Patents by Inventor Cho Yeow Koh

Cho Yeow Koh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Specific inhibitors of methionyl-tRNA synthetase
    Patent number: 10913736
    Abstract: The present disclosure is generally directed to compositions useful in the inhibition of MetRS and methods for treating diseases that are ameliorated by the inhibition of MetRS.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: February 9, 2021
    Assignee: University of Washington
    Inventors: Frederick S. Buckner, Ximena Barros Alvarez, Erkang Fan, John Robert Gillespie, Wilhelmus G.J. Hol, Wenlin Huang, Cho Yeow Koh, Ranae M. Ranade, Sayaka Shibata, Christophe L.M. Verlinde, Zhongsheng Zhang
  • Thrombin inhibitors
    Patent number: 10906946
    Abstract: The present invention provides isolated peptides, variants and fragments thereof that are capable of binding with a high level of specificity to thrombin and inhibiting its activity. There is also provided uses of such peptides in methods of diagnosis and treatment, coating of medical devices and nucleic acids encoding the same.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: February 2, 2021
    Assignees: National University of Singapore, Institute of Zoology, Slovak Academy of Sciences
    Inventors: Janaki Krishnamoorthy Iyer, Cho Yeow Koh, R. Manjunatha Kini, Maria Kazimirova, Ladislav Roller
  • NOVEL THROMBIN INHIBITORS
    Publication number: 20190002511
    Abstract: The present invention provides isolated peptides, variants and fragments thereof that are capable of binding with a high level of specificity to thrombin and inhibiting its activity. There is also provided uses of such peptides in methods of diagnosis and treatment, coating of medical devices and nucleic acids encoding the same.
    Type: Application
    Filed: June 17, 2016
    Publication date: January 3, 2019
    Applicants: National University of Singapore, Institute of Zoology, Slovak Academy of Sciences
    Inventors: Janaki Krishnamoorthy IYER, Cho Yeow KOH, R. Manjunatha KINI, Maria KAZIMIROVA, Ladislav ROLLER
  • SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE
    Publication number: 20170275279
    Abstract: The present disclosure is generally directed to compositions useful in the inhibition of MetRS and methods for treating diseases that are ameliorated by the inhibition of MetRS.
    Type: Application
    Filed: August 21, 2015
    Publication date: September 28, 2017
    Inventors: Frederick S. BUCKNER, Ximena Barros ALVAREZ, Erkang FAN, John Robert GILLESPIE, Wilhelmus G.J. HOL, Wenlin HUANG, Cho Yeow KOH, Ranae M. RANADE, Sayaka SHIBATA, Christophe L.M. VERLINDE, Zhongsheng ZHANG
  • Thrombin inhibitor
    Patent number: 9217027
    Abstract: The invention relates to thrombin inhibitors derived from the salivary glands of haematophagous arthropods and in particular to bivalent and trivalent thrombin inhibitors that act by interacting with thrombin at two or three different sites.
    Type: Grant
    Filed: June 18, 2008
    Date of Patent: December 22, 2015
    Assignee: Isis Innovation Limited
    Inventors: Maria Kazimtrova, R. Manjunatha Kini, Cho Yeow Koh
  • THROMBIN INHIBITOR
    Publication number: 20130183237
    Abstract: The invention relates to thrombin inhibitors derived from the salivary glands of haematophagous arthropods and in particular to bivalent and trivalent thrombin inhibitors that act by interacting with thrombin at two or three different sites.
    Type: Application
    Filed: June 18, 2008
    Publication date: July 18, 2013
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Maria Kazimirova, R. Manjunatha Kini, Cho Yeow Koh
  • METHOD OF MODIFYING SERINE PROTEASE INHIBITORS
    Publication number: 20120135931
    Abstract: The present invention relates to a method of modifying serine protease inhibitors in order to acquire or enhance any one of a variety of desired properties, including extent of inhibition, maintenance of inhibition following cleavage of the serine protease inhibitor by the target serine protease, speed of binding to the serine protease, neutralisation, and binding affinity. The present invention also relates to the products of such modifications and the uses of such products, in particular, their use in therapy.
    Type: Application
    Filed: May 5, 2010
    Publication date: May 31, 2012
    Applicant: NATURAL ENVIRONMENT RESEARCH COUNCIL
    Inventors: R. Manjunatha Kini, Cho Yeow Koh, Kunchithapadam Swaminathan, Kumar Sundramurthy