Patents by Inventor Chiung-Mei CHEN

Chiung-Mei CHEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHETIC COMPOUND, KIT COMPRISING THE SAME, AND USES THEREOF
    Publication number: 20240409570
    Abstract: Disclosed herein is a compound and its use for the prognosis or diagnosis of neurodegenerative diseases. The compound has the structure of formula (I), According to embodiments of the present disclosure, the neurodegenerative disease may be an Alzheimer's disease (AD), Parkinson disease (PD), Huntington's disease (HD), frontotemporal dementia (FTD), Friedreich's ataxia, age-related macular degeneration, or Creutzfeldt-Jakob disease.
    Type: Application
    Filed: September 8, 2022
    Publication date: December 12, 2024
    Inventors: Yun-Ru CHEN, Chung-Yi WU, Hwai-I YANG, Chiung-Mei CHEN, Pei-Ning WANG
  • Method for treating spinocerebellar ataxias
    Patent number: 10213470
    Abstract: The present invention relates to a method for treating spinocerebellar ataxias comprising administering a pharmaceutical composition comprising of therapeutically effective amounts of Paeonia lactiflora and Glycyrrhiza uralensis to a subject in need. The pharmaceutical composition reduces productions of reactive oxygen species and inflammatory factors to suppress polyglutamine aggregation.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: February 26, 2019
    Assignee: NATIONAL TAIWAN NORMAL UNIVERSITY
    Inventors: Guey-Jen Lee-Chen, Chiung-Mei Chen
  • Method for inhibiting neuronal cell aggregation
    Patent number: 9770478
    Abstract: The invention relates to a novel use of the Chinese herb Glycyrrhiza inflata in treatment of neurodegenerative disorders. Particularly, the invention relates to the use of ammonium glycyrrhizinate and licochalcone A in targeting polyQ-mediated spinocerebellar ataxia.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: September 26, 2017
    Assignee: NATIONAL TAIWAN NORMAL UNIVERSITY
    Inventors: Guey-Jen Lee-Chen, Chiung-Mei Chen
  • METHOD FOR TREATING SPINOCEREBELLAR ATAXIAS
    Publication number: 20170000835
    Abstract: The present invention relates to a method for treating spinocerebellar ataxias comprising administering a pharmaceutical composition comprising of therapeutically effective amounts of Paeonia lactiflora and Glycyrrhiza uralensis to a subject in need. The pharmaceutical composition reduces productions of reactive oxygen species and inflammatory factors to suppress polyglutamine aggregation.
    Type: Application
    Filed: January 15, 2016
    Publication date: January 5, 2017
    Inventors: Guey-Jen LEE-CHEN, Chiung-Mei CHEN
  • METHOD FOR INHIBITING NEURONAL CELL AGGREGATION
    Publication number: 20150190444
    Abstract: The invention relates to a novel use of the Chinese herb Glycyrrhiza inflata in treatment of neurodegenerative disorders. Particularly, the invention relates to the use of ammonium glycyrrhizinate and licochalcone A in targeting polyQ-mediated spinocerebellar ataxia.
    Type: Application
    Filed: December 30, 2014
    Publication date: July 9, 2015
    Inventors: Guey-Jen LEE-CHEN, Chiung-Mei CHEN
  • METHOD FOR TREATING ABNORMAL POLYGLUTAMINE-MEDIATED DISEASES
    Publication number: 20150064287
    Abstract: The present invention relates to a method for treating abnormal polyglutamine-mediated diseases comprising: administering a pharmaceutical composition comprising one or more selected from the group consisting of a Gardenia jasminoides extract, geniposide and crocin.
    Type: Application
    Filed: August 19, 2014
    Publication date: March 5, 2015
    Inventors: Guey-Jen LEE-CHEN, Chiung Mei CHEN
  • Method for Inhibiting Spinocerebellar Ataxia
    Publication number: 20140249095
    Abstract: A method for inhibiting spinocerebellar ataxia is disclosed, which comprises: administering an extract of Paeonia lactiflora to a subject in need; wherein a concentration of the extract of Paeonia lactiflora is in the range from 1 ?g/mL to 80 ?g/mL.
    Type: Application
    Filed: February 28, 2014
    Publication date: September 4, 2014
    Applicant: National Normal University
    Inventors: Guey-Jen LEE-CHEN, Chiung-Mei CHEN
  • Biomarker and method for evaluating risk for Parkinson's disease
    Publication number: 20130345074
    Abstract: A biomarker and a method for evaluating a risk for Parkinson's disease are disclosed. The method comprises: obtaining a sample from a tester, analyzing the polymorphic biomarker of the sample, wherein the biomarker is substrate-specifying subunit of SCF E3 ubiquitin ligase complex-FBXO7 gene; and when the cDNA sequence in position 155 of the biomarker is G or the amino acid sequence in position 52 of the biomarker is cysteine, it represents that the tester has a lower risk for Parkinson's disease.
    Type: Application
    Filed: March 14, 2013
    Publication date: December 26, 2013
    Inventors: Guey-Jen LEE-CHEN, Chiung-Mei CHEN, Yih-Ru WU