Abstract: The present invention relates to therapies and therapeutic agents for use in the treatment of cardiomyopathies. In particular, the invention is concerned with, but not limited to therapies and therapeutic agents for use in the treatment of hypertrophic cardiomyopathy. Such therapeutic agents comprise hypomethylating agents.

Abstract: A vertical-axis wind turbine generator includes two or more rotor assemblies, each rotor assembly having two or more wind turbine blades mounted for rotation, preferably those having a Savonius configuration. A cowling includes a nose portion forming a bifurcating wind diverter, in which the bifurcated airflow is directed in order to cause counter directional flow of the wind turbine blades. According to at least one version, the cowling further includes a cover portion that defines a venturi chamber above the rotating blades to draw air into the top of the turbine above the rotating blades and create a vacuum, thereby reducing resistance. The cowling can be part of an existing wind turbine or alternatively replace an original cowling as a retrofit.

Abstract: An electronic begin of regulation (EBOR) control system and method is disclosed for a hydraulic motor of a machine having an engine for producing power and a track system for moving. The EBOR system includes a flow source, variable displacement motor, pressure sensor and control unit. The operator sets a pressure setpoint. The flow source generates flow in a loop with the motor. The pressure sensor senses loop working pressure. The control unit adjusts motor displacement based on comparisons between the pressure setpoint and sensed loop working pressure. The flow source can be bidirectional, and different pressure sensors can be used depending on the direction. The pressure setpoint can be varied during operation, and the control unit can adjust the displacement of the motor based on comparisons between the latest pressure setpoint and the loop working pressure sensed by the appropriate pressure sensor.

Abstract: An electronic begin of regulation (EBOR) control system and method is disclosed for a hydraulic motor of a machine having an engine for producing power and a track system for moving. The EBOR system includes a flow source, variable displacement motor, pressure sensor and control unit. The operator sets a pressure setpoint. The flow source generates flow in a loop with the motor. The pressure sensor senses loop working pressure. The control unit adjusts motor displacement based on comparisons between the pressure setpoint and sensed loop working pressure. The flow source can be bidirectional, and different pressure sensors can be used depending on the direction. The pressure setpoint can be varied during operation, and the control unit can adjust the displacement of the motor based on comparisons between the latest pressure setpoint and the loop working pressure sensed by the appropriate pressure sensor.

Abstract: A method and apparatus are provided for coupling a pump head (1) and a motor housing (4) of a pump together so that a rotational positioning ring (2) of the pump head (1) frictionally engages a snap ring (5) of the motor housing (4) so as to allow for 360° rotation of the pump head (1) in relation to the motor housing (4), where the orientation of the pump head (1) and the motor housing (4) are adjustable in relation to one another so as to allow an end user to set the orientation of the pump in any configuration. The positioning ring (2) has a plurality of members separated by slots for radially flexing when the rotational positioning ring (2) is axially coupled over the snap ring (5) of the motor housing (4). Each of the plurality of members has a rim so as to form a raised edge for frictionally engaging a corresponding raised edge of the snap ring (5) of the motor housing (4).

Abstract: A laminar flow waterfall in the form of a single or multiple streams of water, each exiting from a nozzle in the top edge of a spa. The laminar water stream is created by a venturi nozzle located in a plenum chamber. The inlet side of the nozzle has a cover with a plurality of small holes forcing the water flow to enter the nozzle as laminar flow. A flow divider inside the venturi nozzle, from the inlet to the restriction of the nozzle, maintains the flow laminar through the nozzle. Light is injected into the flow divider at the inlet and is carried by the flow divider to be injected into the water flow at the restriction of the nozzle.

Abstract: A dry suction fitting assembly is provided for drawing water from a spa, whirlpool bathtub or other suitable water tub to a pump, featuring a suction body for arranging in relation to a wall of the spa, whirlpool bathtub or other suitable water tub. The suction body is arranged in relation to a wall of the spa, whirlpool bathtub or other suitable water tub, has a suction inlet for coupling to the pump, and has an internal surface with an equilibrium tube arranged therein with three openings, a first opening that acts as a water flow inlet, a second opening that is open to the atmosphere via a connection hose or other suitable connection device and that is filled with water during normal operation, and a third opening that is a safety orifice coupled to the suction inlet. During normal operation water flows from the first opening, through the equilibrium tube, and out the third opening.

Abstract: A connector includes sheet metal contacts (40, 42) with termination ends (60, 62) for terminating to wires and with mating ends (70, 72) for mating to other contact devices such as circuit board pads. Each terminating end includes a wide groove part (90) with a groove bottom (94) that receives the wire insulation and with a pair of wide groove part wings (96, 98) that are crimped around the insulation. Each termination end also includes a narrow groove part (100) for receiving a bared conductor of the wire, the narrow groove part having a bottom (104) that is offset from the wide groove part bottom (94), and the narrow groove part having a pair of narrow groove part wings (106, 108) that are crimped around the wire conductor.

Abstract: A two-stage fluid pressure control valve has five components. An inlet socket with separate fluid flow orifices sealably engages an outlet socket which also has separate fluid flow orifices. A pressure check piston having a fluid flow orifice along its longitudinal central axis slidably engages the inlet socket and the outlet socket. A spring located along the central axis of the outlet socket biases the pressure check piston in an open position, allowing fluid to flow through all orifices. Fluid flow through the control valve may impact the pressure check piston to overcome the spring force, moving the pressure check piston to a closed position, whereby fluid flows only through the orifice in the pressure check piston.

Abstract: A laminar flow waterfall in the form of a single or multiple streams of water, each exiting from a nozzle in the top edge of a spa. The laminar water stream is created by a venturi nozzle located in a plenum chamber. The inlet side of the nozzle has a cover with a plurality of small holes forcing the water flow to enter the nozzle as laminar flow. A flow divider inside the venturi nozzle, from the inlet to the restriction of the nozzle, maintains the flow laminar through the nozzle. Light is injected into the flow divider at the inlet and is carried by the flow divider to be injected into the water flow at the restriction of the nozzle.