Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.

Abstract: Disclosed are crystalline forms of the compound of formula (I): (I) Also disclosed are compositions containing the crystalline forms of the compound of formula (I) and methods of their use. The methods may be for treating cancer in a subject in need thereof, e.g., by administering to the subject an effective amount of the crystalline form disclosed herein or its composition.

Abstract: Provided is a method of determining a mission of a device in an electronic device, including identifying external situation information and status information of a plurality of devices, identifying an object function related to a degree of fitness of a device for a mission, for each set of a plurality of solutions of a first generation for the plurality of devices, calculating a value of the object function using the external situation information and the status information, based on the value, determining a set of a plurality of solutions of a next generation for the plurality of devices through a genetic algorithm (GA), and based on a first solution from a set of a plurality of solutions of a second generation by repeating the calculating the value and the determining the set of the plurality of solutions of the next generation, determining a mission for the plurality of devices.

Abstract: Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.

Abstract: Provided are solid forms of a compound useful for treating cancer, pharmaceutical compositions thereof, and methods of treating cancer comprising administering the solid forms described herein to a patient in need thereof.

Abstract: The present disclosure features citrate salts and pharmaceutical compositions useful for the treatment of BAF complex-related disorders. Also disclosed are methods for preparing compounds.

Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.

Abstract: The present invention relates to a reducer (10) comprising: a hollow input shaft (100) having a driving surface (110) therein; an output shaft (200) which is accommodated inside the input shaft (100) and having an output shaft body (210) having an output shaft gear (220) formed along the circumferential direction on the outer surface; a plurality of rollers (R) aligned between the output shaft (200) and the driving surface (110) and extending in the axial direction; and ring-shaped caps (300) positioned on both sides of the axial direction of the rollers (R), wherein the rollers (R) are guided to move in the radial direction by means of the caps (300) and, when the input shaft (100) rotates, the rollers (R) are pressurized against the driving surface (110) to pressurize the output shaft gear (200), so that the output shaft (200) rotates.

Abstract: The present disclosure features citrate salts and pharmaceutical compositions useful for the treatment of BAF complex-related disorders. Also disclosed are methods for preparing compounds.

Abstract: Provided are compounds and pharmaceutical compositions useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound or pharmaceutical composition described herein.

Abstract: Provided are solid forms of a compound useful for treating cancer, pharmaceutical compositions thereof, and methods of treating cancer comprising administering the solid forms described herein to a patient in need thereof.

Abstract: Provided herein is a tablet comprising 2-methyl-1-[(4-[-6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.

Abstract: A ribozyme comprising a target-binding domain, a polynucleotide encoding the same, a kit comprising the same, and uses thereof.

Abstract: Provided herein is a tablet comprising 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol or a pharmaceutically acceptable salt thereof.

Abstract: Provided are solid forms of a compound useful for treating cancer, pharmaceutical compositions thereof, and methods of treating cancer comprising administering the solid forms described herein to a patient in need thereof.

Abstract: Provided are formulations of ivosidenib including a number of polymorphs. Further provided are formulations of ivosidenib containing a number of known impurities. Still further provided are stable compositions of ivosidenib.

Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.

Abstract: Provided are solid forms of a compound useful for treating cancer, pharmaceutical compositions thereof, and methods of treating cancer comprising administering the solid forms described herein to a patient in need thereof.

Abstract: Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.