Shah
Chirag B. Shah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6830583Abstract: Coatings are provided in which biopolymers may be covalently linked to a substrate. Such biopolymers include those that impart thromboresistance and/or biocompatibility to the substrate, which may be a medical device. Coatings disclosed herein include those that permit coating of a medical device in a single layer, including coatings that permit applying the single layer without a primer. Suitable biopolymers include heparin complexes, and linkage may be provided by a silane having isocyanate functionality.Type: GrantFiled: May 23, 2001Date of Patent: December 14, 2004Assignee: Medtronic Ave, Inc.Inventors: Chirag B Shah, Laurel L Wolfgang
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Publication number: 20040219180Abstract: The invention includes systems and methods for stimulating intramuscular angiogenesis by placing a biocompatible device within the tissue of a muscle. The biocompatible device is dimensionally adapted for placement within the tissue of a muscle. Placement of the biocompatible device within the muscle can take place according to the method of the invention by using techniques familiar to those of ordinary skill in the art. Illustrative techniques for placement of the device within the myocardium comprise one practice of the method of the invention.Type: ApplicationFiled: January 29, 2004Publication date: November 4, 2004Applicant: C. R. Bard, Inc.Inventors: Richard A. Gambale, Mike Weiser, Stephen Forcucci, Chirag B. Shah
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Publication number: 20040087996Abstract: The present invention provides a catheter positioning system which serves to control and stabilize a distal end of a catheter at a treatment site within a patient so that a medical procedure can be performed with accuracy. Generally, the positioning system operates by providing a deformable mechanical members at the distal end of the catheter which can be operated from the proximal end of the catheter to extend radially outward to engage surrounding tissue adjacent to treatment site. In one embodiment of the invention a flexible superstructure comprising the plurality of flexible veins extending longitudinally along the distal end of the catheter can be deformed to bow radially outward to engage surrounding tissue. The distal tip of the catheter joined to one of the veins was correspondingly displaced or rotated angularly as the veins bow outward.Type: ApplicationFiled: June 27, 2003Publication date: May 6, 2004Applicant: C. R. Bard, Inc.Inventors: Richard A. Gambale, Stephen J. Forcucci, Chirag B. Shah, Michael F. Weiser, Sean Forde
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Publication number: 20040043068Abstract: Methods are provided for delivering nitric oxide to the vascular tissue of a patient to inhibit or prevent restenosis or improve vascular function following various surgical procedures or associated with various NO-related conditions. The disclosed methods comprise contacting the vascular tissue of a patient with a medical device coated with a coating comprising nitric oxide associated with and releaseable from a polyurea network formed from the reaction on said medical device of a polyisocyanate; an amine donor and/or hydroxyl donor; an isocyanatosilane adduct having terminal isocyanate groups and at least one hydrolyzable alkoxy group bonded to silicon; and optionally a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid.Type: ApplicationFiled: September 4, 2003Publication date: March 4, 2004Inventors: Eugene Tedeschi, Chirag B. Shah
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Patent number: 6692520Abstract: The invention includes systems and methods for stimulating intramuscular angiogenesis by placing a biocompatible device within the tissue of a muscle. The biocompatible device is dimensionally adapted for placement within the tissue of a muscle. Placement of the biocompatible device within the muscle can take place according to the method of the invention by using techniques familiar to those of ordinary skill in the art. Illustrative techniques for placement of the device within the myocardium comprise one practice of the method of the invention.Type: GrantFiled: December 15, 1998Date of Patent: February 17, 2004Assignee: C. R. Bard, Inc.Inventors: Richard A. Gambale, Mike Weiser, Stephen Forcucci, Chirag B. Shah
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Patent number: 6645518Abstract: Methods are provided for delivering nitric oxide to the vascular tissue of a patient to inhibit or prevent restenosis or improve vascular function following various surgical procedures or associated with various NO-related conditions. The disclosed methods comprise contacting the vascular tissue of a patient with a medical device coated with a coating comprising nitric oxide associated with and releaseable from a polyurea network formed from the reaction on said medical device of a polyisocyanate; an amine donor and/or hydroxyl donor; an isocyanatosilane adduct having terminal isocyanate groups and at least one hydrolyzable alkoxy group bonded to silicon; and optionally a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid.Type: GrantFiled: April 30, 2002Date of Patent: November 11, 2003Inventors: Eugene Tedeschi, Chirag B. Shah
