Abstract: Real time, on demand rendered image delivery may be provided using one or more local image servers, image stores corresponding to the local image servers, one or more rendering servers, and a global image store. When a request for an image of three dimensional object is provided to a local image server, that server may respond to the request by determining if is present in its corresponding local image store. If it is not, then the local image server may obtain the image, store it in its corresponding local image store, and then return it. The one or more rendering servers may respond to messages indicating that one or the local image servers are obtaining an image by generating that image based on rendering it using special purpose rendering hardware, storing it in the global image store, and sending a completion message indicating that the requested image had been generated.

Abstract: Real time, on demand rendered image delivery may be provided using one or more local image servers, image stores corresponding to the local image servers, one or more rendering servers, and a global image store. When a request for an image of three dimensional object is provided to a local image server, that server may respond to the request by determining if is present in its corresponding local image store. If it is not, then the local image server may obtain the image, store it in its corresponding local image store, and then return it. The one or more rendering servers may respond to messages indicating that one or the local image servers are obtaining an image by generating that image based on rendering it using special purpose rendering hardware, storing it in the global image store, and sending a completion message indicating that the requested image had been generated.

Abstract: The present invention relates to methods for identifying among the genes that are down-regulated in cells or tissues having disease including cancer, the CpG sites within the CpG islands of said genes, wherein the identified CpG sites show great potential for diagnostic utility. In another aspect, the present invention also provides methods of using the selected CpG sites for purposes of diagnosis, prognosis, staging, assessing or monitoring the therapy of or recovery from a disease such as cancer.

Abstract: Provided is a method for determining genomic imprinting disorders in a patient based upon methylation specific primer extension in a format amenable to high throughput and multiplex formats. After bisulfite modification of a genomic sample, DNA is amplified and hybridized to discrimination primers specific for a CpG dinucleotide site in the sample. Because no extension products from the discrimination primers are produced from DNA that has a deletion or functional inactivation at the CpG site, the sample may be diagnosed as having a genomic imprinting disorder by way of comparison with a normal sample.

Abstract: The present invention relates to methods for identifying among the genes that are down-regulated in cells or tissues having disease including cancer, the CpG sites within the CpG islands of said genes, wherein the identified CpG sites show great potential for diagnostic utility. In another aspect, the present invention also provides methods of using the selected CpG sites for purposes of diagnosis, prognosis, staging, assessing or monitoring the therapy of or recovery from a disease such as cancer.

Abstract: The present invention relates to methods for identifying among the genes that are down-regulated in cells or tissues having disease including cancer, the CpG sites within the CpG islands of said genes, wherein the identified CpG sites show great potential for diagnostic utility. In another aspect, the present invention also provides methods of using the selected CpG sites for purposes of diagnosis, prognosis, staging, assessing or monitoring the therapy of or recovery from a disease such as cancer.