Patents by Inventor Chris A. Buhr

Chris A. Buhr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydrogen phosphonodithioate compositions
    Patent number: 5194599
    Abstract: Novel hydrogen-phosphonodithioate compositions are provided which are particularly useful for forming internucleotide and internucleoside linkages in oligonucleosides or oligonucleotides. The oligonucleotides and analogs thereof made by using the hydrogen-phosphonodithioate compositions may be therapeutically useful as antiviral and anticancer agents and may have other therapeutic or diagnostic uses. A method for making the hydrogen-phosphonodithioates is provided as well as a method for converting same to an activated intermediate for substitution on the phosphorus atom.
    Type: Grant
    Filed: September 23, 1988
    Date of Patent: March 16, 1993
    Assignee: Gilead Sciences, Inc.
    Inventors: Brian C. Froehler, Chris A. Buhr