Abstract: Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: Provided herein are compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein Z1, Z2, Z3, R1, R2, R3, and n are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of using a compound of formula (I), or a pharmaceutically acceptable salt thereof, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: Disclosed is an AR self-injection training system and method of use incorporating a marker specifically designed for device-naive self-injection patients. The marker is designed so that it can be removably adhered to an injection site. Once in position it anchors AR content to the injection site for training. The marker is designed to associate AR content to the injection site for training and allows patient to leave the marker in place and inject to the same site. Providing a system that is able to identify a site of injection and to provide salient instructions streamlines the process of training and makes the transition to using a real-device relatively seamless. The provided embodiments can also incorporate error correction functionality and even local anesthesia or analgesic. Following training, the opening in the marker allows patients to leave the marker in place and inject to the same site.

Abstract: An apparatus, including: at least one delivery device (200), each delivery device configured to be either a medicament delivery device or a medicament delivery device trainer, wherein each delivery device includes: a housing (202); a movable component (204) configured to dispense or to simulate dispensing a medicament; and an unpowered electrical circuit (210) having a first lead (212) that is externally accessible, a second lead (216) that is externally accessible, and an electrical loop (218) between the first lead and the second lead and comprising a switch (220). A change in a state of the delivery device either toggles the switch between a closed position and an open position or changes an electrical property of the switch.

Abstract: An apparatus (800), including: an energy harvesting device (102, 804) configured to harvest energy and to convey the harvested energy; a communication device (102, 806); circuitry (104) configured to be powered by the harvested energy and to be in data communication with the communication device; an unpowered indicator (110) configured to exhibit an excursion indicator only when a temperature excursion of a substance (808) has occurred; and a registration sensor (112) configured to be powered by the harvested energy and when so powered and when the excursion indicator is present, to generate a registration of the excursion indicator. When powered by the harvested energy the circuitry is configured to transmit data comprising the registration of the excursion indicator via the communication device.

Abstract: Disclosed is a system for providing personalized self-medication, onboarding, training and improving medication adherence. The system includes a patient computer system comprising at least one processor and at least one memory component: a display, an optional input device, and an optional pointing device, a server connected to the patient computer system by a network link, the server comprising at least one processor and at least one computer readable medium wherein at least one computer readable medium comprises instructions that when executed by at least one processor, cause at least one processor to perform acts comprising: (i) responsive to patient input data, producing a patient personalized assessment; (ii) formulating a customized intervention for the patient based on the patient input data and/or personalized assessment; and (iii) presenting the patient personalized assessment and/or customized intervention on the display.

Abstract: A seat suspension system for a seat of a lightweight vehicle, wherein the system comprises a seat frame to which a seat can be connected, one or more of seat frame mounting bracket mounted to a chassis of the vehicle; one or more mounting feet extending from a front portion of the seat frame and pivotally connectable to the one or more seat frame mounting bracket; a damping assembly mounting bracket mounted to a rear cross member of the seat frame; and a damping device assembly mounted between the chassis of the vehicle and the damping assembly mounting bracket, the damping device assembly structured and operable to dampen the transfer of movement from the chassis of the vehicle to the seat frame.

Abstract: Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: Provided herein are compounds of formula (1): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: A system, device and method for nail care is provided. The nail care system includes a shaping system, a polish removal system and/or a cuticle management system; a vision system; a nail polish application system; and a mobility system. The nail system may further include an accelerated drying system, a hand massage system, a nail identification/diagnosis/estimation of conditions system, an enclosure, a hand/foot rest system, a computer software system, a computer hardware system, a cartridge/pod system, and a multi-tool system. Related apparatuses, techniques and articles are also described.

