Patents by Inventor Chizuru Morikawa
Chizuru Morikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190353674Abstract: Provided is a method of accurately and easily determining a cause of the prolongation of blood coagulation time.Type: ApplicationFiled: August 1, 2019Publication date: November 21, 2019Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Remi Nakamura, Chizuru Morikawa, Hiroyuki Sunaga, Hirokazu Yago
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Patent number: 9977038Abstract: Provided is the development of a convenient LA detection method in which even a sample derived from a patient who receives anticoagulant therapy of warfarin, heparin or the like, is not affected by the anticoagulant therapy, discrimination from the deficiency of blood coagulation factors is enabled, and healthy person's plasma is not used. The method for detecting lupus anticoagulant includes the following steps (A), (B) and (C): (A) a step of adding a buffer solution composition containing blood coagulation factors to each of a blood sample and a diluted sample of the blood sample before measurement or at the time of measurement of the blood coagulation time; (B) a step of measuring the blood coagulation times for the various samples of step (A); and (C) a step of comparing the blood coagulation times for the various samples obtained in step (B).Type: GrantFiled: June 15, 2012Date of Patent: May 22, 2018Assignees: SCHOOL JURIDICAL PERSON HIGASHI-NIPPON-GAKUEN, SEKISUI MEDICAL CO., LTD.Inventors: Masahiro Ieko, Chizuru Morikawa
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Patent number: 9970046Abstract: Provided is a method of measuring blood coagulation time, the method being capable of LA detection easily and with high sensitivity as compared with the method recommended by the ISTH, without being affected by deficiency of blood coagulation factors even in a blood sample of a warfarin taker, a person who suffers from vitamin K deficiency, or a hepatic failure patient. Disclosed is a method of measuring the blood coagulation time to detect lupus anticoagulant, the method including adding a buffer solution composition containing blood coagulation factors to a blood sample before measurement or at the time of measurement of the blood coagulation time, and measuring the blood coagulation time.Type: GrantFiled: June 15, 2012Date of Patent: May 15, 2018Assignees: SCHOOL JURIDICAL PERSON HIGASHI-NIPPON-GAKUEN, SEKISUI MEDICAL CO., LTD.Inventors: Masahiro Ieko, Chizuru Morikawa, Keiko Hattori
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Patent number: 9733262Abstract: A method for measuring blood coagulation, including: preparing a reaction solution including a plasma specimen, a blood coagulation activator, and at least one of amino-guanidine and an acid addition salt thereof; and measuring blood coagulation time by detecting a turbidity change in the reaction solution.Type: GrantFiled: March 16, 2015Date of Patent: August 15, 2017Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Chizuru Morikawa, Remi Nakamura, Mitsuaki Yamamoto
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Publication number: 20150185236Abstract: Provided is a reagent, which prolongs a blood coagulation time sufficiently and enhances an optical change, thereby enabling a correct and high-sensitive blood coagulability test. The present invention provides a blood coagulation time prolonging agent, including, as an active ingredient, a guanidine compound represented by the following formula (1) or an acid addition salt thereof (in the formula, R1 represents a hydrogen atom, an amino group, or an alkyl group which may have a substituent).Type: ApplicationFiled: March 16, 2015Publication date: July 2, 2015Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Chizuru MORIKAWA, Remi NAKAMURA, Mitsuaki YAMAMOTO
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Publication number: 20150111235Abstract: Provided is a method of accurately and easily determining a cause of the prolongation of blood coagulation time.Type: ApplicationFiled: December 22, 2014Publication date: April 23, 2015Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Remi NAKAMURA, Chizuru Morikawa, Hiroyuki Sunaga, Hirokazu Yago
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Publication number: 20140127727Abstract: Provided is a reagent, which prolongs a blood coagulation time sufficiently and enhances an optical change, thereby enabling a correct and high-sensitive blood coagulability test. The present invention provides a blood coagulation time prolonging agent, including, as an active ingredient, a guanidine compound represented by the following formula (1) or an acid addition salt thereof (in the formula, R1 represents a hydrogen atom, an amino group, or an alkyl group which may have a substituent).Type: ApplicationFiled: January 13, 2014Publication date: May 8, 2014Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Chizuru MORIKAWA, Remi NAKAMURA, Mitsuaki YAMAMOTO
