Abstract: The invention provides an ocular composition comprising: 99 to 60% (w/w) of a photopolymerizable composition selected from the group of fragments or monomers consisting of polyalkylene glycol diacrylate and polyalkylene glycol dimethacrylate, wherein the photopolymerizable composition has a molecular weight in the range of 100 to 20,000 Dalton; a biodegradable polymer selected from the group consisting of aliphatic polyester-based polyurethanes, polylactides, polycaprolactones, polyorthoesters and mixtures, copolymers, and block copolymers thereof; a photoinitiator; and a therapeutic agent. The composition can be used to form an ocular implant and an in situ ocular implant.

Abstract: A composite implant for sustained release of a therapeutic agent in an ocular area of a subject. The composite implant comprises a matrix of photopolymerized polymer formed from a photopolymerizable composition, a biodegradable polymer contained within the matrix, and a therapeutic agent dispersed or dissolved between the matrix and/or biodegradable polymer, wherein the implant is formed from an ocular composition comprising 99 to 60% (w/w) of the photopolymerizable composition. The composite implant can be used in methods of delivering a therapeutic agent to an ocular area in a subject in need thereof, particularly by injecting the implant into the ocular area. Methods of preparing the composite implant are also disclosed.

Abstract: The invention provides an ocular composition comprising: 99 to 60% (w/w) of a photopolymerizable composition selected from the group of fragments or monomers consisting of polyalkylene glycol diacrylate and polyalkylene glycol dimethacrylate, wherein the photopolymerizable composition has a molecular weight in the range of 100 to 20,000 Dalton; a biodegradable polymer selected from the group consisting of aliphatic polyester-based polyurethanes, polylactides, polycaprolactones, polyorthoesters and mixtures, copolymers, and block copolymers thereof; a photoinitiator; and a therapeutic agent. The composition can be used to form an ocular implant and an in situ ocular implant.