Patents by Inventor Choji Taya

Choji Taya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatitis C animal model
    Patent number: 6429355
    Abstract: A hepatitis type C animal model into which cDNA derived from hepatitis C virus has been introduced. This animal model is useful for clarification of an onset mechanism of hepatitis C and as well as for development of means for treating the disease.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: August 6, 2002
    Assignees: Tokyo Metropolitan Institute of Medical Science, Chugai Seiyaku Kabushiki Kaisha
    Inventors: Michinori Kohara, Takaji Wakita, Hiromichi Yonekawa, Choji Taya, Izumu Saito
  • Transgenic mouse hepatitis C virus model comprising a hepatitis C viral fragment
    Patent number: 6201166
    Abstract: Transgenic mice are described which serve as a model for Hepatitis C infection. The transgenic mice contain, in their germline and somatic cells, the Hepatitis C viral fragment CN2, N24 or CR under the control of a Cre-loxP switch-expression system. Administration of Cre to the mice results in a phenotype of increased serum GTP levels, emergence of acidophilic bodies in the liver, exfoliation of hepatic cells, hypertrophy and hyperplasia of Kupffer's cells, and conglomeration of lymphocytes.
    Type: Grant
    Filed: January 21, 1999
    Date of Patent: March 13, 2001
    Assignee: Tokyo Metropolitan Institute of Medical Science
    Inventors: Michinori Kohara, Takaji Wakita, Hiromichi Yonekawa, Choji Taya, Izumu Saito
  • Transgenic animal allergy models and methods for their use
    Patent number: 6118044
    Abstract: Transgenic mice which constitutively express an antibody-type molecule encoded by the transgene and which has an IgE heavy chain constant region and is specific for a pre-defined antigen, provide an allergic reaction to that antigen without prior sensitization and are useful as allergy models.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: September 12, 2000
    Assignees: Sankyo Company, Limited, The Tokyo Metropolitan Institute of Medical Science
    Inventors: Hajime Karasuyama, Hiromichi Yonekawa, Choji Taya, Kunie Matsuoka
  • Method for examining neurovirulence of polio virus
    Patent number: 5986171
    Abstract: The present invention relates to a method of examining the neurovirulence of a polio virus, which comprises inoculating a polio virus into the spinal cord of a transgenic mouse comprising a gene for a polio virus receptor.
    Type: Grant
    Filed: November 15, 1995
    Date of Patent: November 16, 1999
    Assignees: Japan Poliomyelitis Research Institute, Central Institute for Experimental Animals
    Inventors: Shinobu Abe, Yoshihiro Ota, So Hashizume, Satoshi Koike, Akio Nomoto, Hiromichi Yonekawa, Choji Taya, Tatsuji Nomura