Patents by Inventor Chisei Ra

Chisei Ra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transcriptional regulation of high affinity IgE receptor ?-chain
    Patent number: 8058231
    Abstract: Transcriptional regulatory regions and transcriptional regulatory factors for the human high affinity IgE receptor (Fc?RI) ?-chain gene are specified and are targets for the development of transcriptional regulatory agents for the Fc?RI ?-chain gene. The following are provided: DNA comprising the full length or a portion of the base sequence shown in SEQ ID NO:1, that regulates transcription of the human high affinity IgE receptor (Fc?RI) ?-chain gene; and DNA comprising the full length or a portion of the base sequence shown in SEQ ID NO:2, that regulates transcription of the human high affinity IgE receptor (Fc?RI) ?-chain gene. The present invention is promising for the development of novel agents for the prophylaxis/treatment of allergic diseases, autoimmune diseases, thrombosis, glomerulonephritis, and lupus nephritis.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: November 15, 2011
    Assignee: Nihon University
    Inventors: Chisei Ra, Kyoko Takahashi
  • Regulation of expression of high-affinity immunoglobulin E (IgE) receptor ?-chain
    Patent number: 7550577
    Abstract: The present invention provides a polynucleotide comprising all or a part of the nucleotide sequence identified as SEQ ID NO:1 that regulates transcription of the human high-affinity IgE receptor (Fc?FI) ?-chain gene, and a method for regulating transcription of the Fc?FI ?-chain gene which comprises the step of promoting binding between a transcription regulatory complex containing MZF-1 and the transcription regulatory region of the Fc?FI ?-chain gene that contains the nucleotide sequence identified as SEQ ID NO: 1. In addition, the present invention provides a screening method and a kit therefor that utilizes the method for regulating transcription of the Fc?FI ?-chain gene having the step of promoting binding between a transcription regulatory complex containing MZF-1 and the transcription regulatory region of the Fc?FI ?-chain gene that contains the nucleotide sequence identified as SEQ ID NO:1, thereby enabling development of a novel agent for the prevention and treatment of allergic diseases.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: June 23, 2009
    Assignee: Nihon University
    Inventors: Chisei Ra, Kyoko Takahashi
  • Transcriptional Regulation of High Affitnity Ige Receptor Gamma-Chain
    Publication number: 20090054324
    Abstract: Transcriptional regulatory regions and transcriptional regulatory factors for the human high affinity IgE receptor (Fc?RI) ?-chain gene are specified and are targets for the development of transcriptional regulatory agents for the Fc?RI ?-chain gene. The following are provided: DNA comprising the full length or a portion of the base sequence shown in SEQ ID NO:1, that regulates transcription of the human high affinity IgE receptor (Fc?RI) ?-chain gene; and DNA comprising the full length or a portion of the base sequence shown in SEQ ID NO:2, that regulates transcription of the human high affinity IgE receptor (Fc?RI) ?-chain gene. The present invention is promising for the development of novel agents for the prophylaxis/treatment of allergic diseases, autoimmune diseases, thrombosis, glomerulonephritis, and lupus nephritis.
    Type: Application
    Filed: September 20, 2006
    Publication date: February 26, 2009
    Inventors: Chisei Ra, Kyoko Takahashi
  • Regulation of expression of high-affinity immunoglobulin e (ige) receptor beta-chain
    Publication number: 20070081990
    Abstract: The present invention provides a polynucleotide comprising all or a part of the nucleotide sequence identified as SEQ ID NO:1 that regulates transcription of the human high-affinity IgE receptor (Fc?Rl) ?-chain gene, and a method for regulating transcription of the Fc?Rl ?-chain gene which comprises the step of promoting binding between a transcription regulatory complex containing MZF-1 and the transcription regulatory region of the Fc?Rl ?-chain gene that contains the nucleotide sequence identified as SEQ ID NO: 1. In addition, the present invention provides a screening method and a kit therefor that utilizes the method for regulating transcription of the Fc?Rl ?-chain gene having the step of promoting binding between a transcription regulatory complex containing MZF-1 and the transcription regulatory region of the Fc?Rl ?-chain gene that contains the nucleotide sequence identified as SEQ ID NO:1, thereby enabling development of a novel agent for the prevention and treatment of allergic diseases.
    Type: Application
    Filed: June 4, 2003
    Publication date: April 12, 2007
    Inventors: Chisei Ra, Kyoko Takahashi
  • Antiallergic compostion
    Patent number: 6090384
    Abstract: Disclosed is an antiallergic composition comprising, as an active ingredient, a peptide which is capable of binding to human IgE, more specifically the high-affinity immunoglobulin E receptor .alpha. chain or a soluble fragment, which is capable of binding to human IgE, or the high-affinity immunoglobulin E receptor .alpha. chain. The composition is clinically useful for blocking allergic responses.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: July 18, 2000
    Assignees: Chisei RA, Yoshitomi Pharmaceuticals Industries, Ltd.
    Inventors: Chisei Ra, Koji Naito, Minoru Hirama, Ko Okumura
  • Immunoglobulin E receptor .alpha.-chain inhibits IgE production and secondary allergic responses
    Patent number: 5874404
    Abstract: Disclosed is an antiallergic composition comprising, as an active ingredient, a peptide which is capable of binding to human IgE, more specifically the high-affinity immunoglobulin E receptor .alpha.-chain or a soluble fragment, which is capable of binding to human IgE, or the high-affinity immunoglobulin E receptor .alpha.-chain. The composition is clinically useful for blocking allergic responses. An animal model for use in the screening of prophylactic and therapeutic compositions for IgE-related diseases is also disclosed.
    Type: Grant
    Filed: May 3, 1994
    Date of Patent: February 23, 1999
    Assignees: Chisei Ra, The Green Cross Corporation
    Inventors: Chisei Ra, Koji Naito, Minoru Hirama, Ko Okumura, Yukiyoshi Yanagihara