Abstract: Apparatus, systems, and methods for controlling light output in a lighting system based on defined light profiles are provided. In one example implementation, a light fixture can include a first light emitting diode (LED) array having one or more LED light sources and a second LED array having one or more LED light sources. The light fixture can include a power circuit configured to provide power to the first LED array and the second LED array according to a power distribution among the first LED array and the second LED array. The light fixture can include one or more control devices configured to control the power circuit to adjust the power distribution among the first LED array and the second LED array based at least in part on a signal indicative of a real time clock and a defined light profile associated with a user identified to be present in a space illuminated by the light fixture.

Abstract: A method of operating a mobile cleaning robot can include navigating the mobile cleaning robot within an environment. A vacuum system of the mobile cleaning robot can be operated to ingest debris from the environment Whether a dispense condition is satisfied can be determined. Fluid can be dispensed from the mobile cleaning robot when the dispense condition is satisfied.

Abstract: Provided herein are compounds that modulate RMB39 and methods of using the compounds in RMB39-associated disorders, such as cancer (e.g., renal cell carcinoma).

Abstract: Provided are variants of a chimeric anti-EGFR antibody. In various embodiments, the variants exhibit substantially improved thermostabilities and/or substantially higher levels of humanness, while retaining binding affinity near the parental level. The consistently high quality of the turnkey CoDAH designs, over a whole panel of variants, suggests that a computationally-directed approach encapsulates key determinants of antibody structure and function.

Abstract: Deimmunized botulinum toxin light chain (e.g., botulinum toxin serotype A light chains (BoNT/A-LC)) or fragments thereof are provided. Methods for treating or preventing diseases or disorders comprising administering to a subject a deimmunized botulinum toxin light chain (e.g., BoNT/A-LC) are provided.

Abstract: Multi-function lighting fixtures are provided. In one example implementation, a lighting fixture may include an optical housing extending lengthwise between a first end and a second end. The optical housing may include a plurality of light sources disposed within an interior of the optical housing and a plurality of optical elements disposed along an exterior of the optical housing. The optical housing may also a plurality of sections defined within the interior of the optical housing. Each of the optical sections may be associated with a separate light source of the plurality of light sources and a separate optical element of the plurality of optical elements.

Abstract: Compositions comprising deimmunized lysostaphin and methods of using the same, e.g., to treat microbial infection in or on a subject, are provided.

Abstract: Compositions comprising deimmunized lysostaphin and methods of using the same, e.g., to treat microbial infection in or on a subject, are provided.

Abstract: Multi-function lighting fixtures are provided. In one example implementation, a lighting fixture may include an optical housing extending lengthwise between a first end and a second end. The optical housing may include a plurality of light sources disposed within an interior of the optical housing and a plurality of optical elements disposed along an exterior of the optical housing. The optical housing may also a plurality of sections defined within the interior of the optical housing. Each of the optical sections may be associated with a separate light source of the plurality of light sources and a separate optical element of the plurality of optical elements.

Abstract: A system comprising a cryogenic storage tank for storing cryogen, a pump in fluid communication with the cryogenic storage tank for pumping cryogen from the cryogenic storage tank to a high pressure, an evaporator in fluid communication with the pump for evaporating the high-pressure cryogen from the pump to form a high-pressure gas, a power recovery apparatus comprising a drive shaft for transmitting mechanical power, and an electrical machine mechanically coupled to the drive shaft of the power recovery apparatus for converting the mechanical power recovered by the power recovery apparatus into electrical energy. The system is operable in a power recovery mode in which the power recovery apparatus is driven by and recovers mechanical power from high-pressure gas supplied by the evaporator, and a motored mode in which the power recovery apparatus is driven by a driving means other than high-pressure gas supplied by the evaporator.

Abstract: Multi-function lighting fixtures are provided. In one example implementation, a lighting fixture may include an optical housing extending lengthwise between a first end and a second end. The optical housing may include a plurality of light sources disposed within an interior of the optical housing and a plurality of optical elements disposed along an exterior of the optical housing. The optical housing may also a plurality of compartments defined within the interior of the optical housing. Each of the optical compartments may be associated with a separate light source of the plurality of light sources and a separate optical element of the plurality of optical elements.

