Patents by Inventor Choh Hao Li

Choh Hao Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • .beta.-Endorphin analogs
    Patent number: 4422968
    Abstract: The novel .beta.-endorphin analog [D-Ala.sup.2, Phe.sup.3, Gly.sup.4, Tyr.sup.5, Pro.sup.6 ]-.beta.-endorphin has been synthesized and has been found to be the most potent analog of .beta.-endorphin yet developed for inducing analgesia.
    Type: Grant
    Filed: September 13, 1982
    Date of Patent: December 27, 1983
    Assignee: The Regents of the University of California
    Inventor: Choh Hao Li
  • D-amino acid analogs of beta-endorphin
    Patent number: 4317770
    Abstract: D-amino acid analogs in positions 1,2,4 and 5 of .beta.-endorphin are synthesized by solid phase techniques. These compounds and, particularly [D-Ala.sup.2 ]-.beta.-endorphin, exhibit opiate agonist and analgesic activity.
    Type: Grant
    Filed: March 11, 1977
    Date of Patent: March 2, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Choh Hao Li
  • Analogs of human .beta.-endorphin
    Patent number: 4116950
    Abstract: Analogs of human .beta.-endorphin having a phenylalanine at position 27 and glycine at position 31 are disclosed. The subject analogs exhibit potent analgesic activity.
    Type: Grant
    Filed: January 16, 1978
    Date of Patent: September 26, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Choh Hao Li
  • Novel-enkephalin analogs
    Patent number: 4103005
    Abstract: Two enkephalin analogs, [D-Met.sup.2, Thz.sup.5 ]-enkephalinamide and [D-Thr.sup.2, Thz.sup.5 ]-enkephalinamide have been found to be potent analgesic agents.
    Type: Grant
    Filed: October 20, 1977
    Date of Patent: July 25, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Choh Hao Li
  • .beta.-Endorphin analog
    Patent number: 4098778
    Abstract: The .beta.-endorphin analog .beta.-endorphin (6-31), although lacking the enkephalin moiety i.e., .beta.-endorphin (1-5) exhibits analgesic activity which is not reversed by naloxone.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: July 4, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Choh Hao Li
  • Immunoassay for .beta.-endorphin
    Patent number: 4096237
    Abstract: A sensitive radioimmunoassay for .beta.-endorphin (.beta.-EP) is disclosed. It appears that the antigenic determinant resides in residues 6-15 of this molecule.
    Type: Grant
    Filed: March 14, 1977
    Date of Patent: June 20, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Choh Hao Li
  • Novel analogs of .beta.-endorphin
    Patent number: 4081434
    Abstract: Snythetic analogs of .beta.-endorphin having the sequence .beta.-endorphin-(1-5)-(16-31) are disclosed. These compounds are potent opiate agonists and analgesic agents, having activities in excess of the parent compounds. Moreover, the present analogs lack the antigenic determinent site which is believed to reside in residues 6-15 of .beta.-endorphin. Thus the analogs present a substantially reduced risk of inducing an anaphylactic response in a treated individual.
    Type: Grant
    Filed: March 11, 1977
    Date of Patent: March 28, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Choh Hao Li
  • Untriakontapeptide with opiate activity
    Patent number: 4038222
    Abstract: An untriakontapeptide having significant opiate agonist activity has been isolated from camel pituitary glands. The structure of this peptide has been determined and this peptide was then synthesized utilizing solid phase peptide synthesis. Both natural and synthetic material show identical physical and biological properties.
    Type: Grant
    Filed: March 17, 1976
    Date of Patent: July 26, 1977
    Assignee: Hoffman-La Roche Inc.
    Inventor: Choh Hao Li