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Patent number: 6629987Abstract: The present invention provides a catheter positioning system which serves to control and stabilize a distal end of a catheter at a treatment site within a patient so that a medical procedure can be performed with accuracy. Generally, the positioning system operates by providing a deformable mechanical members at the distal end of the catheter which can be operated from the proximal end of the catheter to extend radially outward to engage surrounding tissue adjacent to treatment site. In one embodiment of the invention a flexible superstructure comprising the plurality of flexible veins extending longitudinally along the distal end of the catheter can be deformed to bow radially outward to engage surrounding tissue. The distal tip of the catheter joined to one of the veins was correspondingly displaced or rotated angularly as the veins bow outward.Type: GrantFiled: July 30, 1999Date of Patent: October 7, 2003Assignee: C. R. Bard, Inc.Inventors: Richard A. Gambale, Stephen J. Forcucci, Chirag B. Shah, Michael F. Weiser, Sean Forde
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Patent number: 6511507Abstract: A coating composition is provided comprising hyaluronic acid or a salt thereof and a blocked polyisocyanate in a solvent comprising water. A method is provided for preparing the coating on a substrate comprising forming a coating mixture of hyaluronic acid or a salt thereof and a blocked polyisocyanate in a solvent comprising water; applying the coating mixture to the substrate; and curing the coating.Type: GrantFiled: May 10, 2002Date of Patent: January 28, 2003Assignee: Medtronic AVE Inc.Inventors: Chirag B. Shah, John A. Hudson, Eugene Tedeschi
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Publication number: 20020127409Abstract: A coating composition is provided comprising hyaluronic acid or a salt thereof and a blocked polyisocyanate in a solvent comprising water. A method is provided for preparing the coating on a substrate comprising forming a coating mixture of hyaluronic acid or a salt thereof and a blocked polyisocyanate in a solvent comprising water; applying the coating mixture to the substrate; and curing the coating.Type: ApplicationFiled: May 10, 2002Publication date: September 12, 2002Inventors: Chirag B. Shah, John A. Hudson, Eugene Tedeschi
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Publication number: 20020122814Abstract: Methods are provided for delivering nitric oxide to the vascular tissue of a patient to inhibit or prevent restenosis or improve vascular function following various surgical procedures or associated with various NO-related conditions. The disclosed methods comprise contacting the vascular tissue of a patient with a medical device coated with a coating comprising nitric oxide associated with and releaseable from a polyurea network formed from the reaction on said medical device of a polyisocyanate; an amine donor and/or hydroxyl donor; an isocyanatosilane adduct having terminal isocyanate groups and at least one hydrolyzable alkoxy group bonded to silicon; and optionally a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid.Type: ApplicationFiled: April 30, 2002Publication date: September 5, 2002Inventors: Eugene Tedeschi, Chirag B. Shah
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Patent number: 6387450Abstract: A coating composition is provided comprising hyaluronic acid or a salt thereof and a blocked polyisocyanate in a solvent comprising water. A method is provided for preparing the coating on a substrate comprising forming a coating mixture of hyaluronic acid or a salt thereof and a blocked polyisocyanate in a solvent comprising water; applying the coating mixture to the substrate; and curing the coating.Type: GrantFiled: November 9, 2000Date of Patent: May 14, 2002Assignee: Medtronic AVE, Inc.Inventors: Chirag B. Shah, John A. Hudson, Eugene Tedeschi
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Patent number: 6379691Abstract: Methods are provided for delivering nitric oxide to the vascular tissue of a patient to inhibit or prevent restenosis or improve vascular function following various surgical procedures or associated with various NO-related conditions. The disclosed methods comprise contacting the vascular tissue of a patient with a medical device coated with a coating comprising nitric oxide associated with and releaseable from a polyurea network formed from the reaction on said medical device of a polyisocyanate; an amine donor and/or hydroxyl donor; an isocyanatosilane adduct having terminal isocyanate groups and at least one hydrolyzable alkoxy group bonded to silicon; and optionally a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid.Type: GrantFiled: November 30, 2000Date of Patent: April 30, 2002Assignee: Medtronic/AVE, Inc.Inventors: Eugene Tedeschi, Chirag B. Shah
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Patent number: 6361819Abstract: Coatings are provided in which biopolymers may be covalently linked to a substrate. Such biopolymers include those that impart thromboresistance and/or biocompatibility to the substrate, which may be a medical device. Coatings disclosed herein include those that permit coating of a medical device in a single layer, including coatings that permit applying the single layer without a primer. Suitable biopolymers include heparin complexes, and linkage may be provided by a silane having isocyanate functionality. Plasma deposition and solvent swelling techniques are described as preferred methods of depositing a derivatized silane or a silane-heparin coating.Type: GrantFiled: August 20, 1999Date of Patent: March 26, 2002Assignee: Medtronic AVE, Inc.Inventors: Eugene Tedeschi, Chirag B. Shah, Laurel L. Wolfgang
