Abstract: Engineered bispecific antibodies with charge pairs introduced at the interface of CHI and CL alone or in combination with other charge pairs at the interface of VH and VL are described. Also described are anti-CD47/anti-CLDN18.2 and anti-CD3/anti-DLL3 bispecific antibodies and antigen-binding fragments thereof. Also described are nucleic acids encoding the bispecific antibodies, compositions comprising the bispecific antibodies, and methods of producing the bispecific antibodies and using the bispecific antibodies for treating or preventing diseases, such as cancer and/or associated complications.

Abstract: Provided by the present application are a Direct Current (DC) micro-grid system, a charging loop circuit and a control method thereof. The charging loop circuit selectively connects a charging loop to a first side loop or a second side loop through a set of switches.

Abstract: The present disclosure provides an interpreter of a reconfigurable cryptographic algorithm based on customized high-level C language, in the field of information security. The interpreter includes an input program of cryptographic algorithm customized language, a compilation optimization module, an intermediate file and data flow graph generation module, a mapping module and an array generation configuration code module. The disclosure provides an automatic mapping tool for the reconfigurable processor, which can take customized high-level C language as input, and the interpreter arranges and connects computing units like operators according to the input high-level C program, to complete the mapping of the whole computing function.

Abstract: Monoclonal antibodies (mAbs) or bispecific antibodies (bsAbs) or multi-specific antibodies comprising a fatty acid (FA) molecule conjugated to or near the antigen-binding domain are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases, such as cancer and/or associated complications.

Abstract: The present disclosure discloses an information security application-oriented reconfigurable system chip compiler and an automatic compilation method. The method includes the following steps: firstly, inputting a source program of a cryptographic algorithm; then, executing a software compilation function syntax check of the source program, and when the check result is passed, performing compilation mapping using a compiler; next, executing the cryptographic algorithm by simulation running using a simulator, and generating a configuration code by a simulator array; and finally, guiding a hardware behavior operation using a binary configuration code file generated by the simulator. The reconfigurable system chip compiler includes a source program input module, a software compilation function verification module, a compilation mapping module, a simulation execution module, a configuration code generation module, and a hardware debugging module.

Abstract: Engineered bispecific antibodies with shifted interchain disulfide bond on one arm while maintaining the native interchain disulfide bond on the second arm are described. Also described are anti-CD47/FR? bispecific antibodies and antigen-binding fragments thereof. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases, such as cancer and/or associated complications.

Abstract: An ultrasonic gas sensor includes a housing, and a first ultrasonic transducer and a second ultrasonic transducer that are separately arranged at a top of an inner chamber of the housing, where the first ultrasonic transducer and the second ultrasonic transducer form a V-shaped ultrasonic transmission path in the housing; the housing is provided therein with a gas inlet channel and a gas outlet channel; an upper end of the gas inlet channel is close to the first ultrasonic transducer, and an upper end of the gas outlet channel is close to the second ultrasonic transducer, such that a measured gas flow entering a bypass tube passes through a detection area of the first ultrasonic transducer and the second ultrasonic transducer; a lower end of the gas inlet channel and a lower end of the gas outlet channel communicate with a gas sensor mount.

Abstract: An onsite steel rail laser processing engineering vehicle, including a laser processing power engineering vehicle and a laser processing cart, the laser processing power engineering vehicle is connected to the laser processing cart; the onsite steel rail laser processing engineering vehicle further comprises a transport mechanism disposed on the laser processing power engineering vehicle; through movement and rotation, the transport mechanism transports the laser processing cart into the laser processing power engineering vehicle or transports the laser processing cart out from the laser processing power engineering vehicle and places it on rails.

Abstract: An onsite steel rail laser processing engineering vehicle, including a laser processing power engineering vehicle and a laser processing cart, the laser processing power engineering vehicle is connected to the laser processing cart; the onsite steel rail laser processing engineering vehicle further comprises a transport mechanism disposed on the laser processing power engineering vehicle; through movement and rotation, the transport mechanism transports the laser processing cart into the laser processing power engineering vehicle or transports the laser processing cart out from the laser processing power engineering vehicle and places it on rails.

Abstract: Provided are a method and an apparatus for laser quenching. The method utilizes a scanning galvanometer, and involves laser quenching via irradiation with intermittent, repeated scans, rather than a single scan as in the prior art. The method results in increased laser energy absorbed by the metal base and improved depth of thermal conduction, while avoiding melting at the metal surface, thus providing a significantly improved laser quenching process. The apparatus can include a laser, a control system, a light guiding system, a mechanical motion device and a galvanometer.

Abstract: The invention discloses an on-line laser processing vehicle for a rail, including a chassis, a vehicle body, a steer-control chamber and a container; the steer-control chamber includes a console, a CCD monitoring system and a drive-switching operating system; a dual driving system and switching mechanism, which with a process-operation driving system, a conventional operation driving system and a switching mechanism, is disposed in the container; the process-operation driving system operates to provide driving power for the laser processing vehicle during laser processing, and precisely controls moving speed and distance of the laser processing vehicle; the switching mechanism operates to implement switching between the conventional operation driving system and the process-operation driving system.

Abstract: Provided are a method and an apparatus for laser quenching. The method takes the advantage of a high jumping speed of a scanning galvanometer, and adopts the method of heating on multiple or even high frequency repeated scans instead of on a single scan in prior art for laser quenching, wherein the laser energy is fed into the surface of a workpiece by way of short time and multiple superimposed heating, cumulatively, the laser energy absorbed by the metal base is increased and the depth of thermal conduction is improved also. The apparatus includes a laser, a control system, a light guiding system, a mechanical motion device and a scanning galvanometer.

Abstract: The invention discloses an on-line laser processing vehicle for a rail, including a chassis, a vehicle body, a steer-control chamber and a container; the steer-control chamber includes a console, a CCD monitoring system and a drive-switching operating system; a dual driving system and switching mechanism, which with a process-operation driving system, a conventional operation driving system and a switching mechanism, is disposed in the container; the process-operation driving system operates to provide driving power for the laser processing vehicle during laser processing, and precisely controls moving speed and distance of the laser processing vehicle; the switching mechanism operates to implement switching between the conventional operation driving system and the process-operation driving system.