Patents by Inventor Chisa Aoki

Chisa Aoki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cultured silkworm cells capable of highly efficient baculovirus production and protein production
    Patent number: 7955793
    Abstract: Known cell lines derived from silkworm exhibit low propagation efficiency of BmNPV. Accordingly, systems using known culture cell lines derived from silkworms take a long time to establish recombinant viruses, and are not suitable for preparation of virus solutions with high titers. The present invention provides a cell line Bme21 (FERM P-20852) that is derived from a silkworm embryo and is highly susceptible to BmNPV or its variant having the same biological characteristics. The present invention also provides a method of producing a recombinant virus, a method of producing a recombinant protein, a method of increasing efficiency of recombinant virus production, and a method of increasing efficiency of recombinant protein production, using the cell line Bme21 or its variant.
    Type: Grant
    Filed: April 26, 2007
    Date of Patent: June 7, 2011
    Assignee: Kyushu University, National University Corporation
    Inventors: Takahiro Kusakabe, Chisa Aoki, Osamu Ninagi, Jae Man Lee, Kazuhiro Iiyama, Naoya Kawakami
  • Novel Cultured Silkworm Cells Capable of Highly Efficient Baculovirus Production and Protein Production
    Publication number: 20090305385
    Abstract: Known cell lines derived from silkworm exhibit low propagation efficiency of BmNPV. Accordingly, systems using known culture cell lines derived from silkworms take a long time to establish recombinant viruses, and are not suitable for preparation of virus solutions with high titers. The present invention provides a cell line Bme21 (FERM P-20852) that is derived from a silkworm embryo and is highly susceptible to BmNPV or its variant having the same biological characteristics. The present invention also provides a method of producing a recombinant virus, a method of producing a recombinant protein, a method of increasing efficiency of recombinant virus production, and a method of increasing efficiency of recombinant protein production, using the cell line Bme21 or its variant.
    Type: Application
    Filed: April 26, 2007
    Publication date: December 10, 2009
    Applicant: Kyushu University, National University Corporation
    Inventors: Takahiro Kusakabe, Chisa Aoki, Osamu Ninagi, Jae Man Lee, Kazuhiro Iiyama, Naoya Kawakami