Abstract: A system may include one or more memory devices storing instructions thereon that, when executed by one or more processors, cause the one or more processors to detect a transmission of a first data packet between a computing device and a server, determine a first amount of time elapsed between the transmission of the first data packet and a transmission of a second data packet, store the first amount of time in a data structure in a database, detect a transmission of a third data packet between the computing device and the server, determine a second amount of time elapsed between the transmission of the second data packet and the transmission of the third data packet, and determine that the computing device is utilizing a proxy device to communicate with the server.

Abstract: Systems and methods for conducting payment network-less transactions are disclosed. A method may include: receiving, by a computer application executed on an electronic device, payment card information for a payment card; receiving by the computer application, a rule for the payment card from an issuer backend, the issuer backend associated with an issuer of the payment card; communicating, by the computer application and to a merchant point-of-sale device, an indication that a transaction for a good or service will be conducted without using a payment network; receiving, by the computer application and from the merchant point-of-sale device, transaction details for the transaction; decisioning, by the computer application, the transaction by applying the rule to the transaction details; communicating, by the computer application, approval to the merchant point-of-sale device in response to approving the transaction; and sending, by the computer application, payment advice to the issuer backend.

Abstract: Systems and methods for network-based delivery of dynamic content are disclosed. A method may include: receiving, by a network computer program, a location for a customer electronic device associated with a customer; determining, by the network computer program and from the location, that the customer is within a predetermined distance of a merchant; requesting, by the network computer program, content for one or more payment card issued by an issuer to the customer from an issuer backend for the issuer; receiving, by the network computer program, the content; and communicating, by the network computer program, the content to a merchant backend for the merchant. The merchant backend receives, from a merchant point of sale device, payment card information for one of the payment cards, retrieves the content for the payment card, and causes the merchant point of sale device to display the content on a display.

Abstract: Disclosed is a system comprising a vehicle, a trailer, and a display screen. The system includes a trailer angle between a centerline of the vehicle and a centerline of the trailer. At least one time step after the vehicle is driven backward such that the trailer angle increases beyond a threshold value, a steering warning icon is displayed on the display screen. When the trailer angle decreases below the threshold value, the steering warning icon is removed from the display screen.

Abstract: Disclosed is a system comprising a vehicle, a trailer, and a display screen. The system includes a trailer angle between a centerline of the vehicle and a centerline of the trailer. At least one time step after the vehicle is driven backward such that the trailer angle increases beyond a threshold value, a steering warning icon is displayed on the display screen. When the trailer angle decreases below the threshold value, the steering warning icon is removed from the display screen.

Abstract: In an embodiment, a vehicle makes a determination, during a second ignition-on cycle of the vehicle, that a trailer brake output circuit of the vehicle was operated during a first ignition-on cycle of the vehicle preceding the second ignition-on cycle. In response to making the determination, the vehicle presents a query, via a user interface of the vehicle, whether to operate the trailer brake output circuit according to a previously-used trailer profile according to which the trailer brake output circuit was operated during the first ignition-on cycle preceding the second ignition-on cycle. The vehicle receives a reply, associated with the query, via the user interface and, in response to receiving the reply, operates the trailer brake output circuit based on the reply.

Abstract: The present invention relates to methods for treating cancer with apilimod and related compositions and methods.

Abstract: The present disclosure relates to methods for treating renal cancer with apilimod and related compositions and methods.

Abstract: In an embodiment, a vehicle makes a determination, during a second ignition-on cycle of the vehicle, that a trailer brake output circuit of the vehicle was operated during a first ignition-on cycle of the vehicle preceding the second ignition-on cycle. In response to making the determination, the vehicle presents a query, via a user interface of the vehicle, whether to operate the trailer brake output circuit according to a previously-used trailer profile according to which the trailer brake output circuit was operated during the first ignition-on cycle preceding the second ignition-on cycle. The vehicle receives a reply, associated with the query, via the user interface and, in response to receiving the reply, operates the trailer brake output circuit based on the reply.

Abstract: The present invention relates to compositions containing a PIKfyve inhibitor, preferably apilimod, APY0201 or YM-201636, most preferably apilimod, for use in treating or preventing viral infections, preferably Ebola or Marburg virus infections. It also relates to a pharmaceutical pack or kit comprising apilimod and at least one additional anti-viral agent.

Abstract: The present invention relates to the use of PIKfyve inhibitors to treat Niemann-Pick disease type C, and related compositions and methods.

Abstract: The present disclosure relates to methods for treating renal cancer with apilimod and related compositions and methods.

Abstract: The present invention relates to methods for treating melanoma with apilimod and related compositions and methods.

Abstract: The present invention relates to methods for treating cancer with apilimod and related compositions and methods.

Abstract: The present invention relates to compositions containing a PIKfyve inhibitor, preferably apilimod, APY0201 or YM-201636, most preferably apilimod, for use in treating or preventing viral infections, preferably Ebola or Marburg virus infections. It also relates to a pharmaceutical pack or kit comprising apillimod and at least one additional anti-viral agent.

Abstract: The present disclosure relates to methods for treating Alzheimer's disease with apilimod and related compositions and methods.

Abstract: The present invention relates to methods for treating cancer with apilimod and related compositions and methods.

Abstract: The present invention relates to methods for treating colorectal cancer with apilimod and related compositions and methods.

Abstract: The present disclosure relates to methods for treating renal cancer with apilimod and related compositions and methods.

Abstract: The present invention relates to methods for treating cancer with apilimod and related compositions and methods.