Abstract: A moulded polymer article having a monolithic wall part composed of a polymer, the monolithic wall part having a core layer of expanded cellular foam, composed of the polymer, disposed between, and integral with, first and second solid skins, composed of the polymer, wherein the core layer is multilaminar and includes a first layer of the expanded cellular foam adjacent to the first solid skin, a second layer of the expanded cellular foam adjacent to the second solid skin, and an intermediate layer of the expanded cellular foam which is between, and adjacent to, the first and second layers, wherein the first and second layers have a first cellular microstructure of closed cells and the intermediate layer has a second cellular microstructure of cells which have an average aspect ratio between a maximum cell dimension and a minimum cell dimension which is greater than 2:1 and less than 5:1 and wherein in the second cellular microstructure the maximum cell dimension of the cells is oriented in a direction extend

Abstract: A container having an annular sidewall with upper and lower annular peripheral edges and a lattice structure of elongate ribs interconnecting the upper and lower annular peripheral edges, wherein the lattice structure is an open framework defining a plurality of sidewall openings, and a base having an annular peripheral edge which is integral with the lower annular peripheral edge of the sidewall, the annular peripheral edge of the base surrounding a base wall structure which is integral therewith, the base wall structure having at least one injection moulding sprue at a central region of the base wall structure, wherein the at least one injection moulding sprue is connected to the upper annular peripheral edge of the annular sidewall by the base wall structure, the annular peripheral edge of the base, the lower annular peripheral edge of the sidewall and the lattice structure of the sidewall, wherein the sidewall and the base are composed of a thermoplastic polymer and define a central concavity for packagin

Abstract: A tray having: an annular sidewall having upper and lower annular peripheral edges, an upper annular peripheral rim which is integral with the upper annular peripheral edge, and a base having an annular peripheral edge which is integral with the lower annular peripheral edge of the sidewall, wherein the rim, the sidewall and the base are composed of a thermoplastic polymer and the sidewall and the base define a central concavity for packaging a product, wherein the base has a lattice structure of elongate foam ribs interconnected by foam junctions, wherein each foam rib has opposite ends, and each end is integrally connected to either the annular peripheral edge of the base or one of the foam junctions, wherein each foam rib and each foam junction has opposed upper and lower unfoamed solid skins of the thermoplastic polymer on opposite sides of a central cellular foam core of the thermoplastic polymer.

Abstract: The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. In addition, the disclosure describes aptamer constructs that include a variety of functionalities, including a cleavable element, a detection element, and a capture or immobilization element.

Abstract: An intermediate article for assembly to form a container, the intermediate article having a base which is polygonal in plan and having an annular peripheral edge with a plurality of edge portions surrounding a base wall structure, a plurality of wall elements around the base, each wall element being adjacent to a respective edge portion of the polygonal base, wherein each wall element has a pair of opposite outwardly extending edges having a sidewall structure therebetween, each outwardly extending edge comprising at least one member of a respective fixing mechanism for affixing adjacent outwardly extending edges of adjacent wall elements, wherein the sidewall and the base are composed of an injection moulded thermoplastic polymer, and a flexible sheet having a central part which is bonded to the base wall structure and a plurality of extending parts, each extending part being connected to, and extending away from, the central part, each extending part being bonded to the sidewall structure of a respective wa

Abstract: A container having an annular sidewall with upper and lower annular peripheral edges and a lattice structure of elongate ribs interconnecting the upper and lower annular peripheral edges, wherein the lattice structure is an open framework defining a plurality of sidewall openings, and a base having an annular peripheral edge which is integral with the lower annular peripheral edge of the sidewall, the annular peripheral edge of the base surrounding a base wall structure which is integral therewith, the base wall structure having at least one injection moulding sprue at a central region of the base wall structure, wherein the at least one injection moulding sprue is connected to the upper annular peripheral edge of the annular sidewall by the base wall structure, the annular peripheral edge of the base, the lower annular peripheral edge of the sidewall and the lattice structure of the sidewall, wherein the sidewall and the base are composed of a thermoplastic polymer and define a central concavity for packagin

Abstract: A tray having: an annular sidewall having upper and lower annular peripheral edges, an upper annular peripheral rim which is integral with the upper annular peripheral edge, and a base having an annular peripheral edge which is integral with the lower annular peripheral edge of the sidewall, wherein the rim, the sidewall and the base are composed of a thermoplastic polymer and the sidewall and the base define a central concavity for packaging a product, wherein the base has a lattice structure of elongate foam ribs interconnected by foam junctions, wherein each foam rib has opposite ends, and each end is integrally connected to either the annular peripheral edge of the base or one of the foam junctions, wherein each foam rib and each foam junction has opposed upper and lower unfoamed solid skins of the thermoplastic polymer on opposite sides of a central cellular foam core of the thermoplastic polymer

