Abstract: Particles are provided which are suitable for delivery from a particle-mediated delivery device. The particles are obtained by precipitating a nucleic acid on inert metal carrier particles in the presence of a nucleic acid condensing agent and a metal ion chelating agent. Also described are processes for preparing the particles, and therapeutic methods using the particles including methods of nucleic acid immunisation and gene therapy.

Abstract: A system and method is disclosed for creating, ordering and printing custom-created graphical images on a variety of printable media via a data network, such as the Internet or Intranet. The system includes a database storing references to available graphical image options (background, text, icons and overall layout), pricing information and customer information and a distributed printing system including one or more printers located at one or more printing facilities for printing printed products. The system further includes a distributed order processing system having one or more order processors associated with one or more printers at a printing facility, in which each of the order processors is capable of requesting an order that includes the references to the selected graphical image options from the database. Each order processor further includes a rendering agent that interprets the order to produce a final print image for printing on one of the associated printers at the printing facility.