Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: A multiple activation-device launching system for a cementing head comprises a launcher body comprising at least one launching chamber and a device chamber, the launching chamber sized to receive one or more activation devices therein, the launching chamber in fluid communication with a power source for launching the activation device into the device chamber. The launching system may further comprise a pressure sensor, a pressure-relief device or a flow-measurement device, or combinations thereof.

Abstract: A multiple activation-device launching system for a cementing head comprises a launcher body and at least one launching chamber that are sized to receive one or more activation devices therein. The activation devices are launched into the principal process-fluid stream inside the cementing head, and may be darts, balls, bombs, canisters and combinations thereof. The launching chambers are in fluid communication with an external power source for launching the activation device into the principal process-fluid stream.

Abstract: A multiple activation-device launching system for a cementing head comprises a launcher body and at least one launching chamber that are sized to receive one or more activation devices therein. The activation devices are launched into the principal process-fluid stream inside the cementing head, and may be darts, balls, bombs, canisters and combinations thereof. The launching chambers are in fluid communication with an external power source for launching the activation device into the principal process-fluid stream.

Abstract: An apparatus for remotely launching cementing plugs is configured such that the length of a dart is not necessarily the same as the corresponding plug to be launched. A hydraulic-liquid reservoir and a piston are incorporated into a plug-launching system. The size of the reservoir may be adjusted such that the axial displacement of the piston after the dart lands is sufficient to cause the expulsion of a plug from the apparatus.

Abstract: A fluid end for use in a high-pressure, reciprocating, fluid pump assembly is provided having a bore therethrough in which a plunger reciprocates. The fluid end is provided with an insert to improve the fluid end washout life. In one embodiment, the insert is constructed of a ceramic material. In another embodiment, the insert includes an abrasive resistant coating or lining.

Abstract: A multiple activation-device launching system for a cementing head comprises a launcher body and at least one launching chamber that are sized to receive one or more activation devices therein. The activation devices are launched into the principal process-fluid stream inside the cementing head, and may be darts, balls, bombs, canisters and combinations thereof. The launching chambers are in fluid communication with an external power source for launching the activation device into the principal process-fluid stream.

Abstract: An apparatus for remotely launching cementing plugs is configured such that the length of a dart need not necessarily be the same as the corresponding plug to be launched. A hydraulic-liquid reservoir and a piston are incorporated into a plug-launching system. The size of the reservoir may be adjusted such that the axial displacement of the piston after the dart lands is sufficient to cause the expulsion of a plug from the apparatus.

Abstract: The invention relates to a multiple activation-device launching system for a cementing head, comprising a launcher body comprising at least one launching chamber and a device chamber, the launching chamber sized to receive one or more activation devices therein, the launching chamber in fluid communication with a power source for launching the activation device into the device chamber. Then the invention relates to various methods involving such system.

Abstract: A multiple activation-device launching system for a cementing head comprises a launcher body and at least one launching chamber that are sized to receive one or more activation devices therein. The activation devices are launched into the principal process-fluid stream inside the cementing head, and may be darts, balls, bombs, canisters and combinations thereof. The launching chambers are in fluid communication with an external power source for launching the activation device into the principal process-fluid stream.

Abstract: The invention relates to a multiple activation-device launching system for a cementing head, comprising a launcher body comprising at least one launching chamber and a device chamber, the launching chamber sized to receive one or more activation devices therein, the launching chamber in fluid communication with a power source for launching the activation device into the device chamber. Then the invention relates to various methods involving such system.

Abstract: An apparatus for remotely launching cementing plugs is configured such that the length of a dart is not necessarily the same as the corresponding plug to be launched. Such a design presents operational and ergonomic advantages, particularly in an offshore environment. Methods for launching cementing plugs and cementing a subterranean well are also presented.

Abstract: The invention relates to a multiple activation-device launching system for a cementing head, comprising a launcher body comprising at least one launching chamber and a device chamber, the launching chamber sized to receive one or more activation devices therein, the launching chamber in fluid communication with a power source for launching the activation device into the device chamber. Then the invention relates to various methods involving such system.