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Publication number: 20140127725Abstract: Provided is the development of a convenient LA detection method in which even a sample derived from a patient who receives anticoagulant therapy of warfarin, heparin or the like, is not affected by the anticoagulant therapy, discrimination from the deficiency of blood coagulation factors is enabled, and healthy person's plasma is not used. The method for detecting lupus anticoagulant includes the following steps (A), (B) and (C): (A) a step of adding a buffer solution composition containing blood coagulation factors to each of a blood sample and a diluted sample of the blood sample before measurement or at the time of measurement of the blood coagulation time; (B) a step of measuring the blood coagulation times for the various samples of step (A); and (C) a step of comparing the blood coagulation times for the various samples obtained in step (B).Type: ApplicationFiled: June 15, 2012Publication date: May 8, 2014Applicants: SEKISUI MEDICAL CO., LTD., SCHOOL JURIDICAL PERSON HIGASHI- NIPPON-GAKUENInventors: Masahiro Ieko, Chizuru Morikawa
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Publication number: 20140127726Abstract: Provided is a method of measuring blood coagulation time, the method being capable of LA detection easily and with high sensitivity as compared with the method recommended by the ISTH, without being affected by deficiency of blood coagulation factors even in a blood sample of a warfarin taker, a person who suffers from vitamin K deficiency, or a hepatic failure patient. Disclosed is a method of measuring the blood coagulation time to detect lupus anticoagulant, the method including adding a buffer solution composition containing blood coagulation factors to a blood sample before measurement or at the time of measurement of the blood coagulation time, and measuring the blood coagulation time.Type: ApplicationFiled: June 15, 2012Publication date: May 8, 2014Applicants: SEKISUI MEDICAL CO., LTD., SCHOOL JURIDICAL PERSON HIGASHI-NIPPON-GAKUENInventors: Masahiro Ieko, Chizuru Morikawa, Keiko Hattori
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Patent number: 8580532Abstract: To provide a method for stabilizing unstable ?-thrombin in a thrombin-containing solution, a solution containing stabilized ?-thrombin, and a liquid fibrinogen assay reagent containing the solution. The method for stabilizing ?-thrombin in a thrombin-containing solution, which includes adjusting the percentage of ?-thrombin to 70% or more with respect to the amount of total thrombin in the thrombin-containing solution.Type: GrantFiled: December 6, 2007Date of Patent: November 12, 2013Assignee: Sekisui Medical Co., Ltd.Inventors: Remi Ikeda, Chizuru Morikawa, Hirokazu Yago
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Publication number: 20120064553Abstract: Provided is a reagent, which prolongs a blood coagulation time sufficiently and enhances an optical change, thereby enabling a correct and high-sensitive blood coagulability test. The present invention provides a blood coagulation time prolonging agent, including, as an active ingredient, a guanidine compound represented by the following formula (1) or an acid addition salt thereof (in the formula, R1 represents a hydrogen atom, an amino group, or an alkyl group which may have a substituent).Type: ApplicationFiled: May 20, 2010Publication date: March 15, 2012Applicant: SEKISUI MEDICAL CO., LTDInventors: Chizuru Morikawa, Remi Nakamura, Mitsuaki Yamamoto
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Publication number: 20110129862Abstract: Provided is a method of accurately and easily determining a cause of the prolongation of blood coagulation time.Type: ApplicationFiled: June 16, 2009Publication date: June 2, 2011Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Remi Nakamura, Chizuru Morikawa, Hiroyuki Sunaga, Hirokazu Yago
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Publication number: 20100047834Abstract: To provide a method for stabilizing unstable ?-thrombin in a thrombin-containing solution, a solution containing stabilized ?-thrombin, and a liquid fibrinogen assay reagent containing the solution. The method for stabilizing ?-thrombin in a thrombin-containing solution, which includes adjusting the percentage of ?-thrombin to 70% or more with respect to the amount of total thrombin in the thrombin-containing solution.Type: ApplicationFiled: December 6, 2007Publication date: February 25, 2010Applicant: Sekisui Medical Co., Ltd.Inventors: Remi Ikeda, Chizuru Morikawa, Hirokazu Yago