Abstract: The present invention provides a topical formulation containing NSAID, particularly diclofenac. The topical formulation is particularly useful for alleviating pain/inflammation associated with infection caused by herpes virus, especially herpes simplex virus (HSV) and varicella-zoster virus (VZV). Similar relief can be achieved where diclofenac is replaced with another non-steroidal anti-inflammatory drug (NSAID), which includes, without limitation, etodolac, ketorolac, bromfenac, diflunisal, ibuprofen, fenoprofen, ketoprofen, naproxen, suprofen, meclofenamate, mefenamic acid, piroxicam, meloxicam, indomethacin, sulindac, phenylbutazone, oxyphenbutazone, and tolmetin. The topical formulation is further characterized by its fast relief on pain and/or inflammation associated with infection caused by herpes virus, i.e., a complete relief in no more than seven (7) days after the application of the topical formulation on skins of patients.

Abstract: An improved structure of a hand-saw having adjustable sawing blade includes two holding sections, a front and a rear holding section, a sawing blade, a front-mounted ratchet teeth fine tuning block having one end with four teeth ratchet, the other end thereof being a semicircular and having a protruded cylindrical bar for the insertion of the sawing blade, a ratchet teeth adjusting sleeve being cylindrical shape having one end with inner edge being ratchet teeth shape, and the other end thereof being a larger internal radius, a rear-mounted ratchet wheel fine tuning block having an external edge with four ratchet teeth for engagement with the ratchet-teeth adjusting sleeve for the insertion of the other end of the sawing blade, a hexagonal pull-push engaging connector module having a circular shape center and a cavity adaptable to a hexagonal shape screw nut, a loosening button located at the root section of the rear holding section being an arch-shaped body and having a gripping section provided with a reces

Abstract: An improved structure of a hand-saw having adjustable sawing blade includes two holding sections, a front and a rear holding section, a sawing blade, a front-mounted ratchet teeth fine tuning block having one end with four teeth ratchet, the other end there of being a semicircular and having a protruded cylindrical bar for the insertion of the sawing blade, a ratchet teeth adjusting sleeve being cylindrical shape having one end with inner edge being ratchet teeth shape, and the other end thereof being a larger internal radius, a rear-mounted ratchet wheel fine tuning block having an external edge with four ratchet teeth for engagement with the ratchet-teeth adjusting sleeve for the insertion of the other end of the sawing blade, a hexagonal pull-push engaging connector module having a circular shape center and a cavity adaptable to a hexagonal shape screw nut, a loosening button located at the root section of the rear holding section being an arch-shaped body and having a gripping section provided with a rece

Abstract: The present invention provides pharmaceutically acceptable salts having local anesthetic and anti-inflammatory activities. The preferred pharmaceutically acceptable salt is a diclofenac salt of lidocaine. Diclofenac is a non-steroidal anti-inflammatory drug (“NSAID”). Lidocaine is a local anesthetic. Other NSAID (except the salicylic acid derivatives of NSAID) can be used to replace diclofenac and/or other local anesthetics can be used to replace lidocaine. The pharmaceutically acceptable salts are crystalline compounds, which are distinctively different from either the NSAID alone or the local anesthetic alone, as indicated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), High Performance Liquid Chromatography (HPLC) and Fourier-Transformed Infrared Spectroscopy (FTIR) analyses.

Abstract: The present invention provides oral pharmaceutical compositions for acetic acid class of non-steroidal anti-inflammatory drug (NSAID), particularly ketorolac. The pharmaceutical composition contains a core, a drug layer (which comprises the drug, a binder, and a disintegrant), a protecting layer, and an enteric coating layer. The oral pharmaceutical compositons are particularly useful for treating patients with moderate to acute pain. The present invention also provides a method for making the pharmaceutical compositions and a method for using the pharmaceutical compositions.

Abstract: The present invention provides novel pharmaceutical compositions for azole antimicrobial drugs such as itraconazole, saperconazole, ketoconazole, and fluconazole. The pharmaceutical compositions are in the form of pellets which comprise a core and a drug emulsion layer, and optionally, a protective layer. The drug emulsion layer contains the azole antimicrobial drug, an emulsifier, a binder, and an absorbent aid. The preferred emulsifier is vitamin E polyethylene glycol succinate. The preferred binder is hydroxypropyl methylcellulose. The preferred absorbent aid is DL malic acid. The drug is dissolved in organic solvents. The preferred organic solvents are ethanol and methylene chloride. The protective layer contains polyethylene glycol (PEG) 20,000, which is coated on the drug emulsion layer.

Abstract: The present invention provides a stable pharmaceutical composition which contains an acetic acid class of non-steroidal anti-inflammatory drug (NSAID), a phosphate solution, an isotonic agent, and water. The pharmaceutical composition is particularly suitable for parenteral injection such as intravenous or intramuscular injection. The preferred NSAID is ketorolac tromethamine, which includes any racemic mixture of [−]S and [+]R ketorolac tromethamine. The preferred phosphate solution contains sodium phosphate monobasic (NaH2PO4) or potassium phosphate monobasic (KH2PO4), with or without crystalline water. The preferred isotonic agent is NaCl. The pharmaceutical composition is preferably at pH 6.0 to 8.5 and with osmolarity within 0.5 to 3.

Abstract: An improved structure of a penknife is disclosed.

Abstract: A structure of multi-directional, combination-type ratchet wheel wrench with sleeve is disclosed.

