Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: Described herein is a real-time communications system and a method of its operation. Structured datasets can be used to coordinate events. The data within a structured dataset may change dynamically (i.e., in real-time), and as such, can provide up-to-date information to a user. One or more associations can be used for making changes to the structured dataset(s) to facilitate information gathering in an organized fashion. Examples of the disclosure can further include using interactive elements embedded in a communication to allow a user to communicate information in an easier, more streamlined manner. The system further includes additional features to enhance the communications. These additional features include automatically updating members of a group, allowing the host (or the guest) the ability to send a broadcast message, allowing a guest the ability to create an interactive element embedded into a communication, and the ability to communicate with a system-allocated group.