Abstract: A method for applying a fast curing epoxy traffic marking composition is provided in which curing agents are coated on a carrier such as glass beads or porous silica. These carriers are dropped onto the epoxy coating and promote rapid curing of the top layer of the epoxy coating while the bottom layer is given additional time to adhere to the roadway surface. This enables the application contractor to open a marked roadway in a quicker manner with less motorist disruption.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as defined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: The present invention provides a marking system adapted for coating a surface of a substrate in which a drying agent is used. According to a first aspect of the invention, a binder layer, such as paint, is applied to the surface. A drying agent is dispensed into the spray of a binder and becomes incorporated with the binder on the substrate surface. The incorporation of the drying agent into the binder prior to application on the surface provides improved mixing of the drying agent and binder and improved performance. According to a second aspect of the invention, a combination of optical elements and a drying agent are stored in a common hopper and are dispensed into the spray of the binder and become incorporated with the binder on the substrate surface. The mixture of optical elements and drying agent prevents coagulation of the drying agent and the resulting clogging of the dispenser.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: A chunk format for a large-scale, high data throughput router includes a preamble that allows each individual chunk to have clock and data recovery performed before the chunk data is retrieved. The format includes a chunk header that contains information specific to the entire chunk. A chunk according to the present format can contain multiple packet segments, with each segment having its own packet header for packet-specific information. The format provides for a scrambler seed which allows scrambling the data to achieve a favorable zero and one balance as well as minimal run lengths. There can be a random choice of available scrambler seeds for any particular chunk to avoid malicious forcing of zero and one patterns or run lengths of bit zeroes and ones. There are a chunk cyclical redundancy check (CRC) as well as forward error correction (FEC) bytes to detect and/or correct any errors and also to insure a high degree of data and control integrity.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase of the following structural formula: The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

Abstract: The present invention provides a marking system adapted for coating a surface of a substrate in which a drying agent is used. According to a first aspect of the invention, a binder layer, such as paint, is applied to the surface. A drying agent is dispensed into the spray of a binder and becomes incorporated with the binder on the substrate surface. The incorporation of the drying agent into the binder prior to application on the surface provides improved mixing of the drying agent and binder and improved performance. According to a second aspect of the invention, a combination of optical elements and a drying agent are stored in a common hopper and are dispensed into the spray of the binder and become incorporated with the binder on the substrate surface. The mixture of optical elements and drying agent prevents coagulation of the drying agent and the resulting clogging of the dispenser.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: A chunk format for a large-scale, high data throughput router includes a preamble that allows each individual chunk to have clock and data recovery performed before the chunk data is retrieved. The format includes a chunk header that contains information specific to the entire chunk. A chunk according to the present format can contain multiple packet segments, with each segment having its own packet header for packet-specific information. The format provides for a scrambler seed which allows scrambling the data to achieve a favorable zero and one balance as well as minimal run lengths. There are forward error correction (FEC) bytes as well as a chunk cyclical redundancy check (CRC) to detect and/or correct any errors and also to insure a high degree of data and control integrity. Advantageously, a framing symbol inserted into the chunk format itself allows the receiving circuitry to identify or locate a particular chunk format.

Abstract: A patient interface device adapted to provide an interface between a cornea and a surgical laser system. A frame has an applanation end and an attachment end which is adapted to couple to the surgical laser system. A skirt is affixed to the applanation end of the frame and is adapted to seal against the anterior surface of the cornea to form a chamber. A lens is disposed near the applanation end of the frame and is supported by a flexible support which affixes the lens to the frame.