Patents by Inventor Chizuru Ito

Chizuru Ito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of identifying compounds that inhibit fertilization
    Patent number: 8741583
    Abstract: A method of identifying compounds that inhibit fertilization is provided. The method can include selecting compounds that bind to equatorin protein. Two types of equatorin protein, a long form and a short form, can be present in the testis. The amino acid sequence of mouse equatorin from positions 101 to 146 including the 138th O-glycosylated threonine residue contains an epitope recognized by anti-equatorin antibody MN9 that has an effect of inhibiting fertilization. In addition, the MN9 antibody also binds to human sperm. Compounds that bind to the epitope can inhibit fertilization. Both forms of mouse equatorin can be used as well as human equatorin to identify compounds that inhibit fertilization.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: June 3, 2014
    Assignee: National University Corporation Chiba University
    Inventors: Kiyotaka Toshimori, Chizuru Ito, Kenji Yamatoya, Keiichi Yoshida
  • Method Of Identifying Compounds That Inhibit Fertilization
    Publication number: 20120122244
    Abstract: A method of identifying compounds that inhibit fertilization is provided. The method can include selecting compounds that bind to equatorin protein. Two types of equatorin protein, a long form and a short form, can be present in the testis. The amino acid sequence of mouse equatorin from positions 101 to 146 including the 138th O-glycosylated threonine residue contains an epitope recognized by anti-equatorin antibody MN9 that has an effect of inhibiting fertilization. In addition, the MN9 antibody also binds to human sperm. Compounds that bind to the epitope can inhibit fertilization. Both forms of mouse equatorin can be used as well as human equatorin to identify compounds that inhibit fertilization.
    Type: Application
    Filed: March 31, 2010
    Publication date: May 17, 2012
    Applicant: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Kiyotaka Toshimori, Chizuru Ito, Kenji Yamatoya, Keiichi Yoshida