Abstract: Methods of forming an article from a molten plastic composition comprising a polymer and a blowing agent. The methods include injecting the molten plastic composition into a mould, allowing the plastic composition to form a first solid skin adjacent to an in contact with a first cavity-forming surface of the mould and a second solid skin adjacent to and in contact with a second cavity-forming surface of the mould, and then opening the mould before the molten plastic composition between the first and second solid skins in at least one portion of the circumference of a region of the mould cavity defining an annular cross-section of the cavity has solidified.

Abstract: The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. In addition, the disclosure describes aptamer constructs that include a variety of functionalities, including a cleavable element, a detection element, and a capture or immobilization element.

Abstract: The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. In addition, the disclosure describes aptamer constructs that include a variety of functionalities, including a cleavable element, a detection element, and a capture or immobilization element.

Abstract: Methods of forming an article from a molten plastic composition comprising a polymer and a blowing agent. The methods include injecting the molten plastic composition into a mould, allowing the plastic composition to form a first solid skin adjacent to an in contact with a first cavity-forming surface of the mould and a second solid skin adjacent to and in contact with a second cavity-forming surface of the mould, and then opening the mould before the molten plastic composition between the first and second solid skins in at least one portion of the circumference of a region of the mould cavity defining an annular cross-section of the cavity has solidified.

Abstract: Methods of forming an article from a molten plastic composition comprising a polymer and a blowing agent. The methods include injecting the molten plastic composition into a mould, allowing the plastic composition to form a first solid skin adjacent to an in contact with a first cavity-forming surface of the mould and a second solid skin adjacent to and in contact with a second cavity-forming surface of the mould, and then opening the mould before the molten plastic composition between the first and second solid skins in at least one portion of the circumference of a region of the mould cavity defining an annular cross-section of the cavity has solidified.

Abstract: The present invention provides aptamers that specifically bind to the EGF receptor in a sample, and diagnostic and analytical methods using those aptamers. In some embodiments, the aptamers include a 3? cap. In some embodiments, the 3? cap is an inverted deoxythymidine. In some embodiments the aptamers include a spacer and at least one moiety selected from the group consisting of binding pair member and a detectable label, wherein the spacer is attached to the 5?-end of the aptamer and the moiety is attached the 5? end of the spacer. In some embodiments the spacer is hexaethylene glycol. In some embodiments, the binding pair member biotin. In some embodiments the detectable label is a fluorophore.

Abstract: The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. In addition, the disclosure describes aptamer constructs that include a variety of functionalities, including a cleavable element, a detection element, and a capture or immobilization element.

Abstract: The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. In addition, the disclosure describes aptamer constructs that include a variety of functionalities, including a cleavable element, a detection element, and a capture or immobilization element.

Abstract: The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. In addition, the disclosure describes aptamer constructs that include a variety of functionalities, including a cleavable element, a detection element, and a capture or immobilization element.

Abstract: The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. In addition, the disclosure describes aptamer constructs that include a variety of functionalities, including a cleavable element, a detection element, and a capture or immobilization element.

Abstract: The present invention provides aptamers that specifically bind to the EGF receptor in a sample, and diagnostic and analytical methods using those aptamers. In some embodiments, the aptamers include a 3? cap. In some embodiments, the 3? cap is an inverted deoxythymidine. In some embodiments the aptamers include a spacer and at least one moiety selected from the group consisting of binding pair member and a detectable label, wherein the spacer is attached to the 5?-end of the aptamer and the moiety is attached the 5? end of the spacer. In some embodiments the spacer is hexaethylene glycol. In some embodiments, the binding pair member biotin. In some embodiments the detectable label is a fluorophore.

Abstract: The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. In addition, the disclosure describes aptamer constructs that include a variety of functionalities, including a cleavable element, a detection element, and a capture or immobilization element.

Abstract: The present invention provides aptamers that specifically bind to the EGF receptor in a sample, and diagnostic and analytical methods using those aptamers. In some embodiments, the aptamers include a 3? cap. In some embodiments, the 3? cap is an inverted deoxythymidine. In some embodiments the aptamers include a spacer and at least one moiety selected from the group consisting of binding pair member and a detectable label, wherein the spacer is attached to the 5?-end of the aptamer and the moiety is attached the 5? end of the spacer. In some embodiments the spacer is hexaethylene glycol. In some embodiments, the binding pair member biotin. In some embodiments the detectable label is a fluorophore.