Abstract: The present disclosure provides methods and kits for identifying and treating individuals at risk of or suffering from amyloid transthyretin cardiomyopathy. In general, detection or measurement of one or more biomarkers, such as TnI, PKM1, PKM2, NT-proBNP, RBP4, DCN, TIMP2, SMOC-2, NfL, or combinations thereof, assists in the identification of amyloid transthyretin cardiomyopathy. The present disclosure also provides methods for selecting patients for treatment of amyloid transthyretin cardiomyopathy, such as with transthyretin stabilizing agents.

Abstract: An aircraft landing gear assembly comprising a first member coupled to a second member in parallel by a bolt. First and second mechanical fixings are mounted on the bolt and arranged to apply a clamping force to the members. The first member is arranged in use to be loaded and the second member is anchored to react the load. The assembly includes one or more spacers, each spacer defining one or more land regions and one or more voids. Each spacer is provided between the inner axial face of one of the fixings and the flat outer face of the respective member such that the land regions separate the fixing from the member and the voids are positioned such that angular movement of the fixing due to deflection of the bolt causes the radially outermost point on the fixing sidewall to move into one of the voids.

Abstract: A system for lowering an air return filter comprising: a reel; a cable system attached to the reel; and an air return filter engaged at the end of the cable system, where the reel and the cable system enable a vertical adjustment of the air return filter. Preferably, the air return filter may seal a return air duct, where the air return filter is with a frame opening of a ceiling. Further, the air return filter may include a removable filter and is connected to a HVAC system.

Abstract: A method of controlling an isolated high voltage circuit of a vehicle comprising the high voltage circuit and a low voltage circuit wherein the high voltage circuit is isolated from the low voltage circuit, the method comprising: detecting a change in an isolation resistance of the high voltage circuit from the low voltage circuit; determining a speed of the vehicle; operating the high voltage circuit in dependence on the change in the isolation resistance and the speed of the vehicle.

Abstract: A pin joint assembly for an aircraft landing gear having an elongate joint pin; at least one first lug through which the joint pin passes; and at least one second lug through which the joint pin passes. The joint pin assembly includes first and second retaining elements located at opposite ends of the joint pin and arranged to maintain the location of the joint pin relative to the first and second lugs. At least portion of the pin joint assembly is elastically deformable.

Abstract: A tool for detecting deformation of a nominally straight element includes a first body element having first straight edge, means for biasing the first straight edge against the straight element, and a light source arranged to illuminate any space present between the straight element and the first straight edge of the first body element.

Abstract: An aircraft brake assembly comprising a support leg, a main wheel rotatably mounted on the support leg, a brake comprising a first sub-assembly fixed to the main wheel and a second sub-assembly moveably mounted on the support leg and a ground reaction wheel coupled to the second sub-assembly, wherein on application of the brake, the first sub-assembly engages with the second sub-assembly to exert a braking force on the second sub-assembly; and wherein the ground reaction wheel is arranged to transfer the braking force from the second sub-assembly to the ground.

Abstract: A system for lowering an air vent comprising: a reel; a cable system attached to the reel; and an air vent engaged at the end of the cable system, where the reel and the cable system enable a vertical adjustment of the air vent. Preferably, the air vent may seal a return air duct, where the air vent is with a frame opening of a ceiling. Further, the air vent may include a removable filter and is connected to a HVAC system.

Abstract: A method of controlling an isolated high voltage circuit of a vehicle comprising the high voltage circuit and a low voltage circuit wherein the high voltage circuit is isolated from the low voltage circuit, the method comprising: detecting a change in an isolation resistance of the high voltage circuit from the low voltage circuit; determining a speed of the vehicle; operating the high voltage circuit in dependence on the change in the isolation resistance and the speed of the vehicle.

Abstract: A method of monitoring a mine operation is disclosed. The method comprises collecting map data associated with a mine operation, the map data being indicative of at least one map representation associated with the mine operation, collecting mine equipment location data indicative of the location of at least one item of mine equipment relative to the mine operation, and facilitating selection and display of a map representation associated with a mine operation. When a map representation associated with a mine operation is displayed, a representation of at least one item of mine equipment on the map representation at a representative location relative to the mine operation.

Abstract: A tool for detecting deformation of a nominally straight element includes a first body element having first straight edge, means for biasing the first straight edge against the straight element, and a light source arranged to illuminate any space present between the straight element and the first straight edge of the first body element.

Abstract: A pin joint assembly for an aircraft landing gear having an elongate joint pin; at least one first lug through which the joint pin passes; and at least one second lug through which the joint pin passes. The joint pin assembly includes first and second retaining elements located at opposite ends of the joint pin and arranged to maintain the location of the joint pin relative to the first and second lugs. At least portion of the pin joint assembly is elastically deformable.

Abstract: An improved process for producing flexographic printing plates using a digital workflow is described. After creating an in-situ digital mask over the photopolymerizable layer, the photopolymerizable layer is exposed to actinic radiation through the mask layer in a reduced oxygen environment. After subsequent development, the resulting relief printing form is composed of flat topped dots with crisp edges and steep bevel angles that can be used to print directly on corrugated materials.

Abstract: An aircraft brake assembly comprising a support leg, a main wheel rotatably mounted on the support leg, a brake comprising a first sub-assembly fixed to the main wheel and a second sub-assembly moveably mounted on the support leg and a ground reaction wheel coupled to the second sub-assembly, wherein on application of the brake, the first sub-assembly engages with the second sub-assembly to exert a braking force on the second sub-assembly; and wherein the ground reaction wheel is arranged to transfer the braking force from the second sub-assembly to the ground.

Abstract: Electrical power adapters comprising retractable prongs and/or retractable electrical outputs are disclosed. In one example, an electrical travel adapter includes a power unit having a retractable electrical output and a plug unit coupled to the power unit, the plug unit having a plurality of retractable prongs.