Abstract: A ceiling mounted light fixture includes a lens assembly including a central lens and a pair of side lenses. The central lens extends along a longitudinal axis, and each side lens extends parallel to the central lens and is positioned on a lateral side of the central lens. The fixture further includes at least one central light emitter for emitting light directly through the central lens and a pair of side light emitters. At least one control component operatively connected to the central light emitter and the side light emitters is configured to operate in a first mode in which the central light emitter is deactivated and the side light emitters are activated, and a second mode in which the central light emitter and the side light emitters are activated.

Abstract: Provided are variants of a chimeric anti-EGFR antibody. In various embodiments, the variants exhibit substantially improved thermostabilities and/or substantially higher levels of humanness, while retaining binding affinity near the parental level. The consistently high quality of the turnkey CoDAH designs, over a whole panel of variants, suggests that a computationally-directed approach encapsulates key determinants of antibody structure and function.

Abstract: Apparatus, systems, and methods for controlling light output in a lighting system based on defined light profiles are provided. In one example implementation, a light fixture can include a first light emitting diode (LED) array having one or more LED light sources and a second LED array having one or more LED light sources. The light fixture can include a power circuit configured to provide power to the first LED array and the second LED array according to a power distribution among the first LED array and the second LED array. The light fixture can include one or more control devices configured to control the power circuit to adjust the power distribution among the first LED array and the second LED array based at least in part on a signal indicative of a real time clock and a defined light profile associated with a user identified to be present in a space illuminated by the light fixture.

Abstract: Compositions comprising deimmunized lysostaphin and methods of using the same, e.g., to treat microbial infection in or on a subject, are provided.

Abstract: A cryogenic energy storage system comprising a liquefaction apparatus for liquefying a gas to form a cryogen, wherein the liquefaction apparatus is controllable to draw power from an external power source to liquefy the gas, a cryogenic storage tank in fluid communication with the liquefaction apparatus for storing cryogen produced by the liquefaction apparatus, a power recovery apparatus in fluid communication with the cryogenic storage tank for recovering power from cryogen from the cryogenic storage tank by heating the cryogen to form a gas and expanding said gas, a hot thermal store for storing hot thermal energy, wherein the hot thermal store and the power recovery apparatus are arranged so that hot thermal energy from the hot thermal store can be transferred to the gas before and/or during expansion in the power recovery apparatus, and a charging apparatus which is controllable to draw power from the external power source when the power drawn by the liquefaction apparatus is below a threshold value, and

Abstract: Apparatus, systems, and methods for controlling light output in a lighting system based on defined light profiles are provided. In one example implementation, a light fixture can include a first light emitting diode (LED) array having one or more LED light sources and a second LED array having one or more LED light sources. The light fixture can include a power circuit configured to provide power to the first LED array and the second LED array according to a power distribution among the first LED array and the second LED array. The light fixture can include one or more control devices configured to control the power circuit to adjust the power distribution among the first LED array and the second LED array based at least in part on a signal indicative of a real time clock and a defined light profile associated with a user identified to be present in a space illuminated by the light fixture.

Abstract: A system comprising a cryogenic storage tank for storing cryogen, a pump in fluid communication with the cryogenic storage tank for pumping cryogen from the cryogenic storage tank to a high pressure, an evaporator in fluid communication with the pump for evaporating the high-pressure cryogen from the pump to form a high-pressure gas, a power recovery apparatus comprising a drive shaft for transmitting mechanical power, and an electrical machine mechanically coupled to the drive shaft of the power recovery apparatus for converting the mechanical power recovered by the power recovery apparatus into electrical energy. The system is operable in a power recovery mode in which the power recovery apparatus is driven by and recovers mechanical power from high-pressure gas supplied by the evaporator, and a motored mode in which the power recovery apparatus is driven by a driving means other than high-pressure gas supplied by the evaporator.

Abstract: Compositions comprising deimmunized lysostaphin and methods of using the same, e.g., to treat microbial infection in or on a subject, are provided.

Abstract: Apparatus, systems, and methods for controlling light output in a lighting system based on defined light profiles are provided. In one example implementation, a light fixture can include a first light emitting diode (LED) array having one or more LED light sources and a second LED array having one or more LED light sources. The light fixture can include a power circuit configured to provide power to the first LED array and the second LED array according to a power distribution among the first LED array and the second LED array. The light fixture can include one or more control devices configured to control the power circuit to adjust the power distribution among the first LED array and the second LED array based at least in part on a signal indicative of a real time clock and a defined light profile associated with a user identified to be present in a space illuminated by the light fixture.