Abstract: A method of delivering a therapeutic substance for treatment to a region of the body through vascular isolation and manipulation of fluid flux into and from the region of the body including the steps of: restricting vascular inflow to the region of the body; washing out oncotically active plasma proteins from the region of the body by increasing the outward oncotic pressure gradient from the region of the body; inducing ischemia in the region of the body; controlling the pressure and fluid flow of the main blood vessels to and from the region of the body; providing the therapeutic substance to the region of the body when the fluid flow to the region of the body is controlled.

Abstract: The present disclosure concerns a vascular access device (1) comprising a vascular access tube (2), such as a cannula, having a distal end region (3) terminating in a tip (4) for insertion into a blood vessel (V) of a patient and at least one lumen (5) for infusing a medicament and/or for introducing one or more catheters there-through into the blood vessel (V). The device (1) further comprises a fixation mechanism (10) that is operable to secure or fix the distal end region (3) of the vascular access tube (2) with respect to the patient to inhibit or prevent withdrawal of the tip (4) from the blood vessel (V) and/or to inhibit or prevent overinsertion of the tip (4) into the blood vessel (V).

Abstract: A method of delivering a therapeutic substance for treatment to a region of the body through vascular isolation and manipulation of fluid flux into and from the region of the body including the steps of: restricting vascular inflow to the region of the body; washing out oncotically active plasma proteins from the region of the body by increasing the outward oncotic pressure gradient from the region of the body; inducing ischemia in the region of the body; controlling the pressure and fluid flow of the main blood vessels to and from the region of the body; providing the therapeutic substance to the region of the body when the fluid flow to the region of the body is controlled.

Abstract: Multiple access hard disk. Multiple read-write heads are implemented within a single information storage device. The information storage device can be any of a variety of information storage devices including a hard disk drive (HDD), a CD-ROM (Compact Disc Read Only Memory) drive, a DVD (Digital Video Disc or Digital Versatile Disc) drive, a read-write capable CD (Compact Disc) drive, or a read-write capable DVD drive. Each read-write head may couple to a separate user (or separate device, and/or separate network). Alternatively, more than one of the read-write heads may couple to a single user (or single device, and/or single network). The manner in which each of these read-write heads may be implemented within the information storage device can be varied. If desired, the read-write heads can be arranged in a spoke-like arrangement around a circumference of a circular, spin-capable storage media.