Abstract: The present disclosure provides a method of DDCE-MRF. The method can include: a) introducing two or more contrast agents to a region of interest (ROI) of a subject, the two or more contrast agents having different relaxivities; b) measuring a T1 relaxation time and a T2 relaxation time for locations within the ROI using magnetic resonance fingerprinting (MRF); c) determining, using equations that relate the different relaxivities, the T1 relaxation time, the T2 relaxation time, and concentrations of the two or more contrast agents, the concentrations of the two or more contrast agents for each of the locations within the ROI; and d) producing an image depicting the ROI based, at least in part, on the concentrations of the two or more contrast agents.

Abstract: The present disclosure provides a method of DDCE-MRF. The method can include: a) introducing two or more contrast agents to a region of interest (ROI) of a subject, the two or more contrast agents having different relaxivities; b) measuring a T1 relaxation time and a T2 relaxation time for locations within the ROI using magnetic resonance fingerprinting (MRF); c) determining, using equations that relate the different relaxivities, the T1 relaxation time, the T2 relaxation time, and concentrations of the two or more contrast agents, the concentrations of the two or more contrast agents for each of the locations within the ROI; and d) producing an image depicting the ROI based, at least in part, on the concentrations of the two or more contrast agents.

Abstract: A system and method is provided for operating a high-field magnetic resonance (MR) system includes performing a series of data acquisition modules without respiratory gating. Each data acquisition module is formed of a steady-state free precession pulse sequence. Performing the series of data acquisition modules includes varying at least one of an amplitude of an excitation pulse or a repetition time of the steady-state free precession pulse sequence between adjacent data acquisition modules in the series of data acquisition modules to acquire a series of MR data with random or pseudo-random imaging acquisition parameters. The series of MR data is compared to a dictionary of signal evolution profiles to determine a match between the series of MR data with at least one signal evolution profile in the dictionary indicating at least one quantitative parameter in the subject.

Abstract: A system and method for evaluating subjects using MRI and a contrast agent that overcomes the low sensitivity nature of previous detection methods is provided by using a 3D golden-angle-based radial sampling approach. In one configuration, direct detection of metabolic H217O generated from mitochondrial respiration may be imaged. Radial encoding allows for the use of ultra-short echo-time to compensate for signal loss due to the short T2 relaxation time of 17O and other contrast agents. In addition, the golden-ratio-based sampling scheme has the flexibility of enabling various undersampling schemes and retrospective selection of temporal resolution for dynamic imaging. A 3D radial sampling scheme may also give rise to additional SNR gain by further shortening the echo-time.

Abstract: A system and method is provided for operating a high-field magnetic resonance (MR) system includes performing a series of data acquisition modules without respiratory gating. Each data acquisition module is formed of a steady-state free precession pulse sequence. Performing the series of data acquisition modules includes varying at least one of an amplitude of an excitation pulse or a repetition time of the steady-state free precession pulse sequence between adjacent data acquisition modules in the series of data acquisition modules to acquire a series of MR data with random or pseudo-random imaging acquisition parameters. The series of MR data is compared to a dictionary of signal evolution profiles to determine a match between the series of MR data with at least one signal evolution profile in the dictionary indicating at least one quantitative parameter in the subject.

Abstract: Example apparatus and methods concern determining whether a target material appears in a region experiencing nuclear magnetic resonance (NMR). One method acquires a baseline value for a magnetic resonance parameter (MRP) while the region is not exposed to a molecular imaging agent that affects the MRP and acquires a series of quantitative values for the MRP while the sample is influenced by a molecular imaging agent. Quantitative values may be acquired during a clinically relevant time period (e.g., 60 minutes) during which the change in the MRP (e.g., T1) caused by the molecular imaging agent is at least 90% of the peak change caused by the molecular imaging agent. The molecular imaging agent may be SBK2 and may produce a desired change in T1 for at least thirty minutes in glioblastoma.

Abstract: A multi-modality, multi-resource, information integration environment system is disclosed that comprises: (a) at least one computer readable medium capable of securely storing and archiving system data; (b) at least one computer system, or program thereon, designed to permit and facilitate web-based access of the at least one computer readable medium containing the secured and archived system data; (c) at least one computer system, or program thereon, designed to permit and facilitate resource scheduling or management; (d) at least one computer system, or program thereon, designed to monitor the overall resource usage of a core facility; and (e) at least one computer system, or program thereon, designed to track regulatory and operational qualifications.

Abstract: The invention relates to micelles that are elaborated with functionality useful for imaging and/or selectively targeting tissue, e.g., in the delivery of hydrophobic agents.

Abstract: A multi-modality, multi-resource, information integration environment system is disclosed that comprises: (a) at least one computer readable medium capable of securely storing and archiving system data; (b) at least one computer system, or program thereon, designed to permit and facilitate web-based access of the at least one computer readable medium containing the secured and archived system data; (c) at least one computer system, or program thereon, designed to permit and facilitate resource scheduling or management; (d) at least one computer system, or program thereon, designed to monitor the overall resource usage of a core facility; and (e) at least one computer system, or program thereon, designed to track regulatory and operational qualifications.

Abstract: A probe suitable for attachment to, or incorporation in, a medical interventional device, such as a catheter, and which may be employed for tracking, imaging, or both, includes a first material having an MR resonance frequency distinct from a resonance frequency of a second material adjacent to the first material. The probe may include one or more coils, or it may be wireless, that is, it may have no coils. Some probe configurations are directed at tracking or imaging of vascular vessels or tissue, and configurations allow both tracking and imaging.

Abstract: The invention relates to micelles that are elaborated with functionality useful for imaging and/or selectively targeting tissue, e.g., in the delivery of hydrophobic agents.

Abstract: A probe suitable for attachment to, or incorporation in, a medical interventional device, such as a catheter, and which may be employed for tracking, imaging, or both, includes a first material having an MR resonance frequency distinct from a resonance frequency of a second material adjacent to the first material. The probe may include one or more coils, or it may be wireless, that is, it may have no coils. Some probe configurations are directed at tracking or imaging of vascular vessels or tissue, and configurations allow both tracking and imaging.

Abstract: A method of automatically adjusting at least one MR image parameter for an interventional procedure includes adaptively tracking an MR micro-coil catheter and automatically updating an imaging scan plane's position and orientation, as well as other features including, but not limited to, field-of-view, resolution, temporal resolution, slice thickness, tip angle, and TE. The disclosed system provides a more natural interface for a physician operating the MR scanner during an interventional procedure. The scanner can react to changes in the clinical environment and automatically adjust a number of image parameters. For example, during catheter insertion, images are acquired at lower resolutions, and possibly larger fields of view, to help facilitate faster updates and tracking. Once the catheter reaches a target area in the tissue and its motion slows, an MR image of higher resolution, and possibly lower field of view, is acquired.

Abstract: MP-SSFP sequences, including intervolume sequences and CHESS sequences, that facilitate improving MR imaging are provided. Slice selective pulses in an MP-SSFP sequence are altered so that a smaller set of spins refocus at echo time during a missed pulse, reducing artifacts in an image reconstructed from a signal acquired from the refocused spins. In one example, a slice selective pulse is replaced with a chemical shift selective pulse so that the intersecting sets of spins are chemically related. In another example, an RF pulse is altered so that it acts as an intervolume selecting pulse.