Patents by Inventor Chong-Heng Huang

Chong-Heng Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solvent system enhancing the solubility of pharmaceuticals for encapsulation
    Patent number: 5360615
    Abstract: This invention relates to a solvent system for enhancing the solubility of an acidic, basic, or amphoteric pharmaceutical agent to produce a highly concentrated solution suitable for softgel filling or two piece encapsulation. The solvent system comprises polyethylene glycol containing 0.2-1.0 mole equivalents of an ionizing agent per mole equivalent pharmaceutical agent and 1-20% water. Glycerin or polyvinylpyrrolidone may be added to further enhance the solubility of certain drugs. The disclosed solvent system is capable of enhancing solubilities of pharmaceutical agents 40-400%.The ionizing agent functions by causing partial ionization (neutralization) of the free pharmaceutical agent. When the pharmaceutical agent is acidic, the ionizing agent is preferably a hydroxide ion species, whereas when the pharmaceutical agent is basic, the ionizing agent is preferably a hydrogen ion species.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: November 1, 1994
    Assignee: R. P. Scherer Corp.
    Inventors: Man S. Yu, Foo S. Hom, Sibaprasanna Chakrabarti, Chong-Heng Huang, Mahendra Patel
  • Solvent system enhancing the solubility of pharmaceuticals for encapsulation
    Patent number: 5071643
    Abstract: This invention relates to a solvent system for enhancing the solubility of an acidic, basic, or amphoteric pharmaceutical agent to produce a highly concentrated solution suitable for softgel filling or two piece encapsulation. The solvent system comprises polyethylene glycol containing 0.2-1.0 mole equivalents of an ionizing agent per mole equivalent pharmaceutical agent and 1-20% water. Glycerin or polyvinylpyrrolidone may be added to further enhance the solubility of certain drugs. The disclosed solvent system is capable of enhancing solubilities of pharmaceutical agents 40-400%.The ionizing agent functions by causing partial ionization (neutralization) of the free pharmaceutical agent. When the pharmaceutical agent is acidic, the ionizing agent is preferably a hydroxide ion species, whereas when the pharmaceutical agent is basic, the ionizing agent is preferably a hydrogen ion species.
    Type: Grant
    Filed: October 9, 1987
    Date of Patent: December 10, 1991
    Assignee: R. P. Scherer Corporation
    Inventors: Man S. Yu, Foo S. Hom, Sibaprasanna Chakrabarti, Chong-Heng Huang, Mahendra Patel