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Publication number: 20020022046Abstract: Methods are provided for delivering nitric oxide to the vascular tissue of a patient to inhibit or prevent restenosis or improve vascular function following various surgical procedures or associated with various NO-related conditions. The disclosed methods comprise contacting the vascular tissue of a patient with a medical device coated with a coating comprising nitric oxide associated with and releaseable from a polyurea network formed from the reaction on said medical device of a polyisocyanate; an amine donor and/or hydroxyl donor; an isocyanatosilane adduct having terminal isocyanate groups and at least one hydrolyzable alkoxy group bonded to silicon; and optionally a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid.Type: ApplicationFiled: November 30, 2000Publication date: February 21, 2002Applicant: Arterial Vascular Engineering, Inc.Inventors: Eugene Tedeschi, Chirag B. Shah
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Publication number: 20010034336Abstract: Coatings are provided in which biopolymers may be covalently linked to a substrate. Such biopolymers include those that impart thromboresistance and/or biocompatibility to the substrate, which may be a medical device. Coatings disclosed herein include those that permit coating of a medical device in a single layer, including coatings that permit applying the single layer without a primer. Suitable biopolymers include heparin complexes, and linkage may be provided by a silane having isocyanate functionality.Type: ApplicationFiled: May 23, 2001Publication date: October 25, 2001Inventors: Chirag B. Shah, Laurel L. Wolfgang
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Patent number: 6299980Abstract: A coating is provided comprising a polyurethane network formed from the reaction on a substrate to be coated, of a mixture comprising a polyisocyanate; a hydroxyl donor and/or amine donor; a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid; and an isocyanatosilane adduct having terminal isocyanate groups and at least one hydrolyzable alkoxy group bonded to silicon in a solvent. A method for preparing the coating is also provided.Type: GrantFiled: September 29, 1998Date of Patent: October 9, 2001Assignee: Medtronic AVE, Inc.Inventors: Chirag B. Shah, Eugene Tedeschi
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Patent number: 6280414Abstract: The present invention provides a device and method for delivering a therapeutic substance to a treatment site within a patient such as a vessel that has undergone angioplasty. The device provides flexible conduits placed together in the vessel along with a shaft that is attached to their distal ends. After being navigated to the treatment site, the shaft may be moved relative to the conduits causing them to buckle and bow radially outward into contact with the tissue to be treated. The therapeutic substance is then pressurized to be delivered through perfusion ports along the distal portion of the conduits. Because the conduits can be expanded into contact with the treatment site without the assistance of an inflatable member, blood flow through the region during delivery of the therapeutic substance is not interrupted in any significant way. Alternatively, the present invention may be used in conjunction with a balloon angioplasty catheter to deliver therapeutic substances after the dilatation procedure.Type: GrantFiled: September 30, 1998Date of Patent: August 28, 2001Assignee: Medtronic AVE, Inc.Inventors: Chirag B. Shah, Richard A. Gambale, Stephen J. Forcucci
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Patent number: 6248127Abstract: Coatings are provided in which biopolymers may be covalently linked to a substrate. Such biopolymers include those that impart thromboresistance and/or biocompatibility to the substrate, which may be a medical device. Coatings disclosed herein include those that permit coating of a medical device in a single layer, including coatings that permit applying the single layer without a primer. Suitable biopolymers include heparin complexes, and linkage may be provided by a silane having isocyanate functionality.Type: GrantFiled: August 21, 1998Date of Patent: June 19, 2001Assignee: Medtronic AVE, Inc.Inventors: Chirag B. Shah, Laurel L Wolfgang
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Patent number: 6218016Abstract: A coating is provided for a substrate comprising a polyisocyanate; an amine donor and/or hydroxyl donor; an isocyanatosilane adduct having terminal isocyanate groups and at least one hydrolyzable alkoxy group bonded to silicon; and optionally a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid. The coating can accommodate a drug so that when the coating is applied to a medical device, the medical device becomes drug-releasing when in contact with aqueous body fluid. A coated article as well as a method for preparing the coating is also provided.Type: GrantFiled: September 27, 1999Date of Patent: April 17, 2001Assignee: Medtronic AVE, Inc.Inventors: Eugene Tedeschi, Chirag B. Shah
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Patent number: RE39438Abstract: Coatings are provided in which biopolymers may be covalently linked to a substrate. Such biopolymers include those that impart thromboresistance and/or biocompatibility to the substrate, which may be a medical device. Coatings disclosed herein include those that permit coating of a medical device in a single layer, including coatings that permit applying the single layer without a primer. Suitable biopolymers include heparin complexes, and linkage may be provided by a silane having isocyanate functionality.Type: GrantFiled: October 7, 2003Date of Patent: December 19, 2006Assignee: Medtronic Vascular, Inc.Inventors: Chirag B Shah, Laurel L Wolfgang