Patents by Inventor Chong Si

Chong Si has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED FUSED AZINES AS KRAS G12D INHIBITORS
    Publication number: 20240228511
    Abstract: The present invention provides compounds of the formula where R1, R2, R3, R4a, R4b, R4c, R5, R6, X, Y, and Z are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.
    Type: Application
    Filed: June 8, 2022
    Publication date: July 11, 2024
    Inventors: David Anthony BARDA, Joshua Ryan CLAYTON, Jeffry Bernard FRANCISKOVICH, Kelly Wayne FURNESS, Douglas Linn GERNERT, James Robert HENRY, Richard Duane JOHNSTON, Spencer Brian JONES, Jason Eric LAMAR, Adam Marc LEVINSON, Curren Tapfuma MBOFANA, Michael John RODRIQUEZ, Almudena RUBIO, Chong SI, Gaiying ZHAO, Mohammed Sadegh ZIA-EBRAHIMI
  • KRAS G12C INHIBITOR DOSING REGIMENS
    Publication number: 20240108618
    Abstract: Disclosed herein are dosing regimens for the administration of a compound of Formula I: or pharmaceutically acceptable salt thereof, or in combination with one or more of a second therapeutic agent, to a patient in need of such treatment.
    Type: Application
    Filed: June 29, 2023
    Publication date: April 4, 2024
    Inventors: David Michael HYMAN, Xueqian GONG, Sheng-Bin PENG, Chong SI, Melinda Dale WILLARD
  • KRAS INHIBITORS
    Publication number: 20240043451
    Abstract: The present invention provides compounds of the formula: wherein A, B, D1, X, Y, Z, G, R1, R2, and R3a are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.
    Type: Application
    Filed: March 24, 2023
    Publication date: February 8, 2024
    Inventors: David Anthony BARDA, Jolie Anne BASTIAN, Kelly Wayne FURNESS, Deqi GUO, James Robert HENRY, Richard Duane JOHNSTON, Jason Eric LAMAR, Tao LIU, Michael John RODRIGUEZ, Almudena RUBIO, Chong SI, Gaiying ZHAO, Mohammad Sadegh ZIA-EBRAHIMI, Matthew Patrick BAUMGARTNER, Isabel ROJO, Mario BARBERIS, Santiago CARBALLARES MARTIN, Pablo GARCIA LOSADA, Sonia Maria GUTIERREZ SANFELICIANO, Wenceslao LUMERAS AMADOR, Victoriano MOLERO FLOREZ, Maria Lourdes PRIETO VALLEJO
  • KRAS G12C INHIBITORS
    Publication number: 20240025916
    Abstract: The present disclosure provides compounds of the formula: where R1, R2, R3, R4, R5, A, and B are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and salts for treating patients for cancer.
    Type: Application
    Filed: November 24, 2021
    Publication date: January 25, 2024
    Inventors: David Michael HYMAN, Gregory Lawrence LACKNER, Sheng-Bin PENG, Bree Leigh RICHEY, Chong SI
  • KRAS Gl2C INHIBITORS
    Publication number: 20230339968
    Abstract: The present invention provides compounds of the formula: where R1, R2, R3, R4, R5, A, B, and Y are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and salts for treating patients for cancer.
    Type: Application
    Filed: June 28, 2023
    Publication date: October 26, 2023
    Inventors: Serge Louis BOULET, Kevin Charles FORTNER, Deqi GUO, David Michael HYMAN, Sheng-Bin PENG, Chong SI
  • KRas G12C inhibitors
    Patent number: 11731984
    Abstract: The present invention provides compounds of the formula: where R1, R2, R3, R4, R5, A, B, and Y are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and salts for treating patients for cancer.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: August 22, 2023
    Assignee: Eli LIlly and Company
    Inventors: Serge Louis Boulet, Kevin Charles Fortner, Deqi Guo, David Michael Hyman, Sheng-Bin Peng, Chong Si
  • KRAS G12C INHIBITORS
    Publication number: 20210179633
    Abstract: The present invention provides compounds of the formula: where R1, R2, R3, R4, R5, A, B, and Y are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and salts for treating patients for cancer.
    Type: Application
    Filed: December 4, 2020
    Publication date: June 17, 2021
    Inventors: Serge Louis BOULET, Kevin Charles FORTNER, Deqi GUO, David Michael HYMAN, Sheng-Bin PENG, Chong SI
  • Cortistatin analogues and syntheses thereof
    Patent number: 10202400
    Abstract: The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: and salts thereof, wherein R1, R2, R3, R4, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin A, J, K, and L, and analogs thereof.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: February 12, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Alec Nathanson Flyer, Hong Myung Lee, Andrew G. Myers, Cristina Montserrat Nieto-Oberhuber, Matthew D. Shair, Chong Si
  • CORTISTATIN ANALOGUES AND SYNTHESES THEREOF
    Publication number: 20170320886
    Abstract: The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: and salts thereof, wherein R1, R2, R3, R4, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin A, J, K, and L, and analogs thereof.
