Patents by Inventor Choy L. Hew

Choy L. Hew has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sculpin-type antifreeze polypeptides and nucleic acids
    Patent number: 6429293
    Abstract: The present invention provides inter alia, isolated “sculpin-type intracellular AFPs” from shorthorn sculpin and their corresponding nucleic acids. The sculpin-type intracellular AFPs are alanine-rich polypeptides that are synthesized in the peripheral tissues such as the skin and gills of fish. These skin-type AFPs are encoded by a distinct set of AFP genes that lack a signal peptide, which is indicative of their intracellular location. The polypeptides are used to make cells cold resistant and to improve the palatability of cold foods and liquids. Cold resistant eukaryotes and prokaryotes, including plants, animals and bacteria are made using the sculpin-type intracellular antifreeze polypeptides and nucleic acids. Moreover, the present invention provides methods for preserving cells, tissues and organs ex vivo using the AFPs described herein.
    Type: Grant
    Filed: June 24, 1999
    Date of Patent: August 6, 2002
    Assignee: HSC Research and Development Limited Partnership
    Inventor: Choy L. Hew
  • Antifreeze polypeptide-expressing microorganisms useful in fermentation and frozen storage of foods
    Patent number: 6174550
    Abstract: Methods and compositions for preparation of frozen fermented food products using antifreeze polypeptide-expressing microorganisms are provided. In particular the invention provides for use of fish antifreeze polypeptide-expressing microorganisms in fermentation of milk to produce and store frozen yogurt.
    Type: Grant
    Filed: October 13, 1997
    Date of Patent: January 16, 2001
    Assignees: Seabright Corporation Limited, HSC Research and Development Limited Partnership
    Inventors: Garth L. Fletcher, Choy L. Hew, Shashikant B. Joshi, Yaling Wu
  • Antifreeze polypeptide-expressing microorganisms useful in fermentation and freezing of foods
    Patent number: 5676985
    Abstract: Methods and compositions for preparation of frozen fermented food products using antifreeze polypeptide-expressing microorganisms are provided. In particular the invention provides for use of fish antifreeze polypeptide-expressing microorganisms in fermentation of milk to produce and store frozen yogurt.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: October 14, 1997
    Assignee: HSC Research and Development Limited Partnership
    Inventors: Garth L. Fletcher, Choy L. Hew, Shashikant B. Joshi, Yaling Wu
  • Transgenic salmonid fish expressing exogenous salmonid growth hormone
    Patent number: 5545808
    Abstract: An "all fish" chimeric gene construct suitable for gene transfer for commercially important fish comprises the antifreeze gene (AFP) promoter fused to the desired gene sequence which is incorporated into fish embryos. The desired gene sequence is expressed in the transfected fish to provide a transgenic fish having the characteristics of the gene sequence.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: August 13, 1996
    Assignees: HSC Research and Development Limited Partnership, Seabright Corporation
    Inventors: Choy L. Hew, Garth L. Fletcher
  • Determination of genomic sex in salmonids
    Patent number: 5480774
    Abstract: The invention provides a method for determining the genomic sex of various salmonids (family salmonidae). In particular, the invention provides the nucleic acid sequence of a pseudogene, designated GH-.PSI., which is linked to a sex determining locus on the Y chromosome, and may be used as a marker for determination of the sex of the fish.
    Type: Grant
    Filed: October 14, 1993
    Date of Patent: January 2, 1996
    Assignee: A/F Protein, Inc.
    Inventors: Choy L. Hew, Shao J. Du