Abstract: A needle-free injector including dose setting apparatus. The needle-free injector includes a hammer housing, a mainspring positioned within the hammer housing, and a hammer assembly engaged with the mainspring. The hammer assembly may include a hammer sleeve and a hammer engaged with the hammer sleeve, where the engagement between the hammer sleeve and the hammer provides for a forward or rearward position of the hammer with respect to the hammer sleeve be changed to select an injection dose from two or more available injection doses. Additional embodiments include methods of varying or setting the dose delivered by a needle-free injector.

Abstract: A needle-free injection device including an outer housing, and an inner housing. The inner housing is moveable within the outer housing between a syringe loading position and a firing position. The needle-free injection device also includes a syringe mount to receive a needle-free syringe at one end of the inner housing. The syringe mount includes an interlocking structure cooperating with the inner housing and outer housing to prevent placement of the needle-free syringe into engagement with the syringe mount unless the inner housing is in the syringe loading position.

Abstract: A needle-free injection device including an outer housing and an inner housing configured to receive a needle-free syringe in one end. The inner housing of the device is moveable within the outer housing between a syringe loading position and a firing position. The device also includes an activation button and a housing lock engaged by the activation button to prohibit movement of the inner housing from the syringe loading position to the firing position if the activation button is activated in the syringe loading position.

Abstract: A needle-free injection device suitable for delivering a therapeutic substance into the intradermal space of a patient. The needle-free injection device includes a first handle positioned to pivot between an open position and a closed position, a main spring, and a hammer engaged with the main spring. The needle-free injection device also includes a return sleeve engaged with the hammer when the first handle is in the open position. The return sleeve is disengaged with the hammer when the first handle is in the closed position. Needle-free injection systems and methods of operating a needle-free injection device are also disclosed.

Abstract: A needle-free injection device suitable for delivering a therapeutic substance into the intradermal space of a patient. The needle-free injection device includes an injector body defining a syringe end. The device also includes a first handle attached with a hinge to the injector body such that the first handle pivots between an open and a closed position and remains attached to the injector body during an injection, a main spring positioned within the injector body, a return sleeve engaged with the main spring, and a first linkage between the first handle and the return sleeve. The first linkage causes the return sleeve to move away from the syringe end of the injector body when the first handle is moved from the open position to the closed position, thereby compressing the main spring. Needle-free injection systems and methods of operating a needle-free injection device are also disclosed.

Abstract: Embodiments disclosed herein include needle-free syringe and cap assemblies and filling tub systems. One embodiment of filling tub system includes a filling tub having exterior walls and a floor. The floor is formed into a plurality of sockets configured to receive and support a plurality of cap and syringe body assemblies, with each cap and syringe assembly received in a separate socket. Furthermore, each socket is configured to receive and support a syringe and cap assembly with contact only between one or more surfaces of the socket and selected outer surfaces of the cap. Methods of pre-filling a quantity of needle-free syringes are also disclosed.

Abstract: A needle-free injection device including an outer housing and an inner housing configured to receive a needle-free syringe in one end. The inner housing of the device is moveable within the outer housing between a syringe loading position and a firing position. The device also includes an activation button and a housing lock engaged by the activation button to prohibit movement of the inner housing from the syringe loading position to the firing position if the activation button is activated in the syringe loading position.

Abstract: Methods of operating needle-free injection device having an outer housing and an inner housing is disclosed. The inner housing is configured to receive a needle-free syringe in one end. In addition, the inner housing is movable within the outer housing between a syringe loading position and a firing position. The device may include an activation button operatively associated with the inner and outer housings and a housing lock engaged by the activation button to prohibit movement of the inner housing from the syringe loading position to the firing position when the activation button is activated with the inner housing in the syringe loading position.

Abstract: A needle-free injection device suitable for delivering a therapeutic substance into the intradermal space of a patient. The needle-free injection device includes an injector body defining a syringe end. The device also includes a first handle attached with a hinge to the injector body such that the first handle pivots between an open and a closed position and remains attached to the injector body during an injection, a main spring positioned within the injector body, a return sleeve engaged with the main spring, and a first linkage between the first handle and the return sleeve. The first linkage causes the return sleeve to move away from the syringe end of the injector body when the first handle is moved from the open position to the closed position, thereby compressing the main spring. Needle-free injection systems and methods of operating a needle-free injection device are also disclosed.

Abstract: A needle-free injection device suitable for delivering a therapeutic substance into the intradermal space of a patient. The needle-free injection device includes an injector body defining a syringe end. The device also includes a first handle attached with a hinge to the injector body such that the first handle pivots between an open and a closed position and remains attached to the injector body during an injection, a main spring positioned within the injector body, a return sleeve engaged with the main spring, and a first linkage between the first handle and the return sleeve. The first linkage causes the return sleeve to move away from the syringe end of the injector body when the first handle is moved from the open position to the closed position, thereby compressing the main spring. Needle-free injection systems and methods of operating a needle-free injection device are also disclosed.

Abstract: Embodiments disclosed herein include needle-free syringe and cap assemblies and filling tub systems. One embodiment of filling tub system includes a filling tub having exterior walls and a floor. The floor is formed into a plurality of sockets configured to receive and support a plurality of cap and syringe body assemblies, with each cap and syringe assembly received in a separate socket. Furthermore, each socket is configured to receive and support a syringe and cap assembly with contact only between one or more surfaces of the socket and selected outer surfaces of the cap. Methods of pre-filling a quantity of needle-free syringes are also disclosed.

