Abstract: A 2-piperidyl or 2-pyrazolyl substituted pyrimidine compound, which is a compound represented by formula (I) or a pharmaceutically acceptable salt, an isotopic variant, a tautomer, a stereoisomer, a prodrug, a polymorph, a hydrate or a solvate thereof. A pharmaceutical composition comprising the compound, and a use of the pharmaceutical composition in the treatment of diseases mediated by an EGFR protein and mutants thereof.

Abstract: The present disclosure belongs to the technical field of casting, and specifically relates to a high-inertia mold shell for casting, a preparation method thereof, and a method for improving precision of a magnesium alloy cast. The high-inertia mold shell for casting includes a surface layer, which is configured to contact a magnesium alloy pouring liquid, wherein the surface layer contains an inorganic compound, and the inorganic compound is at least one selected from the group consisting of boric anhydride, borax, potassium fluoride, and sodium fluoride; and in the above, based on a total amount of raw materials of the surface layer, a content of the inorganic compound accounts for 10-40 wt %.

Abstract: According to one exemplary method, the method includes classifying image pixels in each video image of a series of video images as either foreground or background. The method also includes replacing each pixel classified as background with a time-averaged value of pixel intensity for that pixel. The method further includes compressing the video images using a compression algorithm.

Abstract: Methods, systems, and non-transitory computer readable media for reconstructing electronic images using blurring and noise-enhanced pixel intensity resampling are disclosed. One method includes, at an image reconstructor including at least one processor, receiving an image compressed using an image compression algorithm. The method further includes decompressing the image using an image decompression algorithm. The method further includes modifying pixel intensities in the image by blurring and/or resampling the pixel intensities according to a noise distribution generated by the reconstructor without receiving a noise estimate from an image compressor. The method further includes outputting the image with the modified pixel intensities.

Abstract: Methods, systems, and non-transitory computer readable media for reconstructing electronic images using blurring and noise-enhanced pixel intensity resampling are disclosed. One method includes, at an image reconstructor including at least one processor, receiving an image compressed using an image compression algorithm. The method further includes decompressing the image using an image decompression algorithm. The method further includes modifying pixel intensities in the image by blurring and/or resampling the pixel intensities according to a noise distribution generated by the reconstructor without receiving a noise estimate from an image compressor. The method further includes outputting the image with the modified pixel intensities.

Abstract: Methods, systems, and computer readable media for compressing video images are disclosed. According to one exemplary method, the method includes classifying image pixels in each video image of a series of video images as either foreground or background. The method also includes replacing each pixel classified as background with a time-averaged value of pixel intensity for that pixel. The method further includes compressing the video images using a compression algorithm.