Abstract: This invention related to compounds that are inhibitors of the CDK12 kinase. The compounds are useful in the treatment of disorders mediated by the CDK12 kinase including myotonic dystrophy type 1 (DM1) and other disorders caused by the generation of RNA repeat expansion transcripts. In particular, the invention relates to compounds of the formula (I), or a pharmaceutically acceptable salts or N-oxides thereof, wherein R1a, R2, R3, R4a, R4b and R4c are as defined herein.

Abstract: This invention related to compounds that are inhibitors of the CDK12 kinase. The compounds are useful in the treatment of disorders mediated by the CDK12 kinase including myotonic dystrophy type 1 (DM1) and other disorders caused by the generation of RNA repeat expansion transcripts. In particular, the invention relates to compounds of the formula (I), or a pharmaceutically acceptable salts or N-oxides thereof, wherein R1a, R2, R3, R4a, R4b and R4c are as defined herein.

Abstract: A CAC/PIV certificate associated with a HSPD-12 identity is used to generate a derived credential for storage on a device, such as a mobile device, that lacks a CAC/PIV card reader. The derived credential (which is distinct from the original CAC/PIV certificate) may then be used to grant the device access to secure resources that may otherwise require a CAC/PIV certificate. Embodiments of the present disclosure also relate to systems and methods for authenticating or validating a derived credential stored on a mobile device.

Abstract: A CAC/PIV certificate associated with a HSPD-12 identity is used to generate a derived credential for storage on a device, such as a mobile device, that lacks a CAC/PIV card reader. The derived credential (which is distinct from the original CAC/PIV certificate) may then be used to grant the device access to secure resources that may otherwise require a CAC/PIV certificate. Embodiments of the present disclosure also relate to systems and methods for authenticating or validating a derived credential stored on a mobile device.

Abstract: A CAC/PIV certificate associated with a HSPD-12 identity is used to generate a derived credential for storage on a device, such as a mobile device, that lacks a CAC/PIV card reader. The derived credential (which is distinct from the original CAC/PIV certificate) may then be used to grant the device access to secure resources that may otherwise require a CAC/PIV certificate. Embodiments of the present disclosure also relate to systems and methods for authenticating or validating a derived credential stored on a mobile device.

Abstract: Intelligent markers and a card distribution error reduction system are disclosed. In one embodiment, the invention includes intelligent markers which are effectively “player acknowledgement” indicators. The markers preferably include a mechanism for signaling the receiving bettor to acknowledge receipt of the marker, which acknowledgement may turn off the indicating mechanism. The method of indication could be visual, audible or otherwise which would signal a bettor to interact with the marker. The intelligent markers communicate with table sensors and a shoe to monitor the status of games, and to signal alerts when a mistake occurs.

Abstract: An apparatus for providing enhanced radar video processing may include a processing element. The processing element may be configured to receive, from a state table that is oriented in a fixed orientation, data based on a radar return, to store a texture corresponding to an image based on the received data, the texture being oriented with respect to a center of a radar sweep, to define a plurality of adjacent vertex buffers, and to map the texture to at least one of the vertex buffers in which portions of the texture are capable of being scrambled within at least one of the vertex buffers.

Abstract: An apparatus for providing enhanced radar video processing may include a processing element. The processing element may be configured to receive, from a state table that is oriented in a fixed orientation, data based on a radar return, to store a texture corresponding to an image based on the received data, the texture being oriented with respect to a center of a radar sweep, to define a plurality of adjacent vertex buffers, and to map the texture to at least one of the vertex buffers in which portions of the texture are capable of being scrambled within at least one of the vertex buffers.

Abstract: An airbag door system is provided comprising a substrate, an outer shell and a foam where all three layers possess a line of mechanical weakness with each line of mechanical weakness at least partially separating each layer into an airbag door portion and a trim member portion. The substrate line of mechanical weakness comprises at least one substrate aperture. The outer shell line of mechanical weakness comprises an outer shell reduced thickness portion defined by an outer shell sever extending partially through an outer shell thickness from an outer shell lower surface towards an outer shell upper surface. The foam line of mechanical weakness comprises a foam reduced thickness portion defined by a foam sever extending partially through a foam thickness from a foam lower surface towards a foam upper surface. The outer shell line of mechanical weakness is displaced relative to a foam line of mechanical weakness.

Abstract: An airbag door system is provided comprising a substrate, an outer shell and a foam where all three layers possess a line of mechanical weakness with each line of mechanical weakness at least partially separating each layer into an airbag door portion and a trim member portion. The substrate line of mechanical weakness comprises at least one substrate aperture. The outer shell line of mechanical weakness comprises an outer shell reduced thickness portion defined by an outer shell sever extending partially through an outer shell thickness from an outer shell lower surface towards an outer shell upper surface. The foam line of mechanical weakness comprises a foam reduced thickness portion defined by a foam sever extending partially through a foam thickness from a foam lower surface towards a foam upper surface. The outer shell line of mechanical weakness is displaced relative to a foam line of mechanical weakness.

Abstract: An airbag door system is provided comprising a substrate, an outer shell and a foam where all three layers possess a line of mechanical weakness with each line of mechanical weakness at least partially separating each layer into an airbag door portion and a trim member portion. The substrate line of mechanical weakness comprises at least one substrate aperture. The outer shell line of mechanical weakness comprises an outer shell reduced thickness portion defined by an outer shell sever extending partially through an outer shell thickness from an outer shell lower surface towards an outer shell upper surface. The foam line of mechanical weakness comprises a foam reduced thickness portion defined by a foam sever extending partially through a foam thickness from a foam lower surface towards a foam upper surface. The outer shell line of mechanical weakness is displaced relative to a foam line of mechanical weakness.

Abstract: An airbag door system is provided comprising a substrate, an outer shell and a foam where all three layers possess a line of mechanical weakness with each line of mechanical weakness at least partially separating each layer into an airbag door portion and a trim member portion. The substrate line of mechanical weakness comprises at least one substrate aperture. The outer shell line of mechanical weakness comprises an outer shell reduced thickness portion defined by an outer shell sever extending partially through an outer shell thickness from an outer shell lower surface towards an outer shell upper surface. The foam line of mechanical weakness comprises a foam reduced thickness portion defined by a foam sever extending partially through a foam thickness from a foam lower surface towards a foam upper surface. The outer shell line of mechanical weakness is displaced relative to a foam line of mechanical weakness.

Abstract: An airbag door system is provided comprising a substrate, an outer shell and a foam where all three layers possess a line of mechanical weakness with each line of mechanical weakness at least partially separating each layer into an airbag door portion and a trim member portion. The substrate line of mechanical weakness comprises at least one substrate aperture. The outer shell line of mechanical weakness comprises an outer shell reduced thickness portion defined by an outer shell sever extending partially through an outer shell thickness from an outer shell lower surface towards an outer shell upper surface. The foam line of mechanical weakness comprises a foam reduced thickness portion defined by a foam sever extending partially through a foam thickness from a foam lower surface towards a foam upper surface. The outer shell line of mechanical weakness is displaced relative to a foam line of mechanical weakness.