Abstract: Embodiments disclosed herein include needle-free syringe and cap assemblies and filling tub systems. One embodiment of filling tub system includes a filling tub having exterior walls and a floor. The floor is formed into a plurality of sockets configured to receive and support a plurality of cap and syringe body assemblies, with each cap and syringe assembly received in a separate socket. Furthermore, each socket is configured to receive and support a syringe and cap assembly with contact only between one or more surfaces of the socket and selected outer surfaces of the cap. Methods of pre-filling a quantity of needle-free syringes are also disclosed.

Abstract: Embodiments disclosed herein include needle-free syringe and cap assemblies and filling tub systems. One embodiment of filling tub system includes a filling tub having exterior walls and a floor. The floor is formed into a plurality of sockets configured to receive and support a plurality of cap and syringe body assemblies, with each cap and syringe assembly received in a separate socket. Furthermore, each socket is configured to receive and support a syringe and cap assembly with contact only between one or more surfaces of the socket and selected outer surfaces of the cap. Methods of pre-filling a quantity of needle-free syringes are also disclosed.

Abstract: A needle-free injection device suitable for delivering a therapeutic substance into the intradermal space of a patient. The needle-free injection device includes an injector body defining a syringe end. The device also includes a first handle attached with a hinge to the injector body such that the first handle pivots between an open and a closed position and remains attached to the injector body during an injection, a main spring positioned within the injector body, a return sleeve engaged with the main spring, and a first linkage between the first handle and the return sleeve. The first linkage causes the return sleeve to move away from the syringe end of the injector body when the first handle is moved from the open position to the closed position, thereby compressing the main spring. Needle-free injection systems and methods of operating a needle-free injection device are also disclosed.

Abstract: A needle-free injection device suitable for delivering a therapeutic substance into the intradermal space of a patient. The needle-free injection device includes a main spring which can be compressed using one or more handles attached to the device to place the needle-free injection device into an armed configuration. Device embodiments may optionally include an injector tube and associated apparatus which may be moved relative to other device structures when the injector is pressed against the skin of a patient with sufficient force. The disclosed operational switches and release mechanisms cooperate to prevent injection unless the device is properly positioned for an injection. Needle-free injection systems and methods of operating a needle-free injection device are also disclosed.

Abstract: Methods of operating needle-free injection device having an outer housing and an inner housing is disclosed. The inner housing is configured to receive a needle-free syringe in one end. In addition, the inner housing is movable within the outer housing between a syringe loading position and a firing position. The device may include an activation button operatively associated with the inner and outer housings and a housing lock engaged by the activation button to prohibit movement of the inner housing from the syringe loading position to the firing position when the activation button is activated with the inner housing in the syringe loading position.

Abstract: A needle-free injection device suitable for delivering a therapeutic substance into the intradermal space of a patient. The needle-free injection device includes a main spring which can be compressed using one or more handles attached to the device to place the needle-free injection device into an armed configuration. Device embodiments may optionally include an injector tube and associated apparatus which may be moved relative to other device structures when the injector is pressed against the skin of a patient with sufficient force. The disclosed operational switches and release mechanisms cooperate to prevent injection unless the device is properly positioned for an injection. Needle-free injection systems and methods of operating a needle-free injection device are also disclosed.

Abstract: A needle-free injection device suitable for delivering a therapeutic substance into the intradermal space of a patient. The needle-free injection device includes a main spring which can be compressed using one or more handles attached to the device to place the needle-free injection device into an armed configuration. Device embodiments may optionally include an injector tube and associated apparatus which may be moved relative to other device structures when the injector is pressed against the skin of a patient with sufficient force. The disclosed operational switches and release mechanisms cooperate to prevent injection unless the device is properly positioned for an injection. Needle-free injection systems and methods of operating a needle-free injection device are also disclosed.

Abstract: A needle-free injection device having an outer housing and an inner housing is disclosed. The inner housing is configured to receive a needle-free syringe in one end. In addition, the inner housing is movable within the outer housing between a syringe loading position and a firing position. The device also includes an activation button operatively associated with the inner and outer housings and a housing lock engaged by the activation button to prohibit movement of the inner housing from the syringe loading position to the firing position when the activation button is activated with the inner housing in the syringe loading position. Methods and apparatus for using, filing and operating the needle-free injection device are also disclosed.

Abstract: A vial adapter for a needle-free injection syringe and methods of filling a needle-free syringe from a vial of injectable fluid. One vial adapter embodiment includes a housing and a compliant valve. The housing includes a central divider located between a vial opening and a needle-free syringe opening. The housing also includes a hollow center post extending from the central divider toward the needle-free syringe opening and a hollow filling needle extending from the central divider toward the vial opening. Together, the filling needle and center post provide for fluid communication between the vial opening and the needle-free syringe opening. The compliant valve includes a surface forming a fluid tight seal with the central divider and an inner passageway. In addition, a syringe sealing surface provides for a fluid tight seal with a needle-free syringe placed into contact with the compliant valve.