Abstract: Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: A system, device and method for nail care is provided. The nail care system includes a shaping system, a polish removal system and/or a cuticle management system; a vision system; a nail polish application system; and a mobility system. The nail system may further include an accelerated drying system, a hand massage system, a nail identification/diagnosis/estimation of conditions system, an enclosure, a hand/foot rest system, a computer software system, a computer hardware system, a cartridge/pod system, and a multi-tool system. Related apparatuses, techniques and articles are also described.

Abstract: A system, device and method for nail care is provided. The nail care system includes a shaping system, a polish removal system and/or a cuticle management system; a vision system; a nail polish application system; and a mobility system. The nail system may further include an accelerated drying system, a hand massage system, a nail identification/diagnosis/estimation of conditions system, an enclosure, a hand/foot rest system, a computer software system, a computer hardware system, a cartridge/pod system, and a multi-tool system. Related apparatuses, techniques and articles are also described.

Abstract: A system for counting objects in a queue waiting for service at one of a plurality of electronic points of service “EPOSs” includes an object tracking system and a processor system for processing data. The processor system may have memory means storing data indicative of the positions of each of said EPOSs within a service point area, and be adapted to receive data from each EPOS indicating its operational status and to receive from said tracking system data relating to positions of objects within the service point area. The method of counting objects in a queue comprises firstly determining an initial seed location as a point at which a single queue of objects forms. Then, determining a new seed location as a point at which the single queue forms Once the new seed location is determined, tracked objects may be assigned to the single queue and then counted.

Abstract: There is provided a system and method for secure entry to a property or building. One aspect includes an apparatus having a housing and alarm means for triggering a timed alarm upon removal of a receptacle key from the housing. Locking means is included for locking the housing. Another aspect includes a removable media containing a list of cylinder codes. At least a portion of the list of cylinder codes are transferred to a receptacle key within the housing. Another aspect involves a system having a secure container with locking means for locking a housing. The system includes at least one locking receptacle that is unlocked with the receptacle key. Also provided is a method comprising the steps of retrieving a receptacle key from a secure container, triggering a timed alarm for return of the receptacle key and accessing a locking receptacle with the receptacle key.

Abstract: There is provided a system and method for secure entry to a property or building. One aspect includes an apparatus having a housing and alarm means for triggering a timed alarm upon removal of a receptacle key from the housing. Locking means is included for locking the housing. Another aspect includes a removable media containing a list of cylinder codes. At least a portion of the list of cylinder codes are transferred to a receptacle key within the housing. Another aspect involves a system having a secure container with locking means for locking a housing. The system includes at least one locking receptacle that is unlocked with the receptacle key. Also provided is a method comprising the steps of retrieving a receptacle key from a secure container, triggering a timed alarm for return of the receptacle key and accessing a locking receptacle with the receptacle key.

Abstract: An instrument, article and method are provided for minimizing pain during administration by injection of a liquid, such as, an anesthetic. The instrument has a forward end. A lightpipe mounted freely for vibration projects out of the forward end. The article, a single use tip, is composed of a tip sleeve removably mounted on the forward end of the instrument and a tip member removably mounted on the projecting lightpipe to vibrate a preselected injection site on a human or animal. The tip sleeve and tip member are covered by an elastic overmold that enables the tip member to vibrate freely with respect to the tip sleeve and light from the lightpipe to illuminate the injection site. A vibration unit mounted in the instrument is coupled to the lightpipe. The method is carried out by imparting vibrations and illumination via the lightpipe to the tip member.

Abstract: A system for counting objects in a queue waiting for service at one of a plurality of electronic points of service “EPOSs” includes an object tracking system and a processor system for processing data. The processor system may have memory means storing data indicative of the positions of each of said EPOSs within a service point area, and be adapted to receive data from each EPOS indicating its operational status and to receive from said tracking system data relating to positions of objects within the service point area. The method of counting objects in a queue comprises firstly determining an initial seed location as a point at which a single queue of objects forms. Then, determining a new seed location as a point at which the single queue forms Once the new seed location is determined, tracked objects may be assigned to the single queue and then counted.