Patents by Inventor Chris Castello

Chris Castello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GUANIDINIUM DELIVERY CARRIERS
    Publication number: 20100160210
    Abstract: Disclosed herein are transmembrane transporter compounds containing guanidinium groups. Also disclosed herein are methods for transporting a biologically active moiety across a biological membrane using the transmembrane transporter compounds. Particularly, this invention provides a method for the delivery of a biologically active moiety across the biological membranes of such membranes as endothelial tissues.
    Type: Application
    Filed: February 22, 2010
    Publication date: June 24, 2010
    Applicant: NITTO DENKO CORPORATION
    Inventors: Gang Zhao, Lei Yu, Jian Liu, Chieko Kitaura, Xinghe Wang, Chris Castello
  • Guanidinium delivery carriers
    Patent number: 7687603
    Abstract: Disclosed herein are transmembrane transporter compounds containing guanidinium groups. Also disclosed herein are methods for transporting a biologically active moiety across a biological membrane using the transmembrane transporter compounds. Particularly, this invention provides a method for the delivery of a biologically active moiety across the biological membranes of such membranes as endothelial tissues.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: March 30, 2010
    Assignee: Nitto Denko Corporation
    Inventors: Gang Zhao, Lei Yu, Jian Liu, Chieko Kitaura, Xinghe Wang, Chris Castello
  • Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells
    Publication number: 20070269891
    Abstract: A cell transfection/culture device is disclosed which includes a solid support coated with a degradable polymer cation as a transfection reagent. The transfection/culture device is conveniently stored at room temperature until use. Cell transfection is accomplished easily by adding the nucleic acid of interest and the cells to be transfected to the transfection/culture device. Cell transfection is completed in less than one hour by using the transfection/culture device described herein.
    Type: Application
    Filed: December 14, 2005
    Publication date: November 22, 2007
    Inventors: Yasunobu Tanaka, Chris Castello, Lei Yu
  • Guanidinium delivery carriers
    Publication number: 20070078094
    Abstract: Disclosed herein are transmembrane transporter compounds containing guanidinium groups. Also disclosed herein are methods for transporting a biologically active moiety across a biological membrane using the transmembrane transporter compounds. Particularly, this invention provides a method for the delivery of a biologically active moiety across the biological membranes of such membranes as endothelial tissues.
    Type: Application
    Filed: September 22, 2006
    Publication date: April 5, 2007
    Inventors: Gang Zhao, Lei Yu, Jian Liu, Chieko Kitaura, Xinghe Wang, Chris Castello
  • Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells
    Publication number: 20060134790
    Abstract: A cell transfection/culture device is disclosed which includes a solid support coated with a degradable polymer cation as a transfection reagent. The transfection/culture device is conveniently stored at room temperature until use. Cell transfection is accomplished easily by adding the nucleic acid of interest and the cells to be transfected to the transfection/culture device. Cell transfection is completed in less than one hour by using the transfection/culture device described herein.
    Type: Application
    Filed: December 14, 2005
    Publication date: June 22, 2006
    Inventors: Yasunobu Tanaka, Chris Castello, Lei Yu
  • Cationic polymers having degradable crosslinks
    Publication number: 20050089503
    Abstract: A synthetic polymer comprises a cationic recurring unit and a crosslinking unit, wherein the crosslinking unit comprises at least a first degradable unit (preferably acid-labile) and at least a second degradable unit (preferably hydrolyzable). A carrier composition comprising the synthetic polymer and a bioactive agent is useful for the delivery of the bioactive agent into the nuclei of the cells.
    Type: Application
    Filed: October 24, 2003
    Publication date: April 28, 2005
    Inventors: Sheng Li, Chris Castello, Sang Van
  • Methods for extending amorphous photorefractive material lifetimes
    Publication number: 20040242841
    Abstract: Methods for significantly improving the working lifetime of photorefractive materials and photorefractive articles involve annealing the photorefractive materials at a temperature higher than the temperature range in which degradation occurs. The methods are particularly applicable to amorphous photorefractive materials and devices in which phase separation results in performance degradation or device failure.
    Type: Application
    Filed: March 15, 2004
    Publication date: December 2, 2004
    Inventors: J. Kevin Cammack, Chris Castello, Peng Wang