Patents by Inventor Chonghao Liu

Chonghao Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-substituent-2-hydroxylmorpholine-3-one and preparation method thereof
    Patent number: 9676736
    Abstract: A molecule with neural activities, especially 4-substituent-2-hydroxymorpholin-3-one, as a new intermediate of neurokinin-1 receptor antagonist aprepitant, and preparation method thereof.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: June 13, 2017
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Fuli Zhang, Chonghao Liu, Pengcheng Qiu, Jian Chai, Qingfeng Cai
  • Method for preparing rivaroxaban intermediate
    Patent number: 9079892
    Abstract: A method for preparing a Rivaroxaban intermediate I is presented, including the following step: in a non-protonic solvent, under the effect of lewis acid, performing cyclization reaction on 4-(4-phenyl isocyanate)morpholine-3-ketone (II) and (S)-epoxy compound (III), the reaction temperature ranging from 20° C. to 60° C., where R is amino replaced by amino protecting group. The preparation method of the present invention has a mild condition, a simple process, a low cost, and high efficiency; the product is easy to purify and the method is applicable to industrial production.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: July 14, 2015
    Assignees: CHINA NATIONAL MEDICINES GUORUI PHARMACEUTICAL CO., LTD., SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY
    Inventors: Fuli Zhang, Bin Liang, Chunbo Yang, Chonghao Liu, Yang Gao, Jian Wang, Min Jiang
  • 4-SUBSTITUENT-2-HYDROXYLMORPHOLINE-3-ONE AND PREPARATION METHOD THEREOF
    Publication number: 20150087828
    Abstract: A molecule with neural activities, especially 4-substituent-2-hydroxymorpholin-3-one, as a new intermediate of neurokinin-1 receptor antagonist aprepitant, and preparation method thereof.
    Type: Application
    Filed: April 15, 2013
    Publication date: March 26, 2015
    Applicants: Zhejiang Hisun Pharmaceutical Co., Ltd., Shanghai Institute of Pharmaceutical Industry
    Inventors: Fuli Zhang, Chonghao Liu, Pengcheng Qiu, Jian Chai, Qingfeng Cai
  • METHOD FOR PREPARING RIVAROXABAN INTERMEDIATE
    Publication number: 20150038704
    Abstract: A method for preparing a Rivaroxaban intermediate I is presented, including the following step: in a non-protonic solvent, under the effect of lewis acid, performing cyclization reaction on 4-(4-phenyl isocyanate)morpholine-3-ketone (II) and (S)-epoxy compound (III), the reaction temperature ranging from 20° C. to 60° C., where R is amino replaced by amino protecting group. The preparation method of the present invention has a mild condition, a simple process, a low cost, and high efficiency; the product is easy to purify and the method is applicable to industrial production.
    Type: Application
    Filed: February 22, 2013
    Publication date: February 5, 2015
    Applicants: China National Medicines Guorui Pharmaceutical Co., Shanghai Institute of Pharmaceutical Industry
    Inventors: Fuli Zhang, Bin Liang, Chunbo Yang, Chonghao Liu, Yang Gao, Jian Wang, Min Jiang