Patents by Inventor Chris Broka

Chris Broka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases
    Publication number: 20070049609
    Abstract: Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
    Type: Application
    Filed: August 25, 2006
    Publication date: March 1, 2007
    Inventors: Chris Broka, David Carter, Michael Dillon, Anthony Ford, Ronald Hawley, Alam Jahangir, Amy Moore, Daniel Parish
  • Indole derivatives as anti-inflammatory agents
    Publication number: 20060178420
    Abstract: This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH2—, —O—, —S—, or —S(O)—; and the other substituents are as defined in the specification; or individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: March 2, 2006
    Publication date: August 10, 2006
    Inventors: Chris Broka, Jeffrey Campbell
  • Quinoline derivatives as anti-inflammatory agents
    Publication number: 20060084677
    Abstract: This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a CH2, CH(OH), C(O), C?NOR4, NR5, O, S, S(O), or S(O)2, and the other substituents are as defined in the specification; or prodrugs, individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: November 30, 2005
    Publication date: April 20, 2006
    Inventors: Chris Broka, Woongki Kim, David Smith, Kevin McLaren
  • Diaminopyrimidines as P2X3 and P2X2/3 antagonists
    Publication number: 20050209260
    Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
    Type: Application
    Filed: March 3, 2005
    Publication date: September 22, 2005
    Inventors: Chris Broka, David Carter, Michael Dillon, Ronald Hawley, Alam Jahangir, Clara Lin, Daniel Parish
  • Indole derivatives as anti-inflammatory agents
    Publication number: 20050176803
    Abstract: This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH2—, —O—, —S—, or —S(O)—; and the other substituents are as defined in the specification; or individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: February 25, 2005
    Publication date: August 11, 2005
    Inventors: Chris Broka, Jeffrey Campbell
  • Chemotherapeutic maleimides
    Patent number: 5405864
    Abstract: Maleimide derivatives, i.e., the compounds of Formula I: ##STR1## wherein: R.sup.1 is H, halo, alkyl, OH, alkoxy, haloalkyl, NO.sub.2, or NR.sup.5 R.sup.6 ;R.sup.2 is H or CN;R.sup.3 is aryl or heteroaryl, provided that R.sup.3 is heteroaryl when R.sup.2 is H and R.sup.4 is NR.sup.5 R.sup.6 ; andR.sup.4 is NR.sup.5 R.sup.6 or isothiourea,where R.sup.5 and R.sup.6 are independently H or lower alkyl;and the pharmaceutically acceptable salts thereof, and their use as chemotherapeutic agents.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: April 11, 1995
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Chris A. Broka