Abstract: The present invention provides novel pharmaceutical compositions for azole antimicrobial drugs such as itraconazole, saperconazole, ketoconazole, and fluconazole. The pharmaceutical compositions are in the form of pellets which comprise a core and a drug emulsion layer, and optionally, a protective layer. The drug emulsion layer contains the azole antimicrobial drug, an emulsifier, a binder, and an absorbent aid. The preferred emulsifier is vitamin E polyethylene glycol succinate. The preferred binder is hydroxypropyl methylcellulose. The preferred absorbent aid is DL malic acid. The drug is dissolved in organic solvents. The preferred organic solvents are ethanol and methylene chloride. The protective layer contains polyethylene glycol (PEG) 20,000, which is coated on the drug emulsion layer.

Abstract: A wheel rack improvement of a trolley suitcase includes a pair of corner seats and a central seat secured to the lower portion of the suitcase. The corner seats each has a main prop and subordinate prop rotatably secured therein and overlapped each other. The central seat has a footboard rotatably secured by a link and a rotor, a pair of axial pipes spacedly secured to the back of the central seat each including a male pipe and a female pipe axially sleeve with each other. An insertion rod engageable with a positioning hole of the subordinate prop biased by a spring. A steel wire has a first enlarged head retained in a slot of the insertion rod and a second enlarged head retained in a slot of the rotor for controlling the insertion rod the engage or disengage with the positioning hole of the subordinate prop. Therefore, the props may separate with each other to make a four wheels touching the ground.

Abstract: Representing display objects, such as windows, in a graphical user interface in such a way as to indicate which display object should be focused on by a user as a currently active display object. The method includes modifying appearance characteristics of a first display object, the first display object transitioning from an active to an inactive state, to make the first display object appear farther from a user than at least one other display object. The method further includes modifying appearance characteristics of a second display object, the second display object transitioning from the inactive state to the active state, to make the second display object appear closer to the user than at least the first display object. The user intuitively recognizes the nearer display object as the currently active display object.

Abstract: A collapsible handle for a portable luggage is provided. The handle includes an upper seat and a lower seat spacedly secured to the top and lower portions of the back side of the portable luggage, an attachment slidably pivoted to a pair of rectangular recesses of the upper seat, an elongate caster seat including a pair of subordinate casters pivoted on two end which has an arcuate lower surface made engageable with a concaved engaging surface in the top of the lower seat, a pair of telescoped frame having their upper ends inserting through the attachment and secured to a handle grip above the attachment and their lower ends of the outmost portion secured to a pair of cavities at two end of the elongate caster seat and the inner portion respectively biased by a pair of post of a locking member which is in turn biased by a pair of springs inside the elongate caster seat.

Abstract: The present invention provides pharmaceutical formulations which contain (a) an inert core of sugar, sugar and starch, or microcrystalline cellulose, (b) a drug emulsion layer which is made from mixing a free base of benzimidazole derivative (such as omeprazole or lansoprazole) with a nonionic surfactant and water, (c) a protective coating which is made of a film-forming compound, and optionally a plasticizer or excipient, and (d) an enteric coating which is made of a pharmaceutically acceptable polymer and a plasticizer. Optionally, a basic amino acid can be added to the drug emulsion layer or the protective coating. The present invention also provides the method for making the pharmaceutical formulations.

Abstract: The present invention relates to a fast-release as well as a prolonged release type of nifedipine pellets and the process for the preparation thereof. The fast-release type of nifedipine pellets comprises a particulate core which is covered by a nifedipine coating layer. The particulate core comprises water-soluble or water-insoluble excipient(s) and a pharmacologically acceptable carrier. The nifedipine coating layer comprises an effective amount of nifedipine dissolved in organic solvent(s). This nifedipine coating layer can further be mixed with a suspension which comprises an adhesive, an emulsifier, and a dispersant. The preferred composition of the fast-release type of nifedipine includes 20-70% of the particulate core, 3-15% of nifedipine, 1-20% of emulsifier, 1-20% of adhesive, and 1-30% of dispersant.

Abstract: A screw driver includes a hand grip having a driving stem extended forward from the hand grip, and a slide slidably engaged in the hand grip and rotated in concert with the hand grip. A handle is pivotally coupled to the slide at a pivot shaft for allowing the handle to be rotated relative to the slide and the hand grip to a perpendicular position relative to the hand grip and for allowing the hand grip and the driving stem to be rotated by the handle via the slide. The handle may include a retractable pole slidably engaged in a tube which is pivotally coupled to the slide.

Abstract: A ratchet tool includes a housing having a pair of protrusions oppositely extended inward of a chamber for forming two pairs of parallel channels. A gear is rotatably received in the chamber of the housing and has a driving shaft extended outward of the housing. Two pairs of pawls are slidably engaged in the channels and biased to engage with the gear for allowing the housing to drive the gear. The gear may be selectively driven in an active direction or in a reverse direction when one pair or the other pair of the pawls are disengaged from the gear.

Abstract: A ratchet tool includes a housing having an oval inner peripheral surface, and a core rotatably engaged in the housing for forming two curved slots between the housing and the core. The curved slots each includes two narrower end portions and a wider middle portion. Two pairs of wedges are slidably engaged in the curved slots and are biased to engage with the narrower ends for allowing the housing to drive the core. The wedges may be selectively moved toward the wider middle portions for allowing the housing to be rotated relative to the core in a reverse direction.

Abstract: An adjustable wrench includes a head formed on one end of a tube and having an opening for slidably receiving an engaging member. The tube has a bore communicating with the opening for rotatably and slidably receiving a rod. The rod is threadedly engaged with the head for moving the engaging member toward and away from the tube for allowing the engaging member to engage with fasteners of different sizes. A handle is secured to the rod for rotating the rod and for moving the engaging member toward and away from the fastener.