Patents by Inventor Chloe J. A. Shea

Chloe J. A. Shea has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multi-tiered high through-put screen for compounds effective against bacterial biofilm and compounds effective for inhibiting and eradicating bacterial biofilm
    Patent number: 10704076
    Abstract: A high through-put screening method for identifying agents effective for inhibiting biofilm formation and/or killing established biofilm are disclosed. The method includes three tiers, and each tier includes three specific biological process assays. The tier levels are a primary screen, a confirmation screen, and a dose-response screen, and the biological process assays include assays for total bacterial growth, bacterial metabolic activity, and biofilm formation. The series of assays may be run once or more than once at each tier. A library of compounds is subject to tier A and only compounds meeting a primary parameter advance to tier B, and only tier B compounds meeting a confirmation parameter advance to tier C, and only tier C compounds meeting a dose-response parameter are identified as putative agents effective for inhibiting and/or eradicating a biofilm, further wherein the assays are conducted for each compound subject to the respective tier.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: July 7, 2020
    Assignees: University of Cincinnati, Government of the United States as Represented by the Secretary of the Air Force
    Inventors: Daniel J. Hassett, Thomas J. Lamkin, Warunya Panmanee, Deborah E. Taylor, Chloe J. A. Shea
  • MULTI-TIERED HIGH THROUGH-PUT SCREEN FOR COMPOUNDS EFFECTIVE AGAINST BACTERIAL BIOFILM AND COMPOUNDS EFFECTIVE FOR INHIBITING AND ERADICATING BACTERIAL BIOFILM
    Publication number: 20190127776
    Abstract: A high through-put screening method for identifying agents effective for inhibiting biofilm formation and/or killing established biofilm are disclosed. The method includes three tiers, and each tier includes three specific biological process assays. The tier levels are a primary screen, a confirmation screen, and a dose-response screen, and the biological process assays include assays for total bacterial growth, bacterial metabolic activity, and biofilm formation. The series of assays may be run once or more than once at each tier. A library of compounds is subject to tier A and only compounds meeting a primary parameter advance to tier B, and only tier B compounds meeting a confirmation parameter advance to tier C, and only tier C compounds meeting a dose-response parameter are identified as putative agents effective for inhibiting and/or eradicating a biofilm, further wherein the assays are conducted for each compound subject to the respective tier.
    Type: Application
    Filed: December 18, 2018
    Publication date: May 2, 2019
    Applicants: University of Cincinnati, Government of the United States as Represented by the Secretary of the Air Force
    Inventors: Daniel J. Hassett, Thomas J. Lamkin, Warunya Panmanee, Deborah E. Taylor, Chloe J.A. Shea
  • Multi-tiered, high through-put screen for compounds effective against bacterial biofilm compounds effective for inhibiting and eradicating bacterial biofilm
    Patent number: 10202631
    Abstract: A high through-put screening method for identifying agents effective for inhibiting biofilm formation and/or killing established biofilm are disclosed. The method includes three tiers, and each tier includes three specific biological process assays. The tier levels are a primary screen, a confirmation screen, and a dose-response screen, and the biological process assays include as says for total bacterial growth, bacterial metabolic activity, and biofilm formation.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 12, 2019
    Assignees: University of Cincinnati, The United States of America as Represented by the Secretary of the Air Force
    Inventors: Daniel J. Hassett, Thomas J. Lamkin, Warunya Panmanee, Deborah E. Taylor, Chloe J. A. Shea