    Type: Application
    Filed: July 24, 2017
    Publication date: November 9, 2017
    Applicant: President and Fellows of Harvard College
    Inventors: Alec Nathanson Flyer, Hong Myung Lee, Andrew G. Myers, Cristina Montserrat Nieto-Oberhuber, Matthew D. Shair, Chong Si Allston
  • 1-oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonamide compounds, formulations containing those compounds, and their use as AICARFT inhibitors in the treatment of cancers
    Patent number: 9776992
    Abstract: 1-Oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonamide compounds, formulations containing those compounds, and their use as AICARFT inhibitors.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: October 3, 2017
    Assignee: Eli Lilly and Company
    Inventors: Harold Burns Brooks, Robert Dean Dally, Timothy Barrett Durham, Kevin Robert Fales, Kwame Frimpong, Jefferson Ray McCowan, Frank George Njoroge, Timothy Alan Shepherd, Chong Si, Kenneth Jeff Thrasher, James Lee Toth, Zhipei Wu
  • 1-OXO-1,2-DIHYDROISOQUINOLIN-7-YL-(5-SUBSTITUTED-THIOPHEN-2-YL)-SULFONAMIDE COMPOUNDS, FORMULATIONS CONTAINING THOSE COMPOUNDS, AND THEIR USE AS AICARFT INHIBITORS IN THE TREATMENT OF CANCERS
    Publication number: 20170233378
    Abstract: 1-Oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonamide compounds, formulations containing those compounds, and their use as AICARFT inhibitors.
    Type: Application
    Filed: November 24, 2015
    Publication date: August 17, 2017
    Applicant: Eli Lilly and Company
    Inventors: Harold Burns BROOKS, Robert Dean DALLY, Timothy Barrett DURHAM, Kevin Robert FALES, Kwame FRIMPONG, Jefferson Ray MCCOWAN, Frank George NJOROGE, Timothy Alan SHEPHERD, Chong SI, Kenneth Jeff THRASHER, James Lee TOTH, Zhipei WU
  • Cortistatin analogues and syntheses thereof
    Patent number: 9714255
    Abstract: The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: and salts thereof, wherein R1, R2, R3, R4, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin A, J, K, and L, and analogs thereof.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: July 25, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Alec Nathanson Flyer, Hong Myung Lee, Andrew G. Myers, Cristina Montserrat Nieto-Oberhuber, Matthew D. Shair, Chong Si
  • CORTISTATIN ANALOGUES AND SYNTHESES THEREOF
    Publication number: 20150376201
    Abstract: The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: and salts thereof, wherein R1, R2, R3, R4, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin A, J, K, and L, and analogs thereof.
    Type: Application
    Filed: September 8, 2015
    Publication date: December 31, 2015
    Applicant: President and Fellows of Harvard College
    Inventors: Alec Nathanson Flyer, Hong Myung Lee, Andrew G. Myers, Cristina Montserrat Nieto-Oberhuber, Matthew D. Shair, Chong Si
  • Cortistatin analogues and synthesis thereof
    Patent number: 9127019
    Abstract: The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: I and salts thereof, wherein R1, R2, R3, R4, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin A, J, K, and L, and analogs thereof.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: September 8, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Alec Nathanson Flyer, Hong Myung Lee, Andrew G. Myers, Cristina Montserrat Nieto-Oberhuber, Matthew D. Shair, Chong Si
  • CORTISTATIN ANALOGUES AND SYNTHESES THEROF
    Publication number: 20150111921
    Abstract: The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: I and salts thereof, wherein R1, R2, R3, R4, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin A, J, K, and L, and analogs thereof.
    Type: Application
    Filed: June 2, 2014
    Publication date: April 23, 2015
    Applicant: President and Fellows of Harvard College
    Inventors: Alec Nathanson Flyer, Hong Myung Lee, Andrew G. Myers, Cristina Montserrat Nieto-Oberhuber, Matthew D. Shair, Chong Si
  • CORTISTATIN ANALOGUES AND SYNTHESES THEREOF
    Publication number: 20110190323
    Abstract: The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: I and salts thereof, wherein R1, R2, R3, R4, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin A, J, K, and L, and analogs thereof.
    Type: Application
    Filed: August 28, 2009
    Publication date: August 4, 2011
    Applicant: President and Fellows of Harvard College
    Inventors: Alec Nathanson Flyer, Hong Myung Lee, Andrew G. Myers, Cristina Montserrat Nieto-Oberhuber, Matthew D. Shair, Chong Si
  • Multiple downcomer fractionation tray having packing between downcomers
    Patent number: 5366666
    Abstract: The invention improves the performance of Multiple Downcomer fractionation trays and comprises placing a bed-like layer of packing material closely adjacent the bottom surface of the tray. The packing is located in the so-called "disengagement" zone under the tray and does not extend down to the tray below. Means comprising perforations in the downcomer sidewalls are provided to spread liquid from the tray above onto the packing material.
    Type: Grant
    Filed: October 13, 1993
    Date of Patent: November 22, 1994
    Assignee: UOP
    Inventors: Karl T. Chuang, Chong-Si Xu, Guangxia Chen
  • Fractionation tray having packing immediately below tray deck
    Patent number: 5262094
    Abstract: The invention improves the performance of fractionation trays and comprises placing a bed-like layer of packing material closely adjacent the bottom surface of the tray. The packing is located in the so-called "disengagement" zone under the tray and does not extend down to the tray below. Means are provided to spread liquid from the tray above onto the packing material.
    Type: Grant
    Filed: September 8, 1992
    Date of Patent: November 16, 1993
    Assignee: UOP
    Inventors: Karl T. Chuang, Chong-Si Xu